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Clinical natural language processing requires methods that can address domain-specific challenges, such as complex medical terminology and clinical contexts. Recently, large language models (LLMs) have shown promise in this domain. Yet,…

计算与语言 · 计算机科学 2025-01-28 Ran Xu , Hejie Cui , Yue Yu , Xuan Kan , Wenqi Shi , Yuchen Zhuang , Wei Jin , Joyce Ho , Carl Yang

One of the major barriers to using large language models (LLMs) in medicine is the perception they use uninterpretable methods to make clinical decisions that are inherently different from the cognitive processes of clinicians. In this…

计算与语言 · 计算机科学 2023-08-15 Thomas Savage , Ashwin Nayak , Robert Gallo , Ekanath Rangan , Jonathan H Chen

Existing medical RAG systems mainly leverage knowledge from medical knowledge bases, neglecting the crucial role of experiential knowledge derived from similar patient cases -- a key component of human clinical reasoning. To bridge this…

计算与语言 · 计算机科学 2025-05-27 Yuxing Lu , Gecheng Fu , Wei Wu , Xukai Zhao , Sin Yee Goi , Jinzhuo Wang

Clinical Decision Support Systems (CDSSs) provide reasoning and inquiry guidance for physicians, yet they face notable challenges, including high maintenance costs and low generalization capability. Recently, Large Language Models (LLMs)…

计算与语言 · 计算机科学 2026-04-24 Yue Guo , Fanfu Wang , Jianwei Lv , Xincheng Shi , Yuchen Li , Youya Wang , Yunsheng Zeng , Yujing Liu , Yunhao Qiao , Gen Li , Junfeng Wang , Bo Yuan

It is becoming increasingly emphasis on the importance of LLM participating in clinical diagnosis decision-making. However, the low specialization refers to that current medical LLMs can not provide specific medical advice, which are more…

计算与语言 · 计算机科学 2023-12-06 Binbin Li , Tianxin Meng , Xiaoming Shi , Jie Zhai , Tong Ruan

Large language models (LLMs) have demonstrated promising performance on medical benchmarks; however, their ability to perform medical calculations, a crucial aspect of clinical decision-making, remains underexplored and poorly evaluated.…

计算与语言 · 计算机科学 2026-02-03 Benlu Wang , Iris Xia , Yifan Zhang , Junda Wang , Feiyun Ouyang , Shuo Han , Arman Cohan , Hong Yu , Zonghai Yao

Clinical diagnosis requires answers that are accurate, verifiable, and explicitly grounded in official guidelines. While large language models excel at natural language processing, their tendency to hallucinate undermines their utility in…

人工智能 · 计算机科学 2026-05-29 Navapat Nananukul , Mayank Kejriwal

Doctors and patients alike increasingly use Large Language Models (LLMs) to diagnose clinical cases. However, unlike domains such as math or coding, where correctness can be objectively defined by the final answer, medical diagnosis…

Large language models have shown promise in clinical decision making, but current approaches struggle to localize and correct errors at specific steps of the reasoning process. This limitation is critical in medicine, where identifying and…

Matching patients to clinical trials demands a systematic and reasoned interpretation of documents which require significant expert-level background knowledge, over a complex set of well-defined eligibility criteria. Moreover, this…

计算与语言 · 计算机科学 2024-10-01 Mael Jullien , Alex Bogatu , Harriet Unsworth , Andre Freitas

Clinical guidance systems have been widely adopted to help medical staffs to avoid preventable medical errors such as delay in diagnosis, treatment or untended deviations from best practice guidelines. However, because patient condition…

计算机与社会 · 计算机科学 2016-10-24 Maryam Rahmaniheris , Yu Jiang , Lui Sha

The ability of large language models (LLMs) to follow natural language instructions with human-level fluency suggests many opportunities in healthcare to reduce administrative burden and improve quality of care. However, evaluating LLMs on…

Physicians considering clinical trials for their patients are met with the laborious process of checking many text based eligibility criteria. Large Language Models (LLMs) have shown to perform well for clinical information extraction and…

机器学习 · 计算机科学 2023-06-30 Danny M. den Hamer , Perry Schoor , Tobias B. Polak , Daniel Kapitan

Despite the growing use of Electronic Health Records (EHR) for AI-assisted diagnosis prediction, most data-driven models struggle to incorporate clinically meaningful medical knowledge. They often rely on limited ontologies, lacking…

机器学习 · 计算机科学 2025-04-17 Pengfei Hu , Chang Lu , Fei Wang , Yue Ning

Machine reasoning has made great progress in recent years owing to large language models (LLMs). In the clinical domain, however, most NLP-driven projects mainly focus on clinical classification or reading comprehension, and under-explore…

Large language models (LLMs) have achieved strong performance on medical exam-style tasks, motivating growing interest in their deployment in real-world clinical settings. However, clinical decision-making is inherently safety-critical,…

计算与语言 · 计算机科学 2026-04-13 Xiaohan Ren , Chenxiao Fan , Wenyin Ma , Hongliang He , Chongming Gao , Xiaoyan Zhao , Fuli Feng

Clinical diagnosis is a complex reasoning process in which clinicians gather evidence, form hypotheses, and test them against alternative explanations. In medical training, this reasoning is explicitly developed through counterfactual…

计算与语言 · 计算机科学 2026-04-24 Zhiwen You , Xi Chen , Aniket Vashishtha , Simo Du , Gabriel Erion-Barner , Hongyuan Mei , Hao Peng , Yue Guo

Machine learning for early prediction in medicine has recently shown breakthrough performance, however, the focus on improving prediction accuracy has led to a neglect of faithful explanations that are required to gain the trust of medical…

计算与语言 · 计算机科学 2025-12-04 Michael Staniek , Artem Sokolov , Stefan Riezler

Large Language Models (LLMs) have shown strong potential in complex medical reasoning yet face diminishing gains under inference scaling laws. While existing studies augment LLMs with various knowledge types, it remains unclear how…

人工智能 · 计算机科学 2026-02-10 Yu Zhao , Hao Guan , Yongcheng Jing , Ying Zhang , Dacheng Tao

The increasing complexity of clinical decision-making, alongside the rapid expansion of electronic health records (EHR), presents both opportunities and challenges for delivering data-informed care. This paper proposes a clinical decision…

人工智能 · 计算机科学 2025-10-03 Leon Garza , Anantaa Kotal , Michael A. Grasso , Emre Umucu