Iontophoretic transdermal drug delivery: a multi-layered approach
Tissues and Organs
2017-05-31 v2 Numerical Analysis
Abstract
We present a multi-layer mathematical model to describe the the transdermal drug release from an iontophoretic system. The Nernst-Planck equation describe the basic convection-diffusion process, with the electric potential obtained by Laplace equation. These equations are complemented with suitable interface and boundary conditions in a multi-domain. The stability of the mathematical problem is discussed in different scenarios and a finite-difference method is used to solve the coupled system. Numerical experiments are included to illustrate the drug dynamics under different conditions.
Keywords
Cite
@article{arxiv.1601.03074,
title = {Iontophoretic transdermal drug delivery: a multi-layered approach},
author = {Giuseppe Pontrelli and Marco Lauricella and Jose' A. Ferreira and Goncalo Pena},
journal= {arXiv preprint arXiv:1601.03074},
year = {2017}
}
Comments
In Mathematical Medicine and Biology, online, 2016