Related papers: Predicting the Drug Release Kinetics of Matrix Tab…
Matrix tablets are drug delivery devices designed to release a drug in a controlled manner over an extended period of time. We develop a cellular automaton (CA) model for the dissolution and release of a water-soluble drug and excipient…
Local drug delivery has received much recognition in recent years, yet it is still unpredictable how drug efficacy depends on physicochemical properties and delivery kinetics. The purpose of the current study is to provide a useful…
We propose a mathematical model for computing drug release from multi-layer capsules. The diffusion problem in such heterogeneous layer-by-layer composite medium is described by a system of coupled partial differential equations, which we…
We present a mechanistic model of drug release from a multiple emulsion into an external surrounding fluid. We consider a single multi-layer droplet where the drug kinetics are described by a pure diffusive process through different liquid…
A key step in the development of a new drug is the design of drug-excipient complexes that lead to an optimal drug release kinetics. Computational chemistry, specifically enhanced sampling molecular dynamics methods, can play a key role in…
In this work we develop and investigate mathematical and computational models that describe drug delivery from a contact lens during wear. Our models are designed to predict the dynamics of drug release from the contact lens and subsequent…
A lattice gas model is proposed for investigating the release of drug molecules on devices with semi-permeable, porous membranes in two and three dimensions. The kinetic of this model was obtained through the analytical solution of the…
Predicting the release performance of a drug delivery device is an important challenge in pharmaceutics and biomedical science. In this paper, we consider a multi-layer diffusion model of drug release from a composite spherical microcapsule…
Drug delivery systems represent a promising strategy to treat cancer and to overcome the side effects of chemotherapy. In particular, polymeric nanocontainers have attracted major interest because of their structural and morphological…
Releasing capsules are widely employed in biomedical applications as smart carriers of therapeutic agents, including drugs and bioactive compounds. Such delivery vehicles typically consist of a loaded core, enclosed by one or multiple…
We present a multi-layer mathematical model to describe the the transdermal drug release from an iontophoretic system. The Nernst-Planck equation describe the basic convection-diffusion process, with the electric potential obtained by…
One of the promising frontiers of bioengineering is the controlled release of a therapeuticdrug from a vehicle across the skin (transdermal drug delivery). In order to study the complete process, a two-phase mathematical model describing…
In this study, polyurethane-films loaded diclofenac were used to analyze the drug release kinetics and mechanisms. For this purpose, the experimental procedures were developed under static and dynamic conditions with different initial drug…
Advances in material design has led to the rapid development of novel materials with increasing complexity and functions in bioengineering. In particular, functionally graded materials (FGMs) offer important advantages in various fields of…
In this paper we investigate the extent to which variable porosity drug-eluting coatings can provide better control over drug release than coatings where the porosity is constant throughout. In particular, we aim to establish the potential…
A computational model is proposed to investigate drug delivery systems in which erosion and diffusion mechanisms are participating in the drug release process. Our approach allowed us to analytically estimate the crossover point between…
We study the diffusion process through an ideal polymer network, using numerical methods. Polymers are modeled by random walks on the bonds of a two-dimensional square lattice. Molecules occupy the lattice cells and may jump to the…
Drug-loaded hydrogels provide a means to deliver pharmaceutical agents to specific sites within the body at a controlled rate. The aim of this paper is to understand how controlled drug release can be achieved by tuning the initial…
Molecular communications is a promising framework for the design of controlled-release drug delivery systems. Under this framework, drug carriers, diseased cells, and the channel are modeled as transmitters, absorbing receivers, and…
We investigate diffusion of a peptide drug through Graphene Oxide (GO) membranes that are modeled as a porous layered laminate constructed from aligned flakes of GO. Our experiments using a peptide drug show a tunable non-linear dependence…