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When an individual's DNA is sequenced, sensitive medical information becomes available to the sequencing laboratory. A recently proposed way to hide an individual's genetic information is to mix in DNA samples of other individuals. We…

Information Theory · Computer Science 2024-11-05 Kayvon Mazooji , Roy Dong , Ilan Shomorony

Genome sequencing technology has advanced at a rapid pace and it is now possible to generate highly-detailed genotypes inexpensively. The collection and analysis of such data has the potential to support various applications, including…

Cryptography and Security · Computer Science 2015-06-18 Muhammad Naveed , Erman Ayday , Ellen W. Clayton , Jacques Fellay , Carl A. Gunter , Jean-Pierre Hubaux , Bradley A. Malin , XiaoFeng Wang

The goal of homomorphic encryption is to encrypt data such that another party can operate on it without being explicitly exposed to the content of the original data. We introduce an idea for a privacy-preserving transformation on natural…

Computation and Language · Computer Science 2020-05-28 Zhifeng Hu , Serhii Havrylov , Ivan Titov , Shay B. Cohen

Current techniques in sequencing a genome allow a service provider (e.g. a sequencing company) to have full access to the genome information, and thus the privacy of individuals regarding their lifetime secret is violated. In this paper, we…

Genomics · Quantitative Biology 2018-11-28 Ali Gholami , Mohammad Ali Maddah-Ali , Seyed Abolfazl Motahari

Data obfuscation deals with the problem of masking a data-set in such a way that the utility of the data is maximized while minimizing the risk of the disclosure of sensitive information. To protect data we address some ways that may as…

Cryptography and Security · Computer Science 2023-04-17 Saswata Naha , Sayantan Roy , Arkaprava Sanki , Diptanil Santra

Over the past several years, DNA sequencing has emerged as one of the driving forces in life-sciences, paving the way for affordable and accurate whole genome sequencing. As genomes represent the entirety of an organism's hereditary…

Cryptography and Security · Computer Science 2015-02-17 Emiliano De Cristofaro

Protecting the privacy of data-sets has become hugely important these days. Many real-life data-sets like income data, medical data need to be secured before making it public. However, security comes at the cost of losing some useful…

Methodology · Statistics 2018-07-16 Debolina Ghatak , Bimak K Roy

Motivated by the growing availability of personal genomics services, we study an information-theoretic privacy problem that arises when sharing genomic data: a user wants to share his or her genome sequence while keeping the genotypes at…

Information Theory · Computer Science 2021-10-18 Fangwei Ye , Hyunghoon Cho , Salim El Rouayheb

Sharing genome data in a privacy-preserving way stands as a major bottleneck in front of the scientific progress promised by the big data era in genomics. A community-driven protocol named genomic data-sharing beacon protocol has been…

Cryptography and Security · Computer Science 2020-08-25 Kerem Ayoz , Erman Ayday , A. Ercument Cicek

We live in a period where bio-informatics is rapidly expanding, a significant quantity of genomic data has been produced as a result of the advancement of high-throughput genome sequencing technology, raising concerns about the costs…

Quantitative Methods · Quantitative Biology 2023-03-10 Mehedi Hasan Sarkar , Adnan Ferdous Ashrafi

Motivation: Human genomic datasets often contain sensitive information that limits use and sharing of the data. In particular, simple anonymisation strategies fail to provide sufficient level of protection for genomic data, because the data…

Quantitative Methods · Quantitative Biology 2019-08-27 Teppo Niinimäki , Mikko Heikkilä , Antti Honkela , Samuel Kaski

Protection of the sensitive content is crucial for extensive information sharing. We present a technique of information concealing, based on introduction and maintenance of families of repeats. Repeats in DNA constitute a basic obstacle for…

Information Theory · Computer Science 2009-04-29 Lukas Kencl , Martin Loebl

With the reduction of sequencing costs and the pervasiveness of computing devices, genomic data collection is continually growing. However, data collection is highly fragmented and the data is still siloed across different repositories.…

Cryptography and Security · Computer Science 2022-03-14 Leonard Dervishi , Xinyue Wang , Wentao Li , Anisa Halimi , Jaideep Vaidya , Xiaoqian Jiang , Erman Ayday

Large genomic datasets are now created through numerous activities, including recreational genealogical investigations, biomedical research, and clinical care. At the same time, genomic data has become valuable for reuse beyond their…

Cryptography and Security · Computer Science 2021-12-28 Rajagopal Venkatesaramani , Zhiyu Wan , Bradley A. Malin , Yevgeniy Vorobeychik

Sequential data is everywhere, and it can serve as a basis for research that will lead to improved processes. For example, road infrastructure can be improved by identifying bottlenecks in GPS data, or early diagnosis can be improved by…

Cryptography and Security · Computer Science 2020-02-25 Sigal Shaked , Lior Rokach

A hypercomplex representation of DNA is proposed to facilitate comparison of DNA sequences with fuzzy composition. Using hypercomplex number representation, conventional sequence analysis method, such as, dot matrix analysis, dynamic…

Quantitative Methods · Quantitative Biology 2023-08-03 Jian-Jun Shu , Yajing Li

Access to genomic data is highly regulated due to its sensitive nature. While safeguards are essential, cumbersome data access processes pose a significant barrier to the development of AI methods for genomics. Synthetic data generation can…

Cryptography and Security · Computer Science 2026-05-01 Daniil Filienko , Martine De Cock , Sikha Pentyala

In this paper, we consider the problem of answering count queries for genomic data subject to perfect privacy constraints. Count queries are often used in applications that collect aggregate (population-wide) information from biomedical…

Cryptography and Security · Computer Science 2023-07-04 Bo Jiang , Mohamed Seif , Ravi Tandon , Ming Li

Rapid advances in human genomics are enabling researchers to gain a better understanding of the role of the genome in our health and well-being, stimulating hope for more effective and cost efficient healthcare. However, this also prompts a…

Cryptography and Security · Computer Science 2018-08-20 Alexandros Mittos , Bradley Malin , Emiliano De Cristofaro

The collection and sharing of genomic data are becoming increasingly commonplace in research, clinical, and direct-to-consumer settings. The computational protocols typically adopted to protect individual privacy include sharing summary…

Cryptography and Security · Computer Science 2023-02-06 Rajagopal Venkatesaramani , Zhiyu Wan , Bradley A. Malin , Yevgeniy Vorobeychik
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