English

Optimal control of stochastic phase-field models related to tumor growth

Analysis of PDEs 2021-01-19 v1 Optimization and Control Probability

Abstract

We study a stochastic phase-field model for tumor growth dynamics coupling a stochastic Cahn-Hilliard equation for the tumor phase parameter with a stochastic reaction-diffusion equation governing the nutrient proportion. We prove strong well-posedness of the system in a general framework through monotonicity and stochastic compactness arguments. We introduce then suitable controls representing the concentration of cytotoxic drugs administered in medical treatment and we analyze a related optimal control problem. We derive existence of an optimal strategy and deduce first-order necessary optimality conditions by studying the corresponding linearized system and the backward adjoint system.

Keywords

Cite

@article{arxiv.1908.00306,
  title  = {Optimal control of stochastic phase-field models related to tumor growth},
  author = {Carlo Orrieri and Elisabetta Rocca and Luca Scarpa},
  journal= {arXiv preprint arXiv:1908.00306},
  year   = {2021}
}

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39 pages