Related papers: Lagerkvist versus Crick
Lamina-associated domains (LADs) cover a large part of the human genome and are thought to play a major role in shaping the nuclear architectural landscape. Here, we perform polymer simulations, microscopy and mass spectrometry to dissect…
Kramers degeneracy theorem is one of the basic results in quantum mechanics. According to it, the time-reversal symmetry makes each energy level of a half-integer spin system at least doubly degenerate, meaning the absence of transitions or…
Maintenance of sexual reproduction and genetic recombination imposes physiological costs when compared to parthenogenic reproduction, most prominently: for maintaining the corresponding (molecular) machinery, for finding a mating partner,…
Convergent evolution provides powerful evidence for natural selection, yet its molecular basis is typically sought in protein-coding amino acid substitutions. Whether adaptive pressures can drive the convergent evolution of synonymous codon…
The SUSY flavor, CP, gravitino and proton-decay problems are all solved to varying degrees by a decoupling solution wherein first/second generation matter scalars would exist in the multi-TeV regime. Recent models of natural SUSY presumably…
We study toric degenerations of opposite Schubert and Richardson varieties inside degenerations of Grassmannians and flag varieties. These degenerations are parametrized by matching fields in the sense of Sturmfels and Zelevinsky. We…
The complexity of a neuronal cell shape is known to be related to its function. Specifically, among other indicators, a decreased complexity in the dendritic trees of cortical pyramidal neurons has been associated with mental retardation.…
Deciphering cell type heterogeneity is crucial for systematically understanding tissue homeostasis and its dysregulation in diseases. Computational deconvolution is an efficient approach estimating cell type abundances from a variety of…
The drift-barrier hypothesis states that random genetic drift constrains the refinement of a phenotype under natural selection. The influence of effective population size and the genome-wide deleterious mutation rate were studied…
There are a number of diverging hypotheses about the neural text degeneration problem, i.e., generating repetitive and dull loops, which makes this problem both interesting and confusing. In this work, we aim to advance our understanding by…
The explanation is that in aortic tissue (both diseased and nondiseased) a BAK1 pseudogene is expressed; while in the matching blood samples the actual BAK1 gene is expressed. This explanation was reached after we realized that BAK1 has two…
The hidden symmetry of certain nano-magnets leads to many of the levels being doubly degenerate for periodic values of the Zeeman energy. Corresponding to such a symmetry is an operator, $K_{n}$, related to the time reversal operator, and…
The genesis of the stand genetic code is considered as a result of a fusion of two AU- and GC-codes distributed in two dominant and two recessive domains. The fusion of these codes is described with simple empirical rules. This formal…
Kramers' theorem ensures double degeneracy in the energy spectrum of a time-reversal symmetric fermionic system with half-integer total spin. Here we are now trying to go beyond the closed system and discuss Kramers' degeneracy in open…
Recent work has proven the existence of extreme inbreeding in a European ancestry sample taken from the contemporary UK population \cite{nature_01}. This result brings our attention again to a math problem related to inbreeding family trees…
We introduce a new symmetry, Light-Cone Reflection (LCR), which interchanges timelike and spacelike intervals. Our motivation is to provide a reason, based on symmetry, why tachyons might exist, with emphasis on application to neutrinos. We…
Networks of gene regulation govern morphogenesis, determine cell identity and regulate cell function. But we have little understanding, at the local level, of which logics are biologically preferred or even permitted. To solve this puzzle,…
Benkart, Sottile, and Stroomer have completely characterized by Knuth and dual Knuth equivalence a bijective proof of the conjugation symmetry of the Littlewood-Richardson coefficients. Tableau-switching provides an algorithm to produce…
Human aging is a process controlled by both genetics and environment. Many studies have been conducted to identify a subset of genes related to aging from the human genome. Biologists implicitly categorize age-related genes into genes that…
More than 30 years ago, we published a paper entitled as abnormal chromatin configuration and oncogenesis, which proposed the first hypothesis that links oncogenesis to abnormal three-dimensional (3D) genome structure. Recently, many…