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In this paper, a two-dimensional model for the growth of multi-layer tumors is presented. The model consists of a free boundary problem for the tumor cell membrane and the tumor is supposed to grow or shrink due to cell proliferation or…

Analysis of PDEs · Mathematics 2013-06-11 Martin Kohlmann

The global-in-time existence of weak solutions to a degenerate Cahn-Hilliard cross-diffusion system with singular potential in a bounded domain with no-flux boundary conditions is proved. The model consists of two coupled parabolic…

Analysis of PDEs · Mathematics 2024-01-11 Ansgar Jüngel , Yue Li

We study some properties of a multi-species degenerate Ginzburg-Landau energy and its relation to a cross-diffusion Cahn-Hilliard system. The model is motivated by multicomponent mixtures where crossdiffusion effects between the different…

Analysis of PDEs · Mathematics 2024-08-08 Jean Cauvin-Vila , Virginie Ehrlacher , Greta Marino , Jan-Frederik Pietschmann

We consider a fully practical finite element approximation of a diffuse interface model for tumour growth that takes the form of a degenerate parabolic system. In addition to showing stability bounds for the approximation, we prove…

Numerical Analysis · Mathematics 2022-02-07 Joe Eyles , Robert Nürnberg , Vanessa Styles

In this work, we analytically investigate a degenerating PDE system for phase separation and complete damage processes considered on a nonsmooth time-dependent domain with mixed boundary conditions. The evolution of the system is described…

Analysis of PDEs · Mathematics 2016-09-16 Christian Heinemann , Christiane Kraus

The Cahn-Hilliard model with reaction terms can lead to situations in which no coarsening is taking place and, in contrast, growth and division of droplets occur which all do not grow larger than a certain size. This phenomenon has been…

Analysis of PDEs · Mathematics 2025-11-07 Harald Garcke , Kei Fong Lam , Robert Nürnberg , Andrea Signori

This paper is concerned with a nonlinear free boundary problem modeling the growth of spherically symmetric tumors with angiogenesis, set with a Robin boundary condition. In which, both nonnecrotic tumors and necrotic tumors are taken into…

Analysis of PDEs · Mathematics 2020-08-21 Huijuan Song , Wentao Hu , Zejia Wang

We introduce unconditionally stable finite element approximations for anisotropic Allen--Cahn and Cahn--Hilliard equations. These equations frequently feature in phase field models that appear in materials science. On introducing the novel…

Numerical Analysis · Mathematics 2015-06-02 John W. Barrett , Harald Garcke , Robert Nürnberg

We consider a diffuse interface model for tumor growth recently proposed in [Y. Chen, S.M. Wise, V.B. Shenoy, J.S. Lowengrub, A stable scheme for a nonlinear, multiphase tumor growth model with an elastic membrane, Int. J. Numer. Methods…

Analysis of PDEs · Mathematics 2015-07-29 Mimi Dai , Eduard Feireisl , Elisabetta Rocca , Giulio Schimperna , Maria Schonbek

We analyze a fully discrete finite element numerical scheme for the Cahn-Hilliard-Stokes-Darcy system that models two-phase flows in coupled free flow and porous media. To avoid a well-known difficulty associated with the coupling between…

Numerical Analysis · Mathematics 2021-06-08 Wenbin Chen , Daozhi Han , Cheng Wang , Shufen Wang , Xiaoming Wang , Yichao Zhang

We consider the numerical approximations of a two-phase hydrodynamics coupled phase-field model that incorporates the variable densities, viscosities and moving contact line boundary conditions. The model is a nonlinear, coupled system that…

Numerical Analysis · Mathematics 2017-02-15 Haijun Yu , Xiaofeng Yang

A heuristic method to find asymptotic solutions to a system of non-linear wave equations near null infinity is proposed. The non-linearities in this model, dubbed good-bad-ugly, are known to mimic the ones present in the Einstein field…

General Relativity and Quantum Cosmology · Physics 2021-07-07 Miguel Duarte , Justin Feng , Edgar Gasperin , David Hilditch

An existence result is proved for a nonlinear diffusion problem of phase-field type, consisting of a parabolic system of two partial differential equations, complemented by Neumann homogeneous boundary conditions and initial conditions.…

Analysis of PDEs · Mathematics 2012-02-24 Pierluigi Colli , Gianni Gilardi , Paolo Podio-Guidugli , Jürgen Sprekels

We consider the inverse problem of identifying parameters in a variant of the diffuse interface model for tumour growth model proposed by Garcke, Lam, Sitka and Styles (Math. Models Methods Appl. Sci. 2016). The model contains three…

Optimization and Control · Mathematics 2017-07-24 Christian Kahle , Kei Fong Lam

In this paper we study the rigorous sharp interface limit of a diffuse interface model related to the dynamics of tumor growth, when a parameter $\epsilon$, representing the interface thickness between the tumorous and non tumorous cells,…

Analysis of PDEs · Mathematics 2016-12-21 E. Rocca , R. Scala

We investigate a nonstandard phase field model of Cahn-Hilliard type. The model describes two-species phase segregation and consists of a system of two highly nonlinearly coupled PDEs. It has been studied recently in the papers…

Analysis of PDEs · Mathematics 2012-01-31 Pierluigi Colli , Gianni Gilardi , Jürgen Sprekels

A distributed optimal control problem for an extended model of phase field type for tumor growth is addressed. In this model, the chemotaxis effects are also taken into account. The control is realized by two control variables that design…

Analysis of PDEs · Mathematics 2021-03-23 Pierluigi Colli , Andrea Signori , Jürgen Sprekels

In this note, we study the optimal control of a nonisothermal phase field system of Cahn-Hilliard type that constitutes an extension of the classical Caginalp model for nonisothermal phase transitions with a conserved order parameter. It…

Optimization and Control · Mathematics 2023-03-24 Pierluigi Colli , Gianni Gilardi , Andrea Signori , Jürgen Sprekels

A proof of optimal-order error estimates is given for the full discretization of the bulk--surface Cahn--Hilliard system with dynamic boundary conditions in a smooth domain. The numerical method combines a linear bulk--surface finite…

Numerical Analysis · Mathematics 2025-02-07 Nils Bullerjahn

A Cahn-Hilliard-type theory for hydrodynamic fluctuations is proposed that gives a quantitative description of the slowly evolving spatial correlations and structures in density and flow fields in the early stages of evolution of freely…

Statistical Mechanics · Physics 2009-10-31 T. P. C. van Noije , M. H. Ernst
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