Predicting the Drug Release Kinetics of Matrix Tablets
Abstract
In this paper we develop two mathematical models to predict the release kinetics of a water soluble drug from a polymer/excipient matrix tablet. The first of our models consists of a random walk on a weighted graph, where the vertices of the graph represent particles of drug, excipient and polymer, respectively. The graph itself is the contact graph of a multidisperse random sphere packing. The second model describes the dissolution and the subsequent diffusion of the active drug out of a porous matrix using a system of partial differential equations. The predictions of both models show good qualitative agreement with experimental release curves. The models will provide tools for designing better controlled release devices.
Cite
@article{arxiv.0810.5323,
title = {Predicting the Drug Release Kinetics of Matrix Tablets},
author = {Boris Baeumer and Lipika Chatterjee and Peter Hinow and Thomas Rades and Ami Radunskaya and Ian Tucker},
journal= {arXiv preprint arXiv:0810.5323},
year = {2009}
}
Comments
17 pages, 7 figures; Elaborated at the first Workshop on the Application of Mathematics to Problems in Biomedicine, December 17-19, 2007 at the University of Otago in Dunedin, New Zealand