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Polymer translocation through a nanopore in a membrane investigated theoretically. Recent experiments on voltage-driven DNA and RNA translocations through a nanopore indicate that the size and geometry of the pore are important factors in…

Statistical Mechanics · Physics 2009-11-07 Elena Slonkina , Anatoly B. Kolomeisky

In this work we study the assisted translocation of a polymer across a membrane nanopore, inside which a molecular motor exerts a force fuelled by the hydrolysis of ATP molecules. In our model the motor switches to its active state for a…

Soft Condensed Matter · Physics 2018-03-26 A. Fiasconaro , J. J. Mazo , F. Falo

We investigate the translocation of stiff polymers in the presence of binding particles through a nanopore by two-dimensional Langevin dynamics simulations. We find that the mean translocation time shows a minimum as a function of the…

Soft Condensed Matter · Physics 2015-06-12 Wancheng Yu , Yiding Ma , Kaifu Luo

Here using LAMMPS molecular dynamics (MD) software, we simulate polymer translocation in 2 dimensions. We do the simulations for weak and moderate forces and for different pore diameters. Our results show that in both non-equilibrium and…

Computational Physics · Physics 2018-04-26 Mohammadreza Niknam Hamidabad , Rouhollah Haji Abdolvahab

We study the passage times of a translocating polymer of length $N$ in three dimensions, while it is pulled through a narrow pore with a constant force $F$ applied to one end of the polymer. At small to moderate forces, satisfying the…

Soft Condensed Matter · Physics 2008-02-14 Debabrata Panja , Gerard T. Barkema

We employ a three-dimensional molecular dynamics to simulate translocation of a polymer through a nanopore driven by an external force. The translocation is investigated for different three pore diameter and two different external forces.…

Computational Physics · Physics 2019-12-03 Mohammadreza Niknam Hamidabad , Rouhollah Haji Abdolvahab

We study pore blockade times for a translocating polymer of length $N$, driven by a field $E$ across the pore in three dimensions. The polymer performs Rouse dynamics, i.e., we consider polymer dynamics in the absence of hydrodynamical…

Soft Condensed Matter · Physics 2008-02-15 Henk Vocks , Debabrata Panja , Gerard T. Barkema , Robin C. Ball

Using analytical techniques and Langevin dynamics simulations, we investigate the dynamics of polymer translocation through a nanochannel embedded in two dimensions under an applied external field. We examine the translocation time for…

Soft Condensed Matter · Physics 2012-03-26 Huaisong Yong , Yilin Wang , Shichen Yuan , Bi Xu , Kaifu Luo

Using Langevin dynamics simulations, we investigate the influence of polymer-pore interactions on the dynamics of biopolymer translocation through nanopores. We find that an attractive interaction can significantly change the translocation…

Soft Condensed Matter · Physics 2008-12-21 Kaifu Luo , Tapio Ala-Nissila , See-Chen Ying , Aniket Bhattacharya

One of the most fundamental quantities associated with polymer translocation through a nanopore is the translocation time $\tau$ and its dependence on the chain length $N$. Our simulation results based on both the bond fluctuation Monte…

Soft Condensed Matter · Physics 2008-11-08 Kaifu Luo , Tapio Ala-Nissila , See-Chen Ying , Pawel Pomorski , Mikko Karttunen

We analyse the dynamics of polymer translocation in the strong force regime by recasting the problem into solving a differential equation with a moving absorbing boundary. For the total translocation time, $\tau_{\rm tr}$, our simple…

Soft Condensed Matter · Physics 2007-11-01 Chiu Fan Lee

Most of the theoretical models describing the translocation of a polymer chain through a nanopore use the hypothesis that the polymer is always relaxed during the complete process. In other words, models generally assume that the…

Biomolecules · Quantitative Biology 2009-11-13 Michel G. Gauthier , Gary W. Slater

Using Langevin dynamics simulations, we investigate the dynamics of chaperone-assisted translocation of a flexible polymer through a nanopore. We find that increasing the binding energy $\epsilon$ between the chaperone and the chain and the…

Soft Condensed Matter · Physics 2011-08-26 Wancheng Yu , Kaifu Luo

We study the dynamics of the passage of a polymer through a membrane pore (translocation), focusing on the scaling properties with the number of monomers $N$. The natural coordinate for translocation is the number of monomers on one side of…

Soft Condensed Matter · Physics 2009-11-07 Jeffrey Chuang , Yacov Kantor , Mehran Kardar

Motivated by identifying the origin of the bias dependence of tension propagation we investigate methods for measuring tension propagation quantitatively in computer simulations of driven polymer translocation. Here the motion of flexible…

Biological Physics · Physics 2017-12-18 P. M. Suhonen , J. Piili , R. P. Linna

The theoretical formulation of driven polymer translocation through nanopores is complicated by the combination of the pore electrohydrodynamics and the nonequilibrium polymer dynamics originating from the conformational polymer…

Soft Condensed Matter · Physics 2019-01-15 Sahin Buyukdagli , Jalal Sarabadani , Tapio Ala-Nissila

We present a unified scaling theory for the dynamics of monomers for dilute solutions of semiflexible polymers under good solvent conditions in the free draining limit. Our theory encompasses the well-known regimes of mean square…

Soft Condensed Matter · Physics 2015-06-17 Aiqun Huang , Ramesh Adhikari , Aniket Bhattacharya , Kurt Binder

We present a numerical study of forced polymer translocation by using two separate pore models. Both of them have been extensively used in previous forced translocation studies. We show that variations in the pore model affect the forced…

Biological Physics · Physics 2015-05-19 V. V. Lehtola , K. Kaski , R. P. Linna

This paper reports the force spectroscopy analysis of a polymer that translocates from one side of a membrane to the other side through an extended pore, pulled by a cantilever that moves with constant velocity against the damping and the…

Soft Condensed Matter · Physics 2018-12-12 Alessandro Fiasconaro , Fernando Falo

We present event distributions for the polymer translocation obtained by extensive Langevin dynamics simulations. Such distributions have not been reported previously and they provide new understanding of the stochastic characteristics of…

Soft Condensed Matter · Physics 2012-04-13 R. P. Linna , K. Kaski