Fast and accurate dose predictions are one of the bottlenecks in treatment planning for microbeam radiation therapy (MRT). In this paper, we propose a machine learning (ML) model based on a 3D U-Net. Our approach predicts separately the large doses of the narrow high intensity synchrotron microbeams and the lower valley doses between them. For this purpose, a concept of macro peak doses and macro valley doses is introduced, describing the respective doses not on a microscopic level but as macroscopic quantities in larger voxels. The ML model is trained to mimic full Monte Carlo (MC) data. Complex physical effects such as polarization are therefore automatically taking into account by the model. The macro dose distribution approach described in this study allows for superimposing single microbeam predictions to a beam array field making it an interesting candidate for treatment planning. It is shown that the proposed approach can overcome a main obstacle with microbeam dose predictions by predicting a full microbeam irradiation field in less than a minute while maintaining reasonable accuracy.
@article{arxiv.2211.11193,
title = {A step towards treatment planning for microbeam radiation therapy: fast peak and valley dose predictions with 3D U-Nets},
author = {Florian Mentzel and Micah Barnes and Kevin Kröninger and Michael Lerch and Olaf Nackenhorst and Jason Paino and Anatoly Rosenfeld and Ayu Saraswati and Ah Chung Tsoi and Jens Weingarten and Markus Hagenbuchner and Susanna Guatelli},
journal= {arXiv preprint arXiv:2211.11193},
year = {2022}
}
Comments
accepted for publication in the IFMBE Proceedings on the World Congress on Medical Physics and Biomedical Engineering 2022