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Identifying cancer driver genes is crucial for understanding tumor biology and developing precision therapies. However, existing computational methods often rely on single biological networks or population-level mutation patterns, limiting…

Quantitative Methods · Quantitative Biology 2026-01-06 Xueqing Xu , Yonghang Gao , Duanchen Sun , Ling-Yun Wu

The rapid development of tools for acquisition and storage of information has lead to the formation of enormous medical databases. The large quantity of data definitely surpasses the abilities of humans for efficient usage without…

Information Retrieval · Computer Science 2009-04-03 Petar Kormushev

Integration of transcriptomic and metabolomic data improves functional interpretation of disease-related metabolomic phenotypes, and facilitates discovery of putative metabolite biomarkers and gene targets. For this reason, these data are…

Studying phenotype-gene association can uncover mechanism of diseases and develop efficient treatments. In complex disease where multiple phenotypes are available and correlated, analyzing and interpreting associated genes for each…

Methodology · Statistics 2021-12-14 Yujia Li , Yusi Fang , Peng Liu , George C. Tseng

The human genome is incredibly information-rich, consisting of approximately 25,000 protein-coding genes spread out over 3.2 billion nucleotide base pairs contained within 24 unique chromosomes. The genome is important in maintaining…

Human-Computer Interaction · Computer Science 2023-08-28 Gunnar Reiske , Sungwon In , Yalong Yang

Multi-view datasets offer diverse forms of data that can enhance prediction models by providing complementary information. However, the use of multi-view data leads to an increase in high-dimensional data, which poses significant challenges…

Neural and Evolutionary Computing · Computer Science 2024-03-05 Vandad Imani , Carlos Sevilla-Salcedo , Elaheh Moradi , Vittorio Fortino , Jussi Tohka

The human genotope is the convex hull of all allele frequency vectors that can be obtained from the genotypes present in the human population. In this paper we take a few initial steps towards a description of this object, which may be…

Populations and Evolution · Quantitative Biology 2011-11-10 Peter Huggins , Lior Pachter , Bernd Sturmfels

The recent explosion of genomic data has underscored the need for interpretable and comprehensive analyses that can capture complex phylogenetic relationships within and across species. Recombination, reassortment and horizontal gene…

Quantitative Methods · Quantitative Biology 2016-09-28 Pablo G. Camara , Arnold J. Levine , Raul Rabadan

Graph invariants provide a powerful analytical tool for investigation of abstract structures of graphs. They, combined in convenient relations, carry global and general information about a graph and its various substructures such as cycle…

Combinatorics · Mathematics 2010-09-15 Zh. G. Nikoghosyan

Exploratory search starts with ill-defined goals and involves browsing, learning, and formulating new targets for search. To fluidly support such dynamic search behaviours, we focus on devising interactive visual facets (IVF), visualising…

Human-Computer Interaction · Computer Science 2021-09-14 Chen He , Luana Micallef , Barış Serim , Tung Vuong , Tuukka Ruotsalo , Giulio Jacucci

Cancer diagnosis, prognosis, and therapeutic response predictions are based on morphological information from histology slides and molecular profiles from genomic data. However, most deep learning-based objective outcome prediction and…

Computer Vision and Pattern Recognition · Computer Science 2020-09-04 Richard J. Chen , Ming Y. Lu , Jingwen Wang , Drew F. K. Williamson , Scott J. Rodig , Neal I. Lindeman , Faisal Mahmood

A carefully constructed scatterplot can reveal plenty about an underlying data set. However, in most cases visually mining and understanding a large multivariate data set requires more finesse, and greater level of interactivity to really…

Human-Computer Interaction · Computer Science 2016-01-27 Santiago V. Lombeyda

This paper proposes a web-based visual graph analytics platform for interactive graph mining, visualization, and real-time exploration of networks. GraphVis is fast, intuitive, and flexible, combining interactive visualizations with…

Social and Information Networks · Computer Science 2015-02-03 Nesreen K. Ahmed , Ryan A. Rossi

We show how field- and information theory can be used to quantify the relationship between genotype and phenotype in cases where phenotype is a continuous variable. Given a sample population of phenotype measurements, from various known…

Quantitative Methods · Quantitative Biology 2022-06-10 Jonathan Wattis , Sian Bray , Panagiota Kyratzi , Cyril Rauch

Human-Object Interaction (HOI) detection devotes to learn how humans interact with surrounding objects via inferring triplets of < human, verb, object >. However, recent HOI detection methods mostly rely on additional annotations (e.g.,…

Computer Vision and Pattern Recognition · Computer Science 2020-07-15 Dongming Yang , Yuexian Zou

Many visualization techniques have been created to explain the behavior of computer vision models, but they largely consist of static diagrams that convey limited information. Interactive visualizations allow users to more easily interpret…

Computer Vision and Pattern Recognition · Computer Science 2023-12-19 Devon Ulrich , Ruth Fong

Many rare genetic diseases exhibit recognizable facial phenotypes, which are often used as diagnostic clues. However, current facial phenotype diagnostic models, which are trained on image datasets, have high accuracy but often suffer from…

Quantitative Methods · Quantitative Biology 2025-04-21 Jie Song , Mengqiao He , Shumin Ren , Bairong Shen

It is common to compare state changes of multiple data items and identify which data items have changed more in various applications (e.g., annual GDP growth of different countries and daily increase of new COVID-19 cases in different…

Human-Computer Interaction · Computer Science 2024-06-21 Shaolun Ruan , Yong Wang , Qiang Guan

Analyzing a functional genomics experiment, such as ATAC-, ChIP- or RNA-sequencing, requires reference data including a genome assembly and gene annotation. These resources can generally be retrieved from different organizations and in…

Genomics · Quantitative Biology 2022-09-05 Siebren Frölich , Maarten van der Sande , Tilman Schäfers , Simon J. van Heeringen

Interactive visualization of large scholarly knowledge graphs combined with LLM reasoning shows promise butremains under-explored. We address this gap by developing an interactive visualization system for the Cell Map forAI Talent Knowledge…

Digital Libraries · Computer Science 2025-08-28 Jiawei Xu , Juichien Chen , Yilin Ye , Zhandos Sembay , Swathi Thaker , Pamela Payne-Foster , Jake Chen , Ying Ding