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Evolutionary scenarios displaying reticulation events are often represented by rooted phylogenetic networks. Due to biological reasons, those events occur very rarely, and, thus, networks containing a minimum number of such events,…

Populations and Evolution · Quantitative Biology 2015-12-18 Benjamin Albrecht

Reconciling a gene tree with a species tree is an important task that reveals much about the evolution of genes, genomes, and species, as well as about the molecular function of genes. A wide array of computational tools have been devised…

Populations and Evolution · Quantitative Biology 2012-12-11 Yun Yu , Luay Nakhleh

We show that the problem of computing the hybridization number of two rooted binary phylogenetic trees on the same set of taxa X has a constant factor polynomial-time approximation if and only if the problem of computing a minimum-size…

Combinatorics · Mathematics 2011-12-23 Steven Kelk , Leo van Iersel , Nela Lekic , Simone Linz , Celine Scornavacca , Leen Stougie

Given a finite set $X$, a collection $\mathcal{T}$ of rooted phylogenetic trees on $X$ and an integer $k$, the Hybridization Number problem asks if there exists a phylogenetic network on $X$ that displays all trees from $\mathcal{T}$ and…

Discrete Mathematics · Computer Science 2016-03-23 Leo van Iersel , Steven Kelk , Celine Scornavacca

We study the problem of finding a temporal hybridization network for a set of phylogenetic trees that minimizes the number of reticulations. First, we introduce an FPT algorithm for this problem on an arbitrary set of $m$ binary trees with…

Data Structures and Algorithms · Computer Science 2022-11-09 Sander Borst , Leo van Iersel , Mark Jones , Steven Kelk

We present new and improved fixed-parameter algorithms for computing maximum agreement forests (MAFs) of pairs of rooted binary phylogenetic trees. The size of such a forest for two trees corresponds to their subtree prune-and-regraft…

Populations and Evolution · Quantitative Biology 2015-03-19 Chris Whidden , Robert G. Beiko , Norbert Zeh

Phylogenetic networks are leaf-labelled directed acyclic graphs that are used to describe non-treelike evolutionary histories and are thus a generalization of phylogenetic trees. The hybridization number of a phylogenetic network is the sum…

Data Structures and Algorithms · Computer Science 2016-06-01 Leo van Iersel , Steven Kelk , Nela Lekić , Chris Whidden , Norbert Zeh

{\em Reoptimization} is a setting in which we are given an (near) optimal solution of a problem instance and a local modification that slightly changes the instance. The main goal is that of finding an (near) optimal solution of the…

Data Structures and Algorithms · Computer Science 2018-05-01 Davide Bilò

Full binary trees naturally represent commutative non-associative products. There are many important examples of these products: finite-precision floating-point addition and NAND gates, among others. Balance in such a tree is highly…

Discrete Mathematics · Computer Science 2021-08-27 Laura Monroe

We present the first fixed-parameter algorithm for constructing a tree-child phylogenetic network that displays an arbitrary number of binary input trees and has the minimum number of reticulations among all such networks. The algorithm…

Discrete Mathematics · Computer Science 2019-07-22 Leo van Iersel , Remie Janssen , Mark Jones , Yukihiro Murakami , Norbert Zeh

Determining the interaction partners among protein/domain families poses hard computational problems, in particular in the presence of paralogous proteins. Available approaches aim to identify interaction partners among protein/domain…

Populations and Evolution · Quantitative Biology 2015-01-14 Iman Hajirasouliha , Alexander Schönhuth , David Juan , Alfonso Valencia , S. Cenk Sahinalp

We present efficient algorithms for computing a maximum agreement forest (MAF) of a pair of multifurcating (nonbinary) rooted trees. Our algorithms match the running times of the currently best algorithms for the binary case. The size of an…

Data Structures and Algorithms · Computer Science 2013-05-03 Chris Whidden , Robert G. Beiko , Norbert Zeh

It is a known fact that, given two rooted binary phylogenetic trees, the concept of maximum acyclic agreement forests is sufficient to compute hybridization networks with minimum hybridization number. In this work, we demonstrate by first…

Populations and Evolution · Quantitative Biology 2015-12-18 Benjamin Albrecht

Given two rooted phylogenetic trees on the same set of taxa X, the Maximum Agreement Forest problem (MAF) asks to find a forest that is, in a certain sense, common to both trees and has a minimum number of components. The Maximum Acyclic…

Combinatorics · Mathematics 2012-12-27 Leo van Iersel , Steven Kelk , Nela Lekić , Leen Stougie

We initiate a systematic study of utilizing predictions to improve over approximation guarantees of classic algorithms, without increasing the running time. We propose a systematic method for a wide class of optimization problems that ask…

Data Structures and Algorithms · Computer Science 2024-11-26 Antonios Antoniadis , Marek Eliáš , Adam Polak , Moritz Venzin

It has recently been shown that the NP-hard problem of calculating the minimum number of hybridization events that is needed to explain a set of rooted binary phylogenetic trees by means of a hybridization network is fixed-parameter…

Populations and Evolution · Quantitative Biology 2012-03-20 Leo van Iersel , Simone Linz

A common problem in phylogenetics is to try to infer a species phylogeny from gene trees. We consider different variants of this problem. The first variant, called Unrestricted Minimal Episodes Inference, aims at inferring a species tree…

Populations and Evolution · Quantitative Biology 2019-08-12 Leo van Iersel , Remie Janssen , Mark Jones , Yukihiro Murakami , Norbert Zeh

We present new algorithms and fast implementations to find efficient approximations for modelling stochastic processes. For many numerical computations it is essential to develop finite approximations for stochastic processes. While the…

Optimization and Control · Mathematics 2020-12-03 Kipngeno Benard Kirui , Georg Ch. Pflug , Alois Pichler

Reconstructing a parsimonious phylogenetic network that displays multiple phylogenetic trees is an important problem in theory of phylogenetics, where the complexity of the inferred networks is measured by reticulation numbers. The…

Populations and Evolution · Quantitative Biology 2024-08-27 Yufeng Wu , Louxin Zhang

Here we present a new fixed parameter tractable algorithm to compute the hybridization number r of two rooted, not necessarily binary phylogenetic trees on taxon set X in time (6^r.r!).poly(n)$, where n=|X|. The novelty of this approach is…

Quantitative Methods · Quantitative Biology 2012-07-26 Teresa Piovesan , Steven Kelk
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