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We use a combination of computer simulations and iso-flux tension propagation (IFTP) theory to investigate translocation dynamics of a flexible linear polymer through a nanopore into an environment composed of repulsive active rods in 2D.…

Soft Condensed Matter · Physics 2021-02-03 Hamidreza Khalilian , Jalal Sarabadani , Tapio Ala-Nissila

Using Langevin dynamics simulations, we investigate the dynamics of polymer translocation into a circular nanocontainer through a nanopore under a driving force $F$. We observe that the translocation probability initially increases and then…

Soft Condensed Matter · Physics 2012-12-06 Kehong Zhang , Kaifu Luo

Polymer translocation through a nanopore in a membrane investigated theoretically. Recent experiments on voltage-driven DNA and RNA translocations through a nanopore indicate that the size and geometry of the pore are important factors in…

Statistical Mechanics · Physics 2009-11-07 Elena Slonkina , Anatoly B. Kolomeisky

We present a theoretical description of the dynamics of a semi-flexible polymer being pulled through a nanopore by an external force acting at the pore. Our theory is based on the tensile blob picture of Pincus in which the front of the…

Statistical Mechanics · Physics 2015-09-16 Pui-Man Lam , Yi Zhen

We investigate several scaling properties of a translocating homopolymer through a thin pore driven by an external field present inside the pore only using Langevin Dynamics (LD) simulation in three dimension (3D). Specifically motivated by…

In forced polymer translocation, the average translocation time, $\tau$, scales with respect to pore force, $f$, and polymer length, $N$, as $\tau \sim f^{-1} N^{\beta}$. We demonstrate that an artifact in Metropolis Monte Carlo method…

Biological Physics · Physics 2009-11-13 V. V. Lehtola , R. P. Linna , K. Kaski

We show the presence of both a minimum and clear oscillations in the frequency dependence of the translocation time of a polymer described as a unidimensional Rouse chain driven by a spatially localized oscillating linear potential. The…

Soft Condensed Matter · Physics 2010-09-16 Alessandro Fiasconaro , Juan José Mazo , Fernando Falo

Using Langevin dynamics simulations, we investigate the influence of polymer-pore interactions on the dynamics of biopolymer translocation through nanopores. We find that an attractive interaction can significantly change the translocation…

Soft Condensed Matter · Physics 2008-12-21 Kaifu Luo , Tapio Ala-Nissila , See-Chen Ying , Aniket Bhattacharya

Here using LAMMPS molecular dynamics (MD) software, we simulate polymer translocation in 2 dimensions. We do the simulations for weak and moderate forces and for different pore diameters. Our results show that in both non-equilibrium and…

Computational Physics · Physics 2018-04-26 Mohammadreza Niknam Hamidabad , Rouhollah Haji Abdolvahab

Using analytical techniques and Langevin dynamics simulations, we investigate the dynamics of polymer translocation into a narrow channel of width $R$ embedded in two dimensions, driven by a force proportional to the number of monomers in…

Soft Condensed Matter · Physics 2011-08-26 Kaifu Luo , Ralf Metzler

We suggest a governing equation which describes the process of polymer chain translocation through a narrow pore and reconciles the seemingly contradictory features of such dynamics: (i) a Gaussian probability distribution of the…

Soft Condensed Matter · Physics 2011-02-15 Johan L. A. Dubbeldam , V. G. Rostiashvili , A. Milchev , T. A. Vilgis

The impact of thermal fluctuations on the translocation dynamics of a polymer chain driven through a narrow pore has been investigated theoretically and by means of extensive Molecular-Dynamics (MD) simulation. The theoretical consideration…

Soft Condensed Matter · Physics 2015-06-12 J. L. A. Dubbeldam , V. G. Rostiashvili , A. Milchev , T. A. Vilgis

We present event distributions for the polymer translocation obtained by extensive Langevin dynamics simulations. Such distributions have not been reported previously and they provide new understanding of the stochastic characteristics of…

Soft Condensed Matter · Physics 2012-04-13 R. P. Linna , K. Kaski

We present scaling estimates for characteristic times $\tau_{\rm lin}$ and $\tau_{\rm br}$ of pulling ideal linear and randomly branched polymers of $N$ monomers into a small hole by a force $f$. We show that the absorbtion process develops…

Statistical Mechanics · Physics 2009-11-11 A. Y. Grosberg , S. Nechaev , M. Tamm , O. Vasilyev

We investigate the dynamics of pore-driven polymer translocation by theoretical analysis and molecular dynamics (MD) simulations. Using the tension propagation theory within the constant flux approximation we derive an explicit equation of…

Soft Condensed Matter · Physics 2015-06-23 Jalal Sarabadani , Timo Ikonen , Tapio Ala-Nissila

Translocation of a polymer out of curved surface or membrane is studied via mean first passage time approach. Membrane curvature gives rise to a constraint on polymer conformation, which effectively drives the polymer to the outside of…

Soft Condensed Matter · Physics 2009-10-31 Pyeong Jun Park , Wokyung Sung

Force-driven translocation of a macromolecule through a nanopore is investigated by taking into account the monomer-pore friction as well as the "crowding" of monomers on the {\it trans} - side of the membrane which counterbalance the…

Soft Condensed Matter · Physics 2014-10-06 Johan L. A. Dubbeldam , V. G. Rostiashvili , T. A. Vilgis

The translocation of a polymer through a pore in a membrane separating fluids of different viscosities is studied via several computational approaches. Starting with the polymer halfway, we find that as a viscosity difference across the…

Soft Condensed Matter · Physics 2013-04-17 Hendrick W. de Haan , Gary W. Slater

Monte Carlo (MC) simulations are used to study the dynamics of polymer translocation through a nanopore in the limit where the translocation rate is sufficiently slow that the polymer maintains a state of conformational quasi-equilibrium.…

Soft Condensed Matter · Physics 2015-06-12 James M. Polson , Anthony C. M. McCaffrey

We present results from our simulations of biopolymer translocation in a solvent which explain the main experimental findings. The forced translocation can be described by simple force balance arguments for the relevant range of pore…

Biological Physics · Physics 2009-05-08 V. V. Lehtola , R. P. Linna , K. Kaski