Related papers: Geometry of Morphogenesis
It is proposed that space is a four-dimensional Euclidean space with universal time. Originally this space was filled with a uniform substance, pictured as a liquid, which at some time became supercooled. Our universe began as a nucleation…
In higher organisms, all cells share the same genome, but every cell expresses only a limited and specific set of genes that defines the cell type. During cell division, not only the genome, but also the cell type is inherited by the…
Motivated by Felix Klein's notion that geometry is governed by its group of symmetry transformations, Charles Ehresmann initiated the study of geometric structures on topological spaces locally modeled on a homogeneous space of a Lie group.…
We develop the spectral point of view on geometry based on the formalism of quantum physics. We start from the simple physical question of specifying our position in space and explain how the spectral geometric point of view provides a new…
Many organs of higher organisms are heavily branched structures and arise by an at first sight similar process of branching morphogenesis. Yet the regulatory components and local interactions that have been identified differ greatly in…
In this review, we discuss modularity and hierarchy in biological systems. We review examples from protein structure, genetics, and biological networks of modular partitioning of the geometry of biological space. We review theories to…
Spatial distributions of morphogens provide positional information in developing systems, but how the distributions are established and maintained remains an open problem. Transport by diffusion has been the traditional mechanism, but…
We introduce a new 2-D hexagon technique to probe the topological structure of the universe, in which we map regions of the sky with high and low galaxy densities onto a 2-D lattice of hexagon unit cells, We define filled cells as…
In the past 50 years, the formalism of L-systems has been successfully used and developed to model the growth of filamentous and branching biological forms. These simulations take place in classical 2-D or 3-D Euclidean spaces. However,…
Coordinated movements of epithelia tissue are linked with active matter processes. We here consider the influence of curvature on the spatiotemporal arrangements and the shapes of the cells. The cells are represented by a multiphase field…
How does the topological space of science emerge? Inspired by the concept of maps of science, i.e. mapping scientific topics to a scientific space, we ask which topological structure a dynamical process of authors collaborating and…
The mitosis process of an eukaryotic cell can be represented by the structure constants of an evolution algebra. Any isotopism of the latter corresponds to a mutation of genotypes of the former. This paper uses Computational Algebraic…
A curious feature of organ and organoid morphogenesis is that in certain cases, spatial oscillations in the thickness of the growing "film" are out-of-phase with the deformation of the slower-growing "substrate," while in other cases, the…
A distinguishing feature of a multicellular living system is that it operates at various scales, from the intracellular to organismal. Very little is known at present on how tissue level properties are related to cell and subcellular…
Deformations of cell sheets during morphogenesis are driven by developmental processes such as cell division and cell shape changes. In morphoelastic shell theories of development, these processes appear as variations of the intrinsic…
Adhering cells actively probe the mechanical properties of their environment and use the resulting information to position and orient themselves. We show that a large body of experimental observations can be consistently explained from one…
In this survey article, a variety of systems modeling tumor growth are discussed. In accordance with the hallmarks of cancer, the described models incorporate the primary characteristics of cancer evolution. Specifically, we focus on…
We consider spacetime to be a 4-dimensional differentiable manifold that can be split locally into time and space. No metric, no linear connection are assumed. Matter is described by classical fields/fluids. We distinguish electrically…
During development, spatio-temporal patterns ranging from checkerboard to engulfing occur with precise proportions of the respective cell fates. Key developmental regulators are intracellular transcriptional interactions and intercellular…
The ability of eukaryotic cells to squeeze through constrictions is limited by the stiffness of their large and rigid nucleus. However, migrating cells are often able to overcome this limitation and pass through constrictions much smaller…