Related papers: Statistical effects of dose deposition in track-st…
This paper focuses on the analytic modelling of responses of cells in the body to ionizing radiation. The related mechanisms are consecutively taken into account and discussed. A model of the dose- and time-dependent adaptive response is…
To include the bound electron effects in particle-in-cell (PIC) simulation, we propose a model in which the response of the dipole components of partially ionized ions to external electromagnetic fields can be included. Instead of treating…
The interaction of energetic ions with the electronic and ionic system of target materials is an interesting but challenging multi-scale problem and understanding of the early stages after impact of heavy, initially charged ions is…
An analytical inactivation cross section formula based on the analytical formula for calculating the radial dose distribution of Awad et al. (Awad et al., 2018) was proposed. The formula is a multi-hit model based on the track structure…
Objective: Radiolytic oxygen depletion (ROD) may play a role in the sparing of cells irradiated with ultra-high dose rates. Different methods have been used to quantify the effect of ROD during FLASH irradiation on cell survival, typically…
There is a considerable debate between research groups applying the two stage clonal expansion model for lung cancer risk estimation, whether radon exposure affects initiation and transformation or promotion. The objective of the present…
Radiation therapy with carbon ions is a novel technique of cancer radiotherapy, applicable in particular to treating radioresistant tumours at difficult localisations. Therapy planning, where the medical physicist, following the medical…
Carbon-ion radiotherapy provides high dose conformity for lung cancer, but its benefit is limited by two sources of uncertainties: interplay between scanned beam delivery and tumor motion, and dose modulation from heterogeneous lung tissue.…
We investigate the dose and dose-rate dependence of the mutation frequency caused by artificial radiations with Whack-A-Mole (WAM) model which we have recently proposed. In particular, we pay special attention to the case of long-term and…
We present an algorithm for fast and accurate computation of the local dose distribution in MeV beams of protons, carbon ions or other heavy-charged particles. It uses compound Poisson-process modelling of track interaction and succesive…
Predicting volume swelling of structural materials in nuclear reactors under high-dose neutron irradiations based on existing low-dose experiments or irradiation data with high-dose-rate energetic particles has been a long-standing…
With recent developments in simulating nonadiabatic systems to high accuracy, it has become possible to determine how much energy is attributed to nuclear quantum effects beyond zero-point energy. In this work we calculate the…
Background: Accurate and fast dose calculation is essential for optimizing carbon ion therapy. Existing machine learning (ML) models have been developed for other radiotherapy modalities. They use patient data with uniform CT imaging…
Purpose: Recent studies suggest ultra-high dose rate (FLASH) irradiation can spare normal tissues from radiotoxicity, while efficiently controlling the tumor, and this is known as the FLASH effect. This study performed theoretical analyses…
Radiotherapy is a commonly used treatment for cancer and is usually given in varying doses. At low radiation doses relatively few cells die as a direct response to radiation but secondary radiation effects such as DNA mutation or bystander…
Based on Monte Carlo (MC) simulations of the interaction of energetic noble gas ions with carbon nanostructures, we have derived the ion-deposited energy formulas and their applications for the above interaction. We also have studied the…
In radiobiological experiments, the cells can either float in suspension or adhere to the walls of the sample holder. When irradiation is performed in the presence of dose modifying agents such as gold nanoparticles (AuNPs), the different…
Relative biological effectiveness (RBE) is a key quantity for the description of radiobiological effects induced by charged-particle irradiation in the context of ion-beam cancer therapy. Since RBE is a complex function that depends on…
Ionizing radiation induces defects in STI oxides in current MOSFETs. These defects may degrade the performance of the MOS circuit. Analytical models for the buildup of these defects during the radiation exposure are available in literature.…
Concerns have been raised about possible cancer risks after exposure to computed tomography (CT) scans in childhood. The health effects of ionizing radiation are then estimated from the absorbed dose to the organs of interest which is…