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Reliable spike detection and sorting, the process of assigning each detected spike to its originating neuron, is an essential step in the analysis of extracellular electrical recordings from neurons. The volume and complexity of the data…

神经元与认知 · 定量生物学 2018-09-05 Matthias H. Hennig , Cole Hurwitz , Martino Sorbaro

Spikes in the membrane electrical potentials of neurons play a major role in the functioning of nervous systems of animals. Obtaining the spikes from different neurons has been a challenging problem for decades. Several schemes have been…

定量方法 · 定量生物学 2016-02-11 Anupam Mitra , Anagh Pathak , Kaushik Majumdar

Extracellular recordings with multi-electrode arrays is one of the basic tools of contemporary neuroscience. These recordings are mostly used to monitor the activities, understood as sequences of emitted action potentials, of many…

计算工程、金融与科学 · 计算机科学 2014-12-22 Christophe Pouzat , Georgios Is. Detorakis

Spike sorting refers to the problem of assigning action potentials observed in extra-cellular recordings of neural activity to the neuron(s) from which they originate. We cast this problem as one of learning a convolutional dictionary from…

统计方法学 · 统计学 2018-06-07 Andrew H. Song , Francisco Flores , Demba Ba

Developing electrophysiological recordings of brain neuronal activity and their analysis provide a basis for exploring the structure of brain function and nervous system investigation. The recorded signals are typically a combination of…

神经元与认知 · 定量生物学 2019-11-01 Sahar Hojjatinia , Constantino M. Lagoa

Spike sorting is a fundamental preprocessing step for many neuroscience studies which rely on the analysis of spike trains. In this paper, we present two unsupervised spike sorting algorithms based on discriminative subspace learning. The…

计算机视觉与模式识别 · 计算机科学 2014-08-25 Mohammad Reza Keshtkaran , Zhi Yang

One step in the conventional analysis of extracellularly recorded neuronal data is spike sorting, which separates electrical signal into action potentials from different neurons. Because spike sorting involves human judgment, it can be…

神经元与认知 · 定量生物学 2007-05-23 Artur Luczak , Nandakumar S. Narayanan

The advent of large-scale and high-density extracellular recording devices allows simultaneous recording from thousands of neurons. However, the complexity and size of the data makes it mandatory to develop robust algorithms for fully…

神经元与认知 · 定量生物学 2019-12-03 Gerrit Hilgen

An important prerequisite for the analysis of spike synchrony in extracellular recordings is the extraction of single unit activity from the recorded multi unit signal. To identify single units (SUs), potential spikes are detected and…

神经元与认知 · 定量生物学 2018-11-01 Jeyathevy Sukiban , Nicole Voges , Till A. Dembek , Robin Pauli , Michael Denker , Immo Weber , Lars Timmermann , Sonja Grün

Spikes are the currency in central nervous systems for information transmission and processing. They are also believed to play an essential role in low-power consumption of the biological systems, whose efficiency attracts increasing…

神经与进化计算 · 计算机科学 2020-05-05 Qiang Yu , Shenglan Li , Huajin Tang , Longbiao Wang , Jianwu Dang , Kay Chen Tan

Spike-sorting techniques attempt to classify a series of noisy electrical waveforms according to the identity of the neurons that generated them. Existing techniques perform this classification ignoring several properties of actual neurons…

定量方法 · 定量生物学 2007-05-23 Christophe Pouzat

Objective: Spike sorting is a fundamental step in analysing extracellular recordings, enabling the isolation of single-neuron activity. However, it remains a challenging problem because extracellular traces mix overlapping spikes from…

信号处理 · 电气工程与系统科学 2025-06-12 Vasileios Georgiadis , Panagiotis C. Petrantonakis

Human brain neuron activities are incredibly significant nowadays. Neuronal behavior is assessed by analyzing signal data such as electroencephalography (EEG), which can offer scientists valuable information about diseases and…

Spike sorting is a fundamental preprocessing step in neuroscience that is central to access simultaneous but distinct neuronal activities and therefore to better understand the animal or even human brain. But numerical complexity limits…

机器学习 · 统计学 2019-07-01 Laurent Dragoni , Rémi Flamary , Karim Lounici , Patricia Reynaud-Bouret

To date, it is still impossible to sample the entire mammalian brain with single-neuron precision. This forces one to either use spikes (focusing on few neurons) or to use coarse-sampled activity (averaging over many neurons, e.g. LFP).…

神经元与认知 · 定量生物学 2022-12-12 Joao Pinheiro Neto , Franz Paul Spitzner , Viola Priesemann

We address the problem of finding patterns from multi-neuronal spike trains that give us insights into the multi-neuronal codes used in the brain and help us design better brain computer interfaces. We focus on the synchronous firings of…

神经与进化计算 · 计算机科学 2010-06-09 Raajay Viswanathan , P. S. Sastry , K. P. Unnikrishnan

To understand how neural networks process information, it is important to investigate how neural network dynamics varies with respect to different stimuli. One challenging task is to design efficient statistical approaches to analyze…

神经元与认知 · 定量生物学 2018-11-30 Zhi-Qin John Xu , Douglas Zhou , David Cai

In the last decade, there have been major advances in clusterless decoding algorithms for neural data analysis. These algorithms use the theory of marked point processes to describe the joint activity of many neurons simultaneously, without…

神经元与认知 · 定量生物学 2025-12-09 Azar Ghahari , Uri T. Eden

Spike sorting is an essential process in neural recording, which identifies and separates electrical signals from individual neurons recorded by electrodes in the brain, enabling researchers to study how specific neurons communicate and…

神经元与认知 · 定量生物学 2025-12-23 Yimu Zhang , Dongqi Han , Yansen Wang , Zhenning Lv , Yu Gu , Dongsheng Li

Understanding the function of complex cortical circuits requires the simultaneous recording of action potentials from many neurons in awake and behaving animals. Practically, this can be achieved by extracellularly recording from multiple…

定量方法 · 定量生物学 2008-09-25 Ueli Rutishauser , Erin M. Schuman , Adam N. Mamelak
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