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Principal component analysis (PCA) is routinely used in population genetics to assess genetic structure. With chromosomal reference genomes and population-scale whole genome-sequencing becoming increasingly accessible, contemporary studies…

Populations and Evolution · Quantitative Biology 2025-01-22 L. Moritz Blumer , Jeffrey M. Good , Richard Durbin

Background: Haplotypes, the ordered lists of single nucleotide variations that distinguish chromosomal sequences from their homologous pairs, may reveal an individual's susceptibility to hereditary and complex diseases and affect how our…

Social and Information Networks · Computer Science 2019-11-28 Abishek Sankararaman , Haris Vikalo , François Baccelli

Retrieving targeted pathways in biological knowledge bases, particularly when incorporating wet-lab experimental data, remains a challenging task and often requires downstream analyses and specialized expertise. In this paper, we frame this…

Machine Learning · Computer Science 2026-04-14 Rikuto Kotoge , Ziwei Yang , Zheng Chen , Yushun Dong , Yasuko Matsubara , Jimeng Sun , Yasushi Sakurai

Based on the normal distribution and its properties, i.e., average and variance, Fisher works have provided a conceptual framework to identify genotype-phenotype associations. While Fisher intuition has proved fruitful over the past…

Populations and Evolution · Quantitative Biology 2023-07-06 Cyril Rauch , Panagiota Kyratzi , Andras Paldi

Background: Advances in high throughput sequencing technologies provide a huge number of genomes to be analyzed. Thus, computational methods play a crucial role in analyzing and extracting knowledge from the data generated. Investigating…

A large amount of research has been devoted to the detection and investigation of epistatic interactions in genome-wide association studies (GWASs). Most of the literature focuses on low-order interactions between single-nucleotide…

Applications · Statistics 2017-02-17 Virginie Stanislas , Cyril Dalmasso , Christophe Ambroise

Purpose: Development of a novel interactive visualization approach for the exploration of radiotherapy treatment plans with a focus on overlap volumes with the aim of healthy tissue sparing. Methods: We propose a visualization approach to…

Human-Computer Interaction · Computer Science 2023-10-03 Matthias Schlachter , Samuel Peters , Daniel Camenisch , Paul Martin Putora , Katja Bühler

Information Visualization (InfoVis) systems utilize visual representations to enhance data interpretation. Understanding how visual attention is allocated is essential for optimizing interface design. However, collecting Eye-tracking (ET)…

Human-Computer Interaction · Computer Science 2025-11-26 Angela Lopez-Cardona , Parvin Emami , Sebastian Idesis , Saravanakumar Duraisamy , Luis A. Leiva , Ioannis Arapakis

The advent of high-throughput sequencing technologies has lead to vast comparative genome sequences. The construction of gene-gene interaction networks or dependence graphs on the genome scale is vital for understanding the regulation of…

Methodology · Statistics 2023-03-06 Xinyao Fan , Harry Joe , Yongjin Park

Web-based data visualizations have become very popular for exploring data and communicating insights. Newspapers, journals, and reports regularly publish visualizations to tell compelling stories with data. Unfortunately, most…

Human-Computer Interaction · Computer Science 2023-02-16 Md Zubair Ibne Alam , Shehnaz Islam , Enamul Hoque

Gene interaction graphs aim to capture various relationships between genes and can represent decades of biology research. When trying to make predictions from genomic data, those graphs could be used to overcome the curse of dimensionality…

Genotype-phenotype (GP) maps specify how the random mutations that change genotypes generate variation by altering phenotypes, which, in turn, can trigger selection. Many GP maps share the following general properties: 1) The number of…

Populations and Evolution · Quantitative Biology 2014-02-07 Ard A Louis , Steffen Schaper

Extremal Graph Theory heavily relies on exploring bounds and inequalities between graph invariants, a task complicated by the rapid combinatorial explosion of graphs. Various tools have been developed to assist researchers in navigating…

Combinatorics · Mathematics 2026-03-31 Sébastien Bonte , Gauvain Devillez , Valentin Dusollier , Hadrien Mélot

Tabular data are central to biomedical research, from liquid biopsy and bulk and single-cell transcriptomics to electronic health records and phenotypic profiling. Unlike images or sequences, however, tabular datasets lack intrinsic spatial…

Machine Learning · Computer Science 2026-03-25 Sakib Mostafa , Tarik Massoud , Maximilian Diehn , Lei Xing , Md Tauhidul Islam

Visual compatibility is critical for fashion analysis, yet is missing in existing fashion image synthesis systems. In this paper, we propose to explicitly model visual compatibility through fashion image inpainting. To this end, we present…

Computer Vision and Pattern Recognition · Computer Science 2019-04-25 Xintong Han , Zuxuan Wu , Weilin Huang , Matthew R. Scott , Larry S. Davis

Effective visualisation of multidimensional data is crucial for generating insights. Glyph-based visualisations, which encode data dimensions onto multiple visual channels such as colour, shape, and size, provide an effective means of…

Human-Computer Interaction · Computer Science 2025-03-24 Rishabh Vishwakarma , Caroline Brophy , Catherine Hurley

Filtergraph is a web application being developed and maintained by the Vanderbilt Initiative in Data-intensive Astrophysics (VIDA) to flexibly and rapidly visualize a large variety of astronomy datasets of various formats and sizes. The…

Instrumentation and Methods for Astrophysics · Physics 2013-08-28 Dan Burger , Keivan G. Stassun , Joshua Pepper , Robert J. Siverd , Martin Paegert , Nathan M. De Lee , William H. Robinson

Inpainting, the process of filling missing or corrupted image parts, has broad applications in medical imaging. However, generating anatomically accurate synthetic polyp images for clinical AI is a largely underexplored problem. In…

Computer Vision and Pattern Recognition · Computer Science 2026-04-14 Duy-Bao Bui , Hoang-Khang Nguyen , Thao Thi Phuong Dao , Kim Anh Phung , Tam V. Nguyen , Justin Zhan , Minh-Triet Tran , Trung-Nghia Le

With the recent advent of high-throughput genotyping techniques, genetic data for genome-wide association studies (GWAS) have become increasingly available, which entails the development of efficient and effective statistical approaches.…

Applications · Statistics 2015-02-04 Jiahan Li , Wei Zhong , Runze Li , Rongling Wu

The surge in high-throughput omics data has reshaped the landscape of biological research, underlining the need for powerful, user-friendly data analysis and interpretation tools. This paper presents GenoCraft, a web-based comprehensive…

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