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In order to replicate within their cellular host, many viruses have developed self-assembly strategies for their capsids which are sufficiently robust as to be reconstituted in vitro. Mathematical models for virus self-assembly usually…

亚细胞过程 · 定量生物学 2015-02-03 Johanna E. Baschek , Heinrich C. R. Klein , Ulrich S. Schwarz

We investigate general properties of non-deterministic self-assembly with asymmetric interactions, using a computational model and DNA tile assembly experiments. By contrasting symmetric and asymmetric interactions we show that the latter…

软凝聚态物质 · 物理学 2016-08-24 S. Tesoro , K. Göpfrich , T. Kartanas , U. F. Keyser , S. E. Ahnert

Block copolymer self-assembly is a fundamental process in which incompatible blocks spontaneously form organized microstructures with broad practical applications. Classical understanding is that the domain spacing is limited by the contour…

软凝聚态物质 · 物理学 2022-06-28 Shifeng Nian , Zhouhao Fan , Guillaume Freychet , Mikhail Zhernenkov , Stefanie Redemann , Li-Heng Cai

The molecular self-assembly of various structures such as micelles and vesicles has been the subject of comprehensive studies. Recently, a new approach to design these structures, the frame-guided assembly, has been developed to progress…

化学物理 · 物理学 2022-05-11 Simon Raschke , Andreas Heuer

Motivated by observations of heterogeneous domain structure on the surface of cells, we consider a minimal model to describe the dynamics of phase separation on the surface of a spherical particle. Finite-size effects on the curved particle…

软凝聚态物质 · 物理学 2016-07-13 Matthias C. Bott , Joseph M. Brader

We report on the formation of colloidal complexes resulting from the electrostatic self-assembly of polyelectrolyte-neutral block copolymers and oppositely charged surfactants. The copolymers investigated are asymmetric and characterized by…

软凝聚态物质 · 物理学 2007-05-23 Jean-Francois Berret , Pascal Herve , Isabelle Grillo

Epithelial monolayers are a central building block of complex organisms. Topological defects have emerged as important elements for single cell behavior in flat epithelia. Here we theoretically study such defects in a three-dimensional…

生物物理 · 物理学 2025-02-19 Oliver M. Drozdowski , Ulrich S. Schwarz

After rainfall, pine needles often float on the surface of small puddles. As the water evaporates, they self-assemble into distinct clusters. Motivated by this natural phenomenon, we experimentally investigate the dynamic evolution of…

软凝聚态物质 · 物理学 2026-01-06 Xin Li , Shuchen Zhang , Mark J. Bowick , Duanduan Wan

Proteinaceous shells useful for various biomedical applications exhibit a wide range of anomalous structures that are fundamentally different from icosahedral viral capsids described by the Caspar-Klug paradigmatic model. Exploring the…

软凝聚态物质 · 物理学 2025-10-10 Sergei B. Rochal , Aleksey S. Roshal , Olga V. Konevtsova , Rudolf Podgornik

The inverse problem of designing component interactions to target emergent structure is fundamental to numerous applications in biotechnology, materials science, and statistical physics. Equally important is the inverse problem of designing…

计算物理 · 物理学 2020-11-20 Carl P. Goodrich , Ella M. King , Samuel S. Schoenholz , Ekin D. Cubuk , Michael Brenner

For many viruses assembly and budding occur simultaneously during virion formation. Understanding the mechanisms underlying this process could promote biomedical efforts to block viral propagation and enable use of capsids in nanomaterials…

亚细胞过程 · 定量生物学 2014-03-11 Teresa Ruiz-Herrero , Michael F. Hagan

Polypeptides can self-assemble into hierarchically organized fibrils consisting of a stack of individually folded polypeptides driven together by hydrophobic interaction. Using a coarse grained model, we systematically studied this…

软凝聚态物质 · 物理学 2013-07-31 Ran Ni , Sanne Abeln , Marieke Schor , Martien A. Cohen Stuart , Peter G. Bolhuis

Structural organization and correlations are studied in very large packings of equally sized acrylic spheres, reconstructed in three-dimensions by means of X-ray computed tomography. A novel technique, devised to analyze correlations among…

软凝聚态物质 · 物理学 2007-09-19 Tomaso Aste

Collective behavior of proteins on biomembranes is usually studied within the spontaneous curvature model. Here we consider an alternative phenomenological approach, which accounts consistently for partial ordering of proteins as well as…

软凝聚态物质 · 物理学 2014-09-03 O. V. Manyuhina

The field of complex self-assembly is moving toward the design of multi-particle structures consisting of thousands of distinct building blocks. To exploit the potential benefits of structures with such `addressable complexity,' we need to…

软凝聚态物质 · 物理学 2015-06-02 William M. Jacobs , Aleks Reinhardt , Daan Frenkel

The rapid progress in precisely designing the surface decoration of patchy colloidal particles offers a new, yet unexperienced freedom to create building entities for larger, more complex structures in soft matter systems. However, it is…

软凝聚态物质 · 物理学 2012-06-14 G. Doppelbauer , E. G. Noya , E. Bianchi , G. Kahl

Shape had been intuitively recognized to play a dominant role in determining the global motion patterns of bio-molecular assemblies. However, it is not clear exactly how shape determines the motion patterns. What about the local…

生物大分子 · 定量生物学 2019-02-12 Guang Song

Piezo ion channels underlie many forms of mechanosensation in vertebrates, and have been found to bend the membrane into strongly curved dome shapes. We develop here a methodology describing the self-assembly of lipids and Piezo into…

生物物理 · 物理学 2021-09-22 Mingyuan Ma , Christoph A. Haselwandter

At low temperatures, colloidal particles with short-range attractive and long-range repulsive interactions can form various periodic microphases in bulk.In this paper, we investigate the self-assembly behaviour of colloids with competing…

软凝聚态物质 · 物理学 2023-12-12 Ningyi Li , Junhong Li , Lijingting Qing , Shicheng Ma , Yao Li , Baohui Li

We investigate the self-assembly of amphiphilic nanocubes under rest and shear using molecular dynamics (MD) simulations and kinetic Monte Carlo (KMC) calculations. These particles combine both interaction and shape anisotropy, making them…

软凝聚态物质 · 物理学 2023-05-24 Takahiro Yokoyama , Yusei Kobayashi , Noriyoshi Arai , Arash Nikoubashman