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During an infection, HIV experiences strong selection by immune system T cells. Recent experimental work has shown that MHC escape mutations form an important pathway for HIV to avoid such selection. In this paper, we study a model of MHC…
The empirical literature on program evaluation limits its scope almost exclusively to models where treatment effects are homogenous for observationally identical individuals. This paper considers a treatment effect model in which treatment…
The goal of this work is to develop and analyze a reaction-diffusion model for the transmission dynamics of the Coronavirus (COVID-19) that accounts for reinfection and vaccination, as well as to compare it to the ODE model. After…
Hepatitis B virus (HBV) is considered as etiological agent of the lethal liver disease hepatitis B. Globally, hepatitis B is recognized as one of the prevailing infectious diseases with a significant impact on human health. In spite of…
In this article we suggest a new statistical approach considering survival heterogeneity as a breakpoint model in an ordered sequence of time to event variables. The survival responses need to be ordered according to a numerical covariate.…
Coupling within-host infection dynamics with population-level transmission remains a major challenge in infectious disease modeling, especially for airborne pathogens with potential to spread indoor. The frequent emergence of such diseases…
Motivated by an ongoing collaboration with clinical oncologists and pathologists, we develop a hybrid partial differential equation--ordinary differential equation (PDE--ODE) framework that captures (i) competition between susceptible and…
We consider a recent coinfection model for Tuberculosis (TB), Human Immunodeficiency Virus (HIV) infection and Acquired Immunodeficiency Syndrome (AIDS) proposed in [Discrete Contin. Dyn. Syst. 35 (2015), no. 9, 4639--4663]. We introduce…
We investigate global stability properties of a HIV/AIDS population model with constant recruitment rate, mass action incidence, and variable population size. Existence and uniqueness results for disease-free and endemic equilibrium points…
Hepatitis B is a potentially life-threatening liver infection caused by the hepatitis B virus (HBV). In this paper, the transmission dynamics of hepatitis B is formulated with a mathematical model with considerations of different classes of…
In this paper we analyze the effects of commuting and social inequalities for the epidemic development of the novel coronavirus (COVID-19). With this aim we consider a SEIRD (susceptible, exposed, infected, recovered and dead by disease)…
This paper deals with the oncolytic virotherapy model \begin{equation}\begin{split} \begin{cases} &u_t = \Delta u - \nabla \cdot (u\nabla v)-uz +\mu u(1-u),& \\[2ex] &v_t = - (u+w)v,& \\[2ex] &w_t = D_w \Delta w - w + uz,& \\[2ex] &z_t =…
Extreme enrichment of the human immunodeficiency virus (HIV-1) RNA genome for the purine A parallels the mild purine-loading of the RNAs of most organisms. This should militate against loop-loop "kissing" interactions between the structured…
We study a multi-type SIR epidemic process among a heterogeneous population that interacts through a network. When we base social contact on a random graph with given vertex degrees, we give limit theorems on the fraction of infected…
In this paper we put forward a viral propagation model with nonlinear infection rate and free boundaries and investigate the dynamical properties. This model is composed of two ordinary differential equations and one partial differential…
This paper develops an impulsive faecal-oral model with free boundary to in order to understand how the exposure to a periodic disinfection and expansion of the infected region together influences the spread of faecal-oral diseases. We…
The spread of infectious disease and the evolution of antigenically distinct strains are often modeled separately, despite strong feedbacks mediated by host immune memory and heterogeneous contacts. To tackle this challenging problem, we…
Genetic variations in the COVID-19 virus are one of the main causes of the COVID-19 pandemic outbreak in 2020 and 2021. In this article, we aim to introduce a new type of model, a system coupled with ordinary differential equations (ODEs),…
We consider a two-species reaction-diffusion system in one space dimension that is derived from an epidemiological model in a spatially periodic environment with two types of pathogens: the wild type and the mutant. The system is of a…
The fundamental models of epidemiology describe the progression of an infectious disease through a population using compartmentalized differential equations, but do not incorporate population-level heterogeneity in infection susceptibility.…