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Highly confined vectorial electromagnetic field distributions represent an excellent tool for detailed studies in nano-optics and high resolution microscopy, such as nonlinear microscopy, advanced fluorescence imaging or nanoplasmonics.…

Optics · Physics 2014-07-03 Thomas Bauer , Sergej Orlov , Ulf Peschel , Peter Banzer , Gerd Leuchs

Fluorescence microscopic imaging in centimeter-deep tissue has been highly sought-after for many years because much interesting in vivo micro-information, such as microcirculation, tumor angiogenesis, and metastasis, may deeply locate in…

The photo-kinetics of fluorescent molecules have enabled the circumvention of far-field optical diffraction-limit. Despite its enormous potential, the necessity to label the sample may adversely influence the delicate biology under…

Silicon-based photonic biosensors, such as microring resonators and Mach-Zehnder interferometers, offer significant potential for the detection of analytes at low concentrations. To enhance response time and improve the limit of detection…

Optics · Physics 2024-07-01 Anders Henriksson , Peter Neubauer , Mario Birkholz

Single-molecule approaches to biology offer a powerful new vision to elucidate the mechanisms that underpin the functioning of living cells. However, conventional optical single molecule spectroscopy techniques such as F\"orster…

In fiber-based spectroscopy within telescopes, a prevailing limitation has been the necessity to align the fiber diameter with the telescope's seeing conditions, often characterized by the Full Width at Half Maximum of the point spread…

Instrumentation and Methods for Astrophysics · Physics 2024-06-25 Nitish Singh , S. Sriram , Bharat Kumar Yerra , Prasanna G. Deshmukh

Allying high-resolution with a large field-of-view (FOV) is of great importance in the fields of biology and medicine, but particularly challenging when imaging non-flat living samples such as the human retina. Indeed, high-resolution is…

The determination of minority-carrier lifetimes and surface recombination velocities is essential for the development of semiconductor technologies such as solar cells. The recent development of two-photon time-resolved microscopy allows…

Materials Science · Physics 2016-03-28 Benoit Gaury , Paul Haney

We demonstrate a new computational illumination technique that achieves large space-bandwidth-time product, for quantitative phase imaging of unstained live samples in vitro. Microscope lenses can have either large field of view (FOV) or…

Optics · Physics 2015-10-16 Lei Tian , Ziji Liu , Li-Hao Yeh , Michael Chen , Jingshan Zhong , Laura Waller

We introduce a new, highly sensitive, and simple heterodyne optical method for imaging individual nonfluorescent nanoclusters and nanocrystals. A 2 order of magnitude improvement of the signal is achieved compared to previous methods. This…

Optics · Physics 2007-05-23 Stéphane Berciaud , Laurent Cognet , Gerhard A Blab , Brahim Lounis

Optical imaging plays a critical role in advancing our understanding of three dimensional dynamics of biological systems. Coherent imaging (CI) methods exploit spatial phase information, encoded through propagation of coherent signal light…

Optics · Physics 2015-07-24 Jeffrey J. Field , David G. Winters , Randy A. Bartels

Fluorescence Correlation Spectroscopy (FCS) is a powerful single-molecule technique which allows for measuring motion (diffusion, flow), concentration, and molecular interaction kinetics of fluorescent molecules from picomolar to micromolar…

We describe a high-speed interferometric method, using multiple angles of incidence and multiple wavelengths, to measure the absolute thickness, tilt, the local angle between the surfaces, and the refractive index of a fluctuating…

Optics · Physics 2020-08-26 Mengfei He , Sidney R. Nagel

Optical metasurfaces have developed as a breakthrough concept for advanced wave-front engineering enabled by subwavelength resonant nanostructures. However, reflection and/or absorption losses as well as low polarisation-conversion…

Photoluminesce (PL) spectroscopy offers excellent methods for mapping the PL decay on the nanosecond time scale. However, capturing maps of emission dynamics on the microsecond time scale can be highly time-consuming. We present a new…

Optics · Physics 2021-02-24 Jiri Junek , Karel Zidek

We propose and numerically demonstrate a technique for subwavelength imaging based on a metal-dielectric multilayer hyperlens designed in such a way that only the large-wavevector waves are transmitted while all propagating waves from the…

Optics · Physics 2015-10-28 Taavi Repän , Andrei V. Lavrinenko , Sergei V. Zhukovsky

Super-resolution fluorescence microscopy is an important tool in biomedical research for its ability to discern features smaller than the diffraction limit. However, due to its difficult implementation and high cost, the universal…

Nanophotonic devices excel at confining light into intense hot spots of the electromagnetic near fields, creating unprecedented opportunities for light-matter coupling and surface-enhanced sensing. Recently, all-dielectric metasurfaces with…

A novel full-field surface profilometer using diffractive-based chromatic confocal microscopy and area-scan spectral sensing is developed. A normalized cross correlation algorithm was developed to establish a spectrum-depth response curve.…

Optics · Physics 2019-04-24 Duc Trung Nguyen , Liang-Chia Chen

This paper presents the results of a Fresnel Interferometric Array testbed. This new concept of imager involves diffraction focussing by a thin foil, in which many thousands of punched subapertures form a pattern related to a Fresnel zone…

Astrophysics · Physics 2008-08-07 Denis Serre , Laurent Koechlin , Paul Deba
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