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Unstable dynamics characterizes the evolution of most solid tumors. Because of an increased failure of maintaining genome integrity, a cumulative increase in the levels of gene mutation and loss is observed. Previous work suggests that…

Biological Physics · Physics 2015-06-18 Daniel R. Amor , Ricard V. Solé

We study a Cahn--Hilliard two-phase model describing the flow of two viscoelastoplastic fluids, which arises in geodynamics. A phase-field variable indicates the proportional distribution of the two fluids in the mixture. The motion of the…

Analysis of PDEs · Mathematics 2025-10-01 Fan Cheng , Robert Lasarzik , Marita Thomas

An asymptotic limit of a class of Cahn-Hilliard systems is investigated to obtain a general nonlinear diffusion equation. The target diffusion equation may reproduce a number of well-known model equations: Stefan problem, porous media…

Analysis of PDEs · Mathematics 2015-12-01 Pierluigi Colli , Takeshi Fukao

In this paper, we propose a tumor growth model to incorporate and investigate the spatial effects of autophagy. The cells are classified into two phases: normal cells and autophagic cells, whose dynamics are also coupled with the nutrients.…

Analysis of PDEs · Mathematics 2021-08-31 Xu'an Dou , Jian-Guo Liu , Zhennan Zhou

We present a phase-space analysis of a mathematical model of tumor growth with an immune responses. We consider mathematical analysis of the model equations with multipoint initial condition regarding to dissipativity, boundedness of…

Dynamical Systems · Mathematics 2019-02-28 Veli Shakhmurov , Rishad Shahmurov

We investigate the dynamics of a nonlinear system modeling tumor growth with drug application. The tumor is viewed as a mixture consisting of proliferating, quiescent and dead cells as well as a nutrient in the presence of a drug. The…

Analysis of PDEs · Mathematics 2017-05-23 Donatella Donatelli , Konstantina Trivisa

Tumor growth has long been a target of investigation within the context of mathematical and computer modelling. The objective of this study is to propose and analyze a two-dimensional probabilistic cellular automata model to describe…

Tissues and Organs · Quantitative Biology 2009-11-13 E. A. Reis , L. B. L. Santos , S. T. R. Pinho

We introduce a multi-species diffuse interface model for tumor growth, characterized by its incorporation of essential features related to chemotaxis, angiogenesis and proliferation mechanisms. We establish the weak well-posedness of the…

Analysis of PDEs · Mathematics 2023-11-23 Abramo Agosti , Andrea Signori

We derive, through the deterministic homogenization theory in thin domains, a new model consisting of Hele-Shaw equation with memory coupled with the convective Cahn-Hilliard equation. The obtained system, which models in particular tumor…

Analysis of PDEs · Mathematics 2024-04-04 Giuseppe Cardone , Willi Jäger , Jean Louis Woukeng

In this paper we study the growth of a tumor colony of multilayer type and focus on how the tumor grows from a near flat (when compared to the length of the tumor as, for instance, in the case of a bone tumor in a femur) initial colony. In…

Analysis of PDEs · Mathematics 2026-01-15 Rafael Granero-Belinchón , Martina Magliocca

In this article we consider the numerical modeling and simulation via the phase field approach of two-phase flows of different densities and viscosities in superposed fluid and porous layers. The model consists of the…

Numerical Analysis · Mathematics 2021-12-09 Yali Gao , Daozhi Han , Xiaoming He , Ulrich Rüde

The phenomenology from the time of the quench to the asymptotic behavior in the phase-ordering kinetics of a system with conserved order parameter is investigated in the Bray-Humayun model and in the Cahn-Hilliard-Cook model. From the…

Statistical Mechanics · Physics 2009-10-31 Claudio Castellano , Marco Zannetti

We are concerned with a phase field system consisting of two partial differential equations in terms of the variables thermal displacement, that is basically the time integration of temperature, and phase parameter. The system is a…

Analysis of PDEs · Mathematics 2012-05-29 Giacomo Canevari , Pierluigi Colli

We consider coarsening dynamics associated with a Burgers--Cahn--Hilliard system modeling a two-phase flow in one space dimension. Our emphasis is on the effect that coupling between the phase and fluid dynamics has on coarsening rates, and…

Analysis of PDEs · Mathematics 2024-05-21 Peter Howard , Adam Larios , Quyuan Lin

We consider a one--spatial dimensional tumour growth model [2, 3, 4] that consists of three dependent variables of space and time: volume fraction of tumour cells, velocity of tumour cells, and nutrient concentration. The model variables…

Numerical Analysis · Mathematics 2020-07-01 Jerome Droniou , Neela Nataraj , Gopikrishnan Chirappurathu Remesan

In this paper, we introduce a model describing the dynamic of vesicle membranes within an incompressible viscous fluid in $3D$ domains. The system consists of the Navier-Stokes equations, with an extra stress tensor depending on the…

Analysis of PDEs · Mathematics 2017-10-10 Blanca Climent-Ezquerra , Francisco Guillén-González

In this paper, we consider a non-linear fourth-order evolution equation of Cahn-Hilliard-type on evolving surfaces with prescribed velocity, where the non-linear terms are only assumed to have locally Lipschitz derivatives. High-order…

Numerical Analysis · Mathematics 2022-03-07 Cedric Aaron Beschle , Balázs Kovács

In this paper, we investigate a class of tumor growth models governed by porous medium-type equations with uncertainties arisen from the growth function, initial condition, tumor support radius or other parameters in the model. We develop a…

Numerical Analysis · Mathematics 2025-06-24 Ning Jiang , Liu Liu , Huimin Yu

Phase field models are widely used to describe multiphase systems. Here a smooth indicator function, called phase field, is used to describe the spatial distribution of the phases under investigation. Material properties like density or…

Numerical Analysis · Mathematics 2015-11-10 Christian Kahle

We investigate a new phase field model for representing non-oriented interfaces, approximating their area and simulating their area-minimizing flow. Our contribution is related to the approach proposed in arXiv:2105.09627 that involves ad…

Optimization and Control · Mathematics 2025-07-03 Elie Bretin , Antonin Chambolle , Simon Masnou