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Unstable dynamics characterizes the evolution of most solid tumors. Because of an increased failure of maintaining genome integrity, a cumulative increase in the levels of gene mutation and loss is observed. Previous work suggests that…

Biological Physics · Physics 2015-06-18 Daniel R. Amor , Ricard V. Solé

The inflow problem for the full two-phase model in a half line is investigated in this paper. The existence and uniqueness of the stationary solution is shown by applications of center manifold theory, and its nonlinear stablility of the…

Analysis of PDEs · Mathematics 2021-08-25 Hai-Liang Li , Shuang Zhao

Cancer is a disease that takes millions of lives every year. Then, to propose treatments, avoid recurrence, and improve the patient's life quality, we need to analyze this disease from a biophysical perspective with a solid mathematical…

Quantitative Methods · Quantitative Biology 2024-07-09 Carlos M. Nieto , Oscar M. Pimentel , Fabio D. Lora-Clavijo

We study a stochastic phase-field model for tumor growth dynamics coupling a stochastic Cahn-Hilliard equation for the tumor phase parameter with a stochastic reaction-diffusion equation governing the nutrient proportion. We prove strong…

Analysis of PDEs · Mathematics 2021-01-19 Carlo Orrieri , Elisabetta Rocca , Luca Scarpa

We report on a simple model of spatial extend anti-tumor system with a fluctuation in growth rate, which can undergo a nonequilibrium phase transition. Three states as excited, sub-excited and non-excited states of a tumor are defined to…

Biological Physics · Physics 2009-11-11 Wei-Rong Zhong , Yuan-Zhi Shao , Zhen-Hui He

We propose a diffuse interface model to describe tumor as a multicomponent deformable porous medium. We include mechanical effects in the model by coupling the mass balance equations for the tumor species and the nutrient dynamics to a…

Analysis of PDEs · Mathematics 2021-09-23 Pavel Krejci , Elisabetta Rocca , Juergen Sprekels

We consider a free boundary problem for a system of PDEs, modeling the growth of a biological tissue. A morphogen, controlling volume growth, is produced by specific cells and then diffused and absorbed throughout the domain. The geometric…

Analysis of PDEs · Mathematics 2017-11-22 Alberto Bressan , Marta Lewicka

In this work, we analyze a diffuse-interface model for tumor growth, subject to multiplicative white noises, posed on a bounded domain $\mathcal{O} \subset \mathbb{R}^d$, $d=2,3$. The model couples a stochastic incompressible convective…

Analysis of PDEs · Mathematics 2026-05-29 Kalpana Rawat , Kumarasamy Sakthivel

We consider a particular phase field system which physical context is that of tumor growth dynamics. The model we deal with consists of a Cahn-Hilliard type equation governing the evolution of the phase variable which takes into account the…

Analysis of PDEs · Mathematics 2019-08-30 Andrea Signori

The aim of this paper is to investigate the asymptotic behavior of a biphase tumor fluid flow derived by 2-scale homogenisation techniques in recent works. This biphase fluid flow model accounts for the capillary wall permeability, and the…

Analysis of PDEs · Mathematics 2021-01-12 Cristina Vaghi , Sébastien Benzekry , Clair Poignard

We study an initial-boundary value problem (IBVP) for a coupled Cahn-Hilliard-Hele-Shaw system that models tumor growth. For large initial data with finite energy, we prove global (local resp.) existence, uniqueness, higher order spatial…

Analysis of PDEs · Mathematics 2012-05-31 John Lowengrub , Edriss S. Titi , Kun Zhao

In our work we study non-variational, nonlinear singularly perturbed elliptic models enjoying a double degeneracy character with prescribed boundary value in a domain. In such a scenario, we establish the existence of solutions. We also…

Analysis of PDEs · Mathematics 2024-04-17 João V. Silva , Elzon C. Júnior , Gleydson C. Ricarte

We establish the existence of a stable foliation in the vicinity of a traveling front solution for systems of reaction diffusion equations in one space dimension that arise in the study of chemical reactions models and solid fuel…

Dynamical Systems · Mathematics 2016-07-11 Yuri Latushkin , Roland Schnaubelt , Xinyao Yang

We present a fully discrete stability analysis of the domain-of-dependence stabilization for hyperbolic problems. The method aims to address issues caused by small cut cells by redistributing mass around the neighborhood of a small cut cell…

Numerical Analysis · Mathematics 2026-05-07 Louis Petri , Gunnar Birke , Christian Engwer , Hendrik Ranocha

We propose a numerical method to approximate viscosity solutions of fully nonlinear free transmission problems. The method discretises a two-layer regularisation of a PDE, involving a functional and a vanishing parameter. The former is…

Numerical Analysis · Mathematics 2025-09-18 Edgard A. Pimentel , Ercília Sousa

Contraction-driven self-propulsion of a large class of living cells can be modeled by a Keller-Segel system with free boundaries. The ensuing "active" system, exhibiting both dissipation and anti-dissipation, features stationary and…

Analysis of PDEs · Mathematics 2024-11-20 Leonid Berlyand , C. Alex Safsten , Lev Truskinovsky

We study existence of solutions in the variational sense for a class of stochastic phase-field models describing moving boundary problems. The models consist of stochastic reaction-diffusion equations with singular diffusion forced by a…

Probability · Mathematics 2026-01-12 Amjad Saef , Wilhelm Stannat

This paper is concerned with the existence and the regularity of global solutions to the linear wave equation associated with two-point type boundary conditions. We also investigate the decay properties of the global solutions to this…

Analysis of PDEs · Mathematics 2011-11-29 Le Xuan Truong , Le Thi Phuong Ngoc , Alain Pham Ngoc Dinh , Nguyen Thanh Long

In this paper we focus the attention on free boundary problems ruled by partial differential equations with nonstandard growth, presenting in particular some recent results. The interest in these problems stems from the diverse applications…

Analysis of PDEs · Mathematics 2026-03-17 Fausto Ferrari , Monica Jacob , Claudia Lederman

In this paper, we analyse a model for the growth of three-dimensional walled cells. In this model the biomechanical expansion of the cell is coupled with the geometry of its wall. We consider that the density of building material depends on…

Analysis of PDEs · Mathematics 2015-02-20 Vincent Calvez , Laetitia Giraldi