Modelling drug delivery from multiple emulsions
Abstract
We present a mechanistic model of drug release from a multiple emulsion into an external surrounding fluid. We consider a single multi-layer droplet where the drug kinetics are described by a pure diffusive process through different liquid shells. The multi-layer problem is described by a system of diffusion equations coupled via interlayer conditions imposing continuity of drug concentration and flux. Mass resistance is imposed at the outer boundary through the application of a surfactant at the external surface of the droplet. The two-dimensional problem is solved numerically by finite volume discretization. Concentration profiles and drug release curves are presented for three typical round-shaped (circle, ellipse and bullet) droplets and the dependency of the solution on the mass transfer coefficient at the surface analyzed. The main result shows a reduced release time for an increased elongation of the droplets.
Cite
@article{arxiv.2004.05921,
title = {Modelling drug delivery from multiple emulsions},
author = {G. Pontrelli and E. J. Carr and A. Tiribocchi and S. Succi},
journal= {arXiv preprint arXiv:2004.05921},
year = {2020}
}