English

Event-Triggered Control of Neuron Growth with Actuation at Soma

Optimization and Control 2024-03-19 v2

Abstract

We introduce a dynamic event-triggering mechanism for regulating the axonal growth of a neuron. We apply boundary actuation at the soma (the part of a neuron that contains the nucleus) and regulate the dynamics of tubulin concentration and axon length. The control law is formulated by applying a Zero-Order Hold (ZOH) to a continuous-time controller which guides the axon to reach the desired length. The proposed dynamic event-triggering mechanism determines the specific time instants at which control inputs are sampled from the continuous-time control law. We establish the existence of a minimum dwell-time between two triggering times that ensures avoidance of Zeno behavior. Through employing the Lyapunov analysis with PDE backstepping, we prove the local stability of the closed-loop system in L2L_2-norm, initially for the target system, and subsequently for the original system. The effectiveness of the proposed method is showcased through numerical simulations.

Keywords

Cite

@article{arxiv.2310.00131,
  title  = {Event-Triggered Control of Neuron Growth with Actuation at Soma},
  author = {Cenk Demir and Shumon Koga and Miroslav Krstic},
  journal= {arXiv preprint arXiv:2310.00131},
  year   = {2024}
}

Comments

Accepted to American Control Conference 2024