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The stochastic FitzHugh-Nagumo (FHN) model is a two-dimensional nonlinear stochastic differential equation with additive degenerate noise, whose first component, the only one observed, describes the membrane voltage evolution of a single…

Computation · Statistics 2024-10-08 Adeline Samson , Massimiliano Tamborrino , Irene Tubikanec

We study the phenomenological model of ensemble of two FitzHugh-Nagumo neuron-like elements with symmetric excitatory couplings. The main advantage of proposed model is the new approach to model of coupling which is implemented by smooth…

Dynamical Systems · Mathematics 2018-12-05 Alexander G. Korotkov , Alexey O. Kazakov , Tatiana A. Levanova , Grigory V. Osipov

The three-dimensional (3D) Fitzhugh-Nagumo neuron model with inertia was shown to exhibit a chaotic mixed-mode dynamics composed of large-amplitude spikes separated by an irregular number of small-amplitude chaotic oscillations. In contrast…

Adaptation and Self-Organizing Systems · Physics 2023-01-25 Marzena Ciszak , Salvador Balle , Oreste Piro , Francesco Marino

In this work, we investigate the spike-adding mechanism in a class of three-dimensional fast-slow systems with three distinct timescales, inspired by the FitzHugh-Nagumo (FHN) model driven by periodic input. First, we numerically generate a…

Dynamical Systems · Mathematics 2025-05-28 Pake Melland , Rodica Curtu , Zahra Aminzare

In this paper, we derive the minimum-energy periodic control that entrains an ensemble of structurally similar neural oscillators to a desired frequency. The state space representation of a nominal oscillator is reduced to a phase model by…

Neurons and Cognition · Quantitative Biology 2012-02-24 Anatoly Zlotnik , Jr-Shin Li

In this paper, the transport phenomena of synaptic electric impulses are considered. The FitzHugh--Nagumo and FitzHugh--Rinzel models appear mathematically appropriate for evaluating these scientific issues. Moreover, applications of such…

Mathematical Physics · Physics 2023-06-13 Monica De Angelis

Temporal Interference Stimulation (TIS) is a non-invasive neuromodulation technique in which two high-frequency sinusoidal currents with slightly different frequencies generate a low-frequency envelope that can activate deep neural…

Dynamical Systems · Mathematics 2026-05-19 Esteban Paduro , Antoine Chaillet , Mario Sigalotti

We establish sharp nonlinear stability results for fronts that describe the creation of a periodic pattern through the invasion of an unstable state. The fronts we consider are critical, in the sense that they are expected to mediate…

Analysis of PDEs · Mathematics 2026-03-26 Montie Avery , Paul Carter , Björn de Rijk , Arnd Scheel

Excitable membranes are an important type of nonlinear dynamical system and their study can be used to provide a connection between physical and biological circuits. We discuss two models of excitable membranes important in cardiac and…

Biological Physics · Physics 2012-12-18 Jarrett L. Lancaster , Esther M. Leise , Edward H. Hellen

We consider the existence and first order conditions of optimality for a stochastic optimal control problem inspired by the celebrated FitzHugh-Nagumo model, with nonlinear diffusion term, perturbed by a linear multiplicative Brownian-type…

Optimization and Control · Mathematics 2019-12-03 Francesco Cordoni , Luca Di Persio

Human hearing range significantly surpasses the typical neuronal spiking frequency. Yet, neurons with their modest frequency range not only efficiently receive and process multiple orders higher frequency signals, but also demonstrate…

Neurons and Cognition · Quantitative Biology 2024-08-09 Mariia Sorokina

The Fitzhugh-Nagumo neuronal model is used to explore the influence of the electric field on thermosensitive neurons' dynamics. This study investigates how the electric field affects polarization modulation in cell media induced by changes…

Chaotic Dynamics · Physics 2025-02-13 Ediline L. F. Nguessap , Fernando F. Ferreira , Antonio C. Roque

In this article, we are interested in the behavior of a fully connected network of $N$ neurons, where $N$ tends to infinity. We assume that the neurons follow the stochastic FitzHugh-Nagumo model, whose specificity is the non-linearity with…

Probability · Mathematics 2024-02-14 Laetitia Colombani , Pierre Le Bris

Predicting how the brain can be driven to specific states by means of internal or external control requires a fundamental understanding of the relationship between neural connectivity and activity. Network control theory is a powerful tool…

Neurons and Cognition · Quantitative Biology 2019-08-12 Teresa M. Karrer , Jason Z. Kim , Jennifer Stiso , Ari E. Kahn , Fabio Pasqualetti , Ute Habel , Danielle S. Bassett

We consider a spatially extended mean-field model of a FitzHugh-Nagumo neural network, with a rescaled interaction kernel. Our main purpose is to prove that its asymptotic limit in the regime of strong local interactions converges toward a…

Analysis of PDEs · Mathematics 2020-03-17 Joachim Crevat

Propagation of pulses in myelinated fibers may be described by appropriate solutions of spatially discrete FitzHugh-Nagumo systems. In these systems, propagation failure may occur if either the coupling between nodes is not strong enough or…

Soft Condensed Matter · Physics 2009-03-08 A. Carpio , L. L. Bonilla

We analyze the dynamics of a network of electrically coupled, modified FitzHugh-Nagumo (FHN) oscillators. The network building-block architecture is a bidimensional squared array shaped as a torus, with unidirectional nearest neighbor…

Dynamical Systems · Mathematics 2015-03-20 Adrian C. Murza

High penetration of renewable energy sources intensifies frequency fluctuations in multi-area power systems, challenging both stability and operational safety. This paper proposes a novel distributed frequency control method that ensures…

Systems and Control · Electrical Eng. & Systems 2025-09-10 Xiemin Mo , Tao Liu

This paper studies the phenomenon of conduction block in model neurons using high-frequency biphasic stimulation (HFBS). The focus is investigating the triggering of undesired onset action potentials when the HFBS is turned on. The approach…

Neurons and Cognition · Quantitative Biology 2025-12-29 Eduardo Cerpa , Nathaly Corrales , Matías Courdurier , Leonel E. Medina , Esteban Paduro

Models of pulse formation in nerve conduction have provided manifold insight not only into neuronal dynamics but also the non-linear dynamics of pulse formation in general. Recent observation of neuronal electro-chemical pulses also driving…

Pattern Formation and Solitons · Physics 2023-06-07 Adrian Misselwitz , Suzanne Lafon , Jean-Daniel Julien , Karen Alim