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Ionizing radiation is known to delay the cell cycle progression. In particular after particle exposure significant delays have been observed and it has been shown that the extent of delay affects the expression of damage such as chromosome…

Cell Behavior · Quantitative Biology 2009-08-24 Anna Ochab-Marcinek , Ewa Gudowska-Nowak , Elena Nasonova , Sylvia Ritter

In the case of radon exposure, the spatial distribution of deposited radioactive particles is highly inhomogeneous in the central airways. The objective of this research is to investigate the consequences of this heterogeneity regarding…

Medical Physics · Physics 2014-04-23 Balázs G. Madas , Imre Balásházy , Árpád Farkas , István Szőke

Improving effective treatment plans in carbon ion therapy, especially for targeting radioresistant tumors located in deep seated regions while sparing normal tissues, depends on a precise and computationally efficient dose calculation…

Medical Physics · Physics 2025-06-25 Fulya Halıcılar , Metin Arık

In randomized dose-finding trials, although drug exposure data form a part of key information for dose selection, the evaluation of the dose-response (DR) relationship often mainly uses DR data. We examine the benefit of…

Methodology · Statistics 2025-08-07 Jixian Wang , Zhiwei Zhang , Ram Tiwari

Microdosimetric single event spectra is a significant parameter in radiotherapy, which can be used to evaluate the biological effect of radiation fields. This paper simulated microscopic patterns of energy depositions for mixed radiation…

Medical Physics · Physics 2015-02-03 Chengguo Pang , Junkui Xu , Wuyuan Li , Weiwei Yan , Zeen Yao , Youwu Su

Irradiation of cell monolayers by monoenergetic ions has made it possible to establish survival curves at individual values of linear energy transfer. The two-step model of radiobiological mechanism proposed recently by Judas and Lokajicek…

Medical Physics · Physics 2007-05-23 Pavel Kundrat , Milos Lokajicek , Hana Hromcikova

The emission line ratios [OIII]5007/H-beta and [NII]6584/H-alpha have been adopted as an empirical way to distinguish between the fundamentally different mechanisms of ionization in emission-line galaxies. However, detailed interpretation…

Cosmology and Nongalactic Astrophysics · Physics 2015-06-15 Sherry C. C. Yeh , Silvia Verdolini , Mark R. Krumholz , Christopher D. Matzner , Alexander G. G. M. Tielens

Worldwide several radiation sources contribute to the delivered dose to the human population. This radiation also acts as natural background when detecting radiation, for instance from radioactive sources. In this work a medium-size plastic…

Instrumentation and Detectors · Physics 2017-09-20 Luis Peralta

In this study, we quantify how charged particle concentration affects the neutralization rate of aerosol particles, focusing on the role of ion dynamics shaped by internal electric fields arising from net space charge. Conventional…

Chemical Physics · Physics 2025-10-22 Kunal. Ghosh , Gargi Sengupta , Rukhsar Parveen , Y. S. Mayya

Recently, Yamashita et al. reported direct measurements of ionizing radiation doses to individual organs in postmortem (using OSL dosimetry) that were exposed in the most frequent clinical CT scan protocols, corresponding to the whole body,…

FLASH radiation has been reported to efficiently suppress tumor growth while sparing normal tissue, however, the mechanism of the differential tissue sparing effect is still not known. Oxygen has long been known to profoundly impact…

Medical Physics · Physics 2022-12-29 Hongyu Zhu , Jan Schuemann , Qixian Zhang , Leo E Gerweck

Cosmic rays are a global source of ionisation, and the ionisation fraction represents a fundamental parameter in the interstellar medium. Ions couple to magnetic fields, affect the chemistry, and the dynamics of star-forming regions as well…

Astrophysics of Galaxies · Physics 2020-03-25 Stefano Bovino , Simon Ferrada-Chamorro , Alessandro Lupi , Dominik R. G. Schleicher , Paola Caselli

Our purpose is to measure the internal radiation dose (ID) using human blood sample. In the literature, there is no process that allows the direct measurement of ID received by a person. This study has shown that it is possible to determine…

The energy losses of energetic ions in materials depend on both nuclear and electronic interactions. In channeling geometries, the stopping effect of these interactions can be highly reduced, resulting in deeper ion penetration.…

We calculate the cross-section of ionization by free-electron impacts in high or moderate density plasmas. We show that the so-called ionization potential depression (IPD) strongly affects the magnitude of the cross-section in the…

Atomic Physics · Physics 2023-09-14 Djamel Benredjem , Jean-Christophe Pain , Annette Calisti , Sandrine Ferri

Understanding the nature of irradiation damage often requires a multi-scale and multi-physics approach, i.e. it requires a significant amount of information from experiments, simulations and phenomenological models. This paper focuses on…

Materials Science · Physics 2024-05-07 Bartosz Barzdajn , Christopher P Race

Previously reported nanodosimetric measurements of therapeutic-energy carbon ions penetrating simulated tissue have produced results that are incompatible with the predicted mean energy of the carbon ions in the nanodosimeter and previous…

Medical Physics · Physics 2025-10-27 Miriam Schwarze , Gerhard Hilgers , Hans Rabus

The use of dual-energy CT (DECT) potentially decreases range uncertainties in proton and ion therapy treatment planning via determination of the involved physical target quantities. For eventual clinical application, the correct treatment…

Medical Physics · Physics 2016-05-19 Christian Möhler , Patrick Wohlfahrt , Christian Richter , Steffen Greilich

Electronic effects are believed to be important in high--energy radiation damage processes where high electronic temperature is expected, yet their effects are not currently understood. Here, we perform molecular dynamics simulations of…

In this paper we develop a simple theory to study the effects of ionic size on ionic distributions around a charged spherical particle. We include a correction to the regular Poisson-Boltzmann equation in order to take into account the size…

Soft Condensed Matter · Physics 2017-08-30 Thiago Colla , Lucas Nunes Lopes , Alexandre P. dos Santos