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This article reviews deep learning applications in biomedical optics with a particular emphasis on image formation. The review is organized by imaging domains within biomedical optics and includes microscopy, fluorescence lifetime imaging,…

Spectral imaging enables spatially-resolved identification of materials in remote sensing, biomedicine, and astronomy. However, acquisition times require balancing spectral and spatial resolution with signal-to-noise. Hyperspectral imaging…

计算机视觉与模式识别 · 计算机科学 2020-03-17 Nguyen Tran , Rupali Mankar , David Mayerich , Zhu Han

Quantum-optical coherence tomography (QOCT) is an optical sectioning modality based on the quantum interference of photon pairs, obtained from a spontaneous parametric downconversion (SPDC) source. The promise of QOCT derives from two…

We report a proof-of-concept demonstration of a tunable infrared (IR) optical coherence tomography (OCT) technique with detection of only visible range photons. Our method is based on the nonclassical interference of frequency correlated…

Nonlinear optical microscopy allows rapid high-resolution microscopy with image contrast generated from intrinsic properties of the sample. Established modalities such as multiphoton excited fluorescence and second/third-harmonic generation…

We propose a chiral imaging modality based on optical chirality engineering, fluorescence-detected circular dichroism and structured illumination microscopy. In this method, the optical chirality of the illumination is structured and the…

We demonstrate a new scheme of infrared spectroscopy with visible light sources and detectors. The technique relies on the nonlinear interference of correlated photons, produced via spontaneous parametric down conversion in a nonlinear…

Medical image fusion is the process of registering and combining multiple images from single or multiple imaging modalities to improve the imaging quality and reduce randomness and redundancy in order to increase the clinical applicability…

计算机视觉与模式识别 · 计算机科学 2014-01-03 A. P. James , B. V. Dasarathy

Super-resolution optical microscopy is a rapidly evolving scientific field dedicated to imaging sub-wavelength sized objects, leaving its mark in multiple branches of biology and technology. While several super-resolution optical microscopy…

Currently, a large number of stored tissue samples are unavailable for spectroscopic study without the time consuming and destructive process of paraffin removal. Instead, a structurally sensitive technique, sum frequency generation, and a…

医学物理 · 物理学 2023-10-03 Bryan Semon , Michael Jaffe , Haifeng Wang , Lauren Priddy , Gombojav Ariunbold

Medical imaging informatics is a rapidly growing field that combines the principles of medical imaging and informatics to improve the acquisition, management, and interpretation of medical images. This chapter introduces the basic concepts…

图像与视频处理 · 电气工程与系统科学 2023-06-21 Md. Zihad Bin Jahangir , Ruksat Hossain , Riadul Islam , MD Abdullah Al Nasim , Md. Mahim Anjum Haque , Md Jahangir Alam , Sajedul Talukder

Using optical speckle scanning microscopy [1], we demonstrate that clear images of multiple cells can be obtained through biological scattering tissue, with subcellular resolution and good image quality, as long as the size of the imaging…

光学 · 物理学 2023-07-19 Xin Yang , Ye Pu , Demetri Psaltis

We describe a scheme into which a camera is turned into an efficient tunable frequency filter of a few Hertz bandwidth in an off-axis, heterodyne optical mixing configuration, enabling to perform parallel, high-resolution coherent spectral…

光学 · 物理学 2009-09-01 Michael Atlan , Michel Gross

We present a new interferometric imaging approach that allows for multiple-depth imaging in a single acquisition, using off-axis low-coherence holographic multiplexing. This technique enables sectioned imaging of multiple slices within a…

光学 · 物理学 2019-03-29 Lauren Wolbromsky , Nir A. Turko , Natan T. Shaked

Vibrational spectroscopy, comprised of infrared absorption and Raman scattering spectroscopy, is widely used for label-free optical sensing and imaging in various scientific and industrial fields. The group theory states that the two…

化学物理 · 物理学 2019-10-09 Kazuki Hashimoto , Venkata Ramaiah Badarla , Akira Kawai , Takuro Ideguchi

Light passing through scattering media will be strongly scattered and diffused into complex speckle pattern, which contains almost all the spatial information and spectral information of the objects. Although various methods have been…

光学 · 物理学 2019-02-04 Lei Zhu , Jietao Liu , Lei Feng , Chengfei Guo , Tengfei Wu , Xiaopeng Shao

While scattered light conveys most of the information we perceive, scattering may also distort that information before it reaches our detectors. The problem is acute in many applications, such as in high-resolution microscopy of biological…

This article proposes a generic framework to process jointly the spatial and spectral information of hyperspectral images. First, sub-images are extracted. Then each of these sub-images follows two parallel workflows, one dedicated to the…

Interferometric scattering microscopy is a powerful technique that enables various applications, such as mass photometry and particle tracking. Here we present a numerical toolbox to simulate images obtained in interferometric scattering,…

Optical coherence tomography (OCT) is a high-resolution three-dimensional imaging technique that enables non-destructive measurements of surface and subsurface microstructures. Recent developments of OCT operating in the mid-infrared (MIR)…

光学 · 物理学 2020-07-15 Ivan Zorin , Rong Su , Bettina Heise , Bernhard Lendl , Markus Brandstetter