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The Dice similarity coefficient (DSC) is both a widely used metric and loss function for biomedical image segmentation due to its robustness to class imbalance. However, it is well known that the DSC loss is poorly calibrated, resulting in…

图像与视频处理 · 电气工程与系统科学 2022-11-02 Michael Yeung , Leonardo Rundo , Yang Nan , Evis Sala , Carola-Bibiane Schönlieb , Guang Yang

Objectives To develop and validate a deep learning-based diagnostic model incorporating uncertainty estimation so as to facilitate radiologists in the preoperative differentiation of the pathological subtypes of renal cell carcinoma (RCC)…

图像与视频处理 · 电气工程与系统科学 2023-11-14 Ni Yao , Hang Hu , Kaicong Chen , Chen Zhao , Yuan Guo , Boya Li , Jiaofen Nan , Yanting Li , Chuang Han , Fubao Zhu , Weihua Zhou , Li Tian

Accurate early prediction of in-hospital mortality in intensive care units (ICUs) is essential for timely clinical intervention and efficient resource allocation. This study develops and evaluates machine learning models that integrate both…

机器学习 · 计算机科学 2025-10-22 Nursultan Mamatov , Philipp Kellmeyer

Deep metric learning has gained promising improvement in recent years following the success of deep learning. It has been successfully applied to problems in few-shot learning, image retrieval, and open-set classifications. However,…

机器学习 · 计算机科学 2020-06-11 Maryna Karpusha , Sunghee Yun , Istvan Fehervari

Estimates of predictive uncertainty are important for accurate model-based planning and reinforcement learning. However, predictive uncertainties---especially ones derived from modern deep learning systems---can be inaccurate and impose a…

机器学习 · 计算机科学 2019-06-21 Ali Malik , Volodymyr Kuleshov , Jiaming Song , Danny Nemer , Harlan Seymour , Stefano Ermon

Though black-box predictors are state-of-the-art for many complex tasks, they often fail to properly quantify predictive uncertainty and may provide inappropriate predictions for unfamiliar data. Instead, we can learn more reliable models…

机器学习 · 统计学 2021-12-14 Jean Feng , Arjun Sondhi , Jessica Perry , Noah Simon

Reliable uncertainty quantification (UQ) in machine learning (ML) regression tasks is becoming the focus of many studies in materials and chemical science. It is now well understood that average calibration is insufficient, and most studies…

机器学习 · 统计学 2024-01-25 Pascal Pernot

Cardiovascular disease and chronic kidney disease are major complications of diabetes, leading to high morbidity and mortality. Early detection of these conditions is critical, yet traditional diagnostic markers often lack sensitivity in…

其他定量生物学 · 定量生物学 2025-10-20 Syed Ibad Hasnain

Uncertainty in probabilistic classifiers predictions is a key concern when models are used to support human decision making, in broader probabilistic pipelines or when sensitive automatic decisions have to be taken. Studies have shown that…

机器学习 · 计算机科学 2021-09-09 Nicolas Posocco , Antoine Bonnefoy

The regulatory approval and broad clinical deployment of medical AI have been hampered by the perception that deep learning models fail in unpredictable and possibly catastrophic ways. A lack of statistically rigorous uncertainty…

机器学习 · 计算机科学 2022-07-07 Charles Lu , Anastasios N. Angelopoulos , Stuart Pomerantz

Deployed language models must decide not only what to answer but also when not to answer. We present UniCR, a unified framework that turns heterogeneous uncertainty evidence including sequence likelihoods, self-consistency dispersion,…

Uncertainty estimates must be calibrated (i.e., accurate) and sharp (i.e., informative) in order to be useful. This has motivated a variety of methods for recalibration, which use held-out data to turn an uncalibrated model into a…

机器学习 · 计算机科学 2022-07-06 Charles Marx , Shengjia Zhao , Willie Neiswanger , Stefano Ermon

Effective medication management in Parkinson's Disease (PD) is challenging due to heterogeneous disease progression, variable patient response, and medication side effects. While AI models can forecast levodopa equivalent daily dose (LEDD)…

机器学习 · 计算机科学 2026-05-21 Ricardo Diaz-Rincon , Muxuan Liang , Adolfo Ramirez-Zamora , Benjamin Shickel

In principle, deep learning models trained on medical time-series, including wearable photoplethysmography (PPG) sensor data, can provide a means to continuously monitor physiological parameters outside of clinical settings. However, there…

The objective is to assess the extent of variation of data quality and completeness of electronic health records and impact on the robustness of risk predictions of incident cardiovascular disease (CVD) using a risk prediction tool that is…

应用统计 · 统计学 2019-11-21 Yan Li , Matthew Sperrin , Glen P. Martin , Darren M Ashcroft , Tjeerd Pieter van Staa

Chronic kidney disease (CKD) affects millions worldwide and progresses irreversibly through stages culminating in end-stage renal disease (ESRD) and death. Outcome trials in CKD traditionally employ time-to-first-event analyses using the…

统计方法学 · 统计学 2026-01-27 Jiren Sun , Tuo Wang , Yu Du

In a well-calibrated risk prediction model, the average predicted probability is close to the true event rate for any given subgroup. Such models are reliable across heterogeneous populations and satisfy strong notions of algorithmic…

机器学习 · 计算机科学 2023-07-31 Jean Feng , Alexej Gossmann , Romain Pirracchio , Nicholas Petrick , Gene Pennello , Berkman Sahiner

Making calibrated online predictions is a central challenge in modern AI systems. Much of the existing literature focuses on fully adversarial environments where outcomes may be arbitrary, leading to conservative algorithms that can perform…

机器学习 · 计算机科学 2026-05-25 Junyan Liu , Haipeng Luo , Lillian J. Ratliff

The role of uncertainty quantification (UQ) in deep learning has become crucial with growing use of predictive models in high-risk applications. Though a large class of methods exists for measuring deep uncertainties, in practice, the…

机器学习 · 统计学 2019-11-01 Bindya Venkatesh , Jayaraman J. Thiagarajan

Accurate uncertainty quantification is critical for reliable predictive modeling. Existing methods typically address either aleatoric uncertainty due to measurement noise or epistemic uncertainty resulting from limited data, but not both in…

机器学习 · 统计学 2026-03-04 Ilia Azizi , Juraj Bodik , Jakob Heiss , Bin Yu