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Monte Carlo (MC) is generally considered as the most accurate dose calculation tool for particle therapy. However, a proper description of the beam particles kinematics is a necessary input for a realistic simulation. Such a description can…

Stereotactic body radiation therapy (SBRT) for pancreatic cancer requires a skillful approach to deliver ablative doses to the tumor while limiting dose to the highly sensitive duodenum, stomach, and small bowel. Here, we develop…

We describe initial work on an extension of the Kaldi toolkit that supports weighted finite-state transducer (WFST) decoding on Graphics Processing Units (GPUs). We implement token recombination as an atomic GPU operation in order to fully…

Computation and Language · Computer Science 2018-07-30 Zhehuai Chen , Justin Luitjens , Hainan Xu , Yiming Wang , Daniel Povey , Sanjeev Khudanpur

High radiation dose in computed tomography (CT) scans increases the lifetime risk of cancer, which become a major clinical concern. The backprojection-filtration (BPF) algorithm could reduce radiation dose by reconstructing images from…

Medical Physics · Physics 2013-11-20 Yan Bin , Deng Lin , Han Yu , Zhang Feng , Wang Xian Chao , Li Lei

Performance optimization is the art of continuous seeking a harmonious mapping between the application domain and hardware. Recent years have witnessed a surge of deep learning (DL) applications in industry. Conventional wisdom for…

Distributed, Parallel, and Cluster Computing · Computer Science 2019-11-27 Guoping Long , Jun Yang , Wei Lin

Deep learning (DL) 3D dose prediction has recently gained a lot of attention. However, the variability of plan quality in the training dataset, generated manually by planners with wide range of expertise, can dramatically effect the quality…

Computer Vision and Pattern Recognition · Computer Science 2021-06-08 Navdeep Dahiya , Gourav Jhanwar , Anthony Yezzi , Masoud Zarepisheh , Saad Nadeem

In this paper, first, a hardware-friendly pruning algorithm for reducing energy consumption and improving the speed of Long Short-Term Memory (LSTM) neural network accelerators is presented. Next, an FPGA-based platform for efficient…

Hardware Architecture · Computer Science 2021-01-08 Seyed Abolfazl Ghasemzadeh , Erfan Bank Tavakoli , Mehdi Kamal , Ali Afzali-Kusha , Massoud Pedram

Background: Scintillation dosimetry has promising qualities for ultra-high dose rate (UHDR) radiotherapy (RT), but no system has shown compatibility with mean dose rates ($\bar{DR}$) above 100 Gy/s and doses per pulse ($D_p$) exceeding 1.5…

Medical Physics · Physics 2024-03-06 Alexander Baikalov , Daline Tho , Kevin Liu , Stefan Bartzsch , Sam Beddar , Emil Schüler

Finite-difference time-domain (FDTD) simulations often involve physical quantities spanning multiple orders of magnitude, such as the speed of light or electromagnetic field amplitudes. The standard practice for maintaining numerical…

Computational Physics · Physics 2026-03-26 Yannik Mahlau , Lukas Berg , Bodo Rosenhahn

Fast and accurate dose predictions are one of the bottlenecks in treatment planning for microbeam radiation therapy (MRT). In this paper, we propose a machine learning (ML) model based on a 3D U-Net. Our approach predicts separately the…

Methods: A phase space file in a plane at 202 mm downstream of the beam exit window is generated through tuning parameters to match FDC results with measured or MCNPX Monte Carlo-simulated integrated depth-dose distribution (IDD) and…

Medical Physics · Physics 2023-01-11 Qianxia Wang , Uwe Titt , Radhe Mohan , Fada Guan , Yao Zhao , Ming Yang , Pablo Yepes

Background and Objective: Recent experimental studies using ultra-high dose rate radiation therapy (FLASH-RT) have shown improved normal tissue sparing and comparable tumor control compared to conventional dose rate RT. Pencil beam scanning…

Mixed-precision algorithms have been proposed as a way for scientific computing to benefit from some of the gains seen for artificial intelligence (AI) on recent high performance computing (HPC) platforms. A few applications dominated by…

Distributed, Parallel, and Cluster Computing · Computer Science 2025-07-16 Aditya Kashi , Nicholson Koukpaizan , Hao Lu , Michael Matheson , Sarp Oral , Feiyi Wang

The high computational cost of ab-initio methods limits their application in predicting electronic properties at the device scale. Therefore, an efficient method is needed to map the atomic structure to the electronic structure quickly.…

Materials Science · Physics 2025-09-09 Yunlong Wang , Zhixin Liang , Chi Ding , Junjie Wang , Zheyong Fan , Hui-Tian Wang , Dingyu Xing , Jian Sun

Small Angle Scattering (SAS) of X-rays or neutrons is an experimental technique that provides valuable structural information for biological macromolecules under physiological conditions and with no limitation on the molecular size. In…

Biomolecules · Quantitative Biology 2013-06-11 Konstantin Berlin , Nail A. Gumerov , Ramani Duraiswami , David Fushman

Background: Multi-collimator proton minibeam radiation therapy (MC-pMBRT) has recently emerged as a versatile technique for dose shaping, enabling peak-valley dose patterns in organs-at-risk (OAR) while maintaining a uniform dose…

Medical Physics · Physics 2025-02-25 Nimita Shinde , Weijie Zhang , Yuting Lin , Hao Gao

The Density Matrix Renormalization Group (DMRG) is a state-of-the-art numerical technique for a one dimensional quantum many-body system; but calculating accurate results for a system with Periodic Boundary Condition (PBC) from the…

Strongly Correlated Electrons · Physics 2016-11-29 Dayasindhu Dey , Debasmita Maiti , Manoranjan Kumar

Accurate prediction of rarefied gas flows is important for space vehicle design, particularly in rarefied regimes where the Navier-Stokes equations are no more valid. While the direct simulation Monte Carlo (DSMC) method acts as a numerical…

Fluid Dynamics · Physics 2025-07-01 Joonbeom Kim , Eunji Jun

Purpose: To provide a fast computational method, based on the proximal graph solver (POGS) - a convex optimization solver using the alternating direction method of multipliers (ADMM), for calculating an optimal treatment plan in rotating…

Medical Physics · Physics 2018-02-07 Myung Cho , Xiaodong Wu , Hossein Dakhah , Jirong Yi , Ryan T. Flynn , Yusung Kim , Weiyu Xu

Beam orientation optimization (BOO) is a key component in the process of IMRT treatment planning. It determines to what degree one can achieve a good treatment plan quality in the subsequent plan optimization process. In this paper, we have…

Medical Physics · Physics 2015-05-27 Xun Jia , Chunhua Men , Yifei Lou , Steve B. Jiang