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Cytotoxic T lymphocytes (CTLs) are immune system cells that are thought to play an important role in controlling HIV infection. We develop a stochastic ODE model of HIV-CTL interaction that extends current deterministic ODE models. Based on…
In this paper, we consider a model with tumor microenvironment involving nutrient density, extracellular matrix and matrix-degrading enzymes, which satisfy a coupled system of PDEs with a free boundary. For this coupled parabolic-hyperbolic…
The subject of this paper is inspired by \cite{CC} and \cite{CCP}. In \cite{CC} the authors investigate the dynamics of a population in a heterogeneous environment by means of diffusive logistic equations. An important part of their study…
Human mobility, contact patterns, and their interplay are key aspects of our social behavior that shape the spread of infectious diseases across different regions. In the light of new evidence and data sets about these two elements,…
In this study, we develop and analyze a nested multi-scale model for COVID -19 disease that integrates within-host scale and between-host scale sub-models. First, the well-posedness of the multi-scale model is discussed, followed by the…
Partial differential equation (PDE) models for infectious diseases, while less common than their ordinary differential equation (ODE) counterparts, have found successful applications for many years. Such models are typically of…
Viral deep-sequencing data play a crucial role toward understanding disease transmission network flows, because the higher resolution of these data compared to standard Sanger sequencing provide evidence into the direction of infectious…
We discuss methods for {\em a priori} selection of parameters to be estimated in inverse problem formulations (such as Maximum Likelihood, Ordinary and Generalized Least Squares) for dynamical systems with numerous state variables and an…
A class of stochastic vector-borne infectious disease models is derived and studied. The class type is determined by a general nonlinear incidence rate of the disease. The disease spreads in a highly random environment with variability from…
This paper considers the problem of modeling epidemic outbreaks in different regions with a common model, that uses additional information about these regions to adjust its parameters and relieve us of mundanity of data collecting, and…
The paper deals with the analysis of a discrete-time networked competitive bivirus susceptible-infected-susceptible (SIS) model. More specifically, we suppose that virus 1 and virus 2 are circulating in the population and are in competition…
As pathogens spread in a population of hosts, immunity is built up and the pool of susceptible individuals is depleted. This generates selective pressure, to which many human RNA viruses, such as influenza virus or SARS-CoV-2, respond with…
Variational autoencoders (VAEs), as well as other generative models, have been shown to be efficient and accurate for capturing the latent structure of vast amounts of complex high-dimensional data. However, existing VAEs can still not…
We present a general framework for analyzing spatially inhomogeneous cosmological dynamics. It employs Hubble-normalized scale-invariant variables which are defined within the orthonormal frame formalism, and leads to the formulation of…
We propose a competitive bi-virus model with dynamic social distancing behavior. Our model illustrates how public perception of different viruses changes the conditions for their eradication, their coexistence, or the dominance of one over…
In this paper we present a model describing Susceptible-Infected-Susceptible (SIS) type epidemics spreading on a dynamic contact network with random link activation and deletion where link ac- tivation can be locally constrained. We use and…
This paper is concerned with the global dynamics of a hybrid parabolic-hyperbolic model describing populations with distinct dispersal and sedentary stages. We first establish the global well-posedness of solutions, prove a comparison…
We model the spontaneous assembly of a capsid (a virus's closed outer shell) from many copies of identical units, using entirely irreversible steps and only information local to the growing edge. Our model is formulated in terms of (i) an…
We study dynamics of a variant of the SIR the model, where we assume that individuals respond differently to dynamics of the epidemic. Their heterogeneous response is modeled by the Preisach hysteresis operator. The degree of heterogeneity…
We investigate the celebrated mathematical SICA model but using fractional differential equations in order to better describe the dynamics of HIV-AIDS infection. The infection process is modelled by a general functional response and the…