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Phenotype-driven gene prioritization is a critical process in the diagnosis of rare genetic disorders for identifying and ranking potential disease-causing genes based on observed physical traits or phenotypes. While traditional approaches…

定量方法 · 定量生物学 2024-04-04 Junyoung Kim , Jingye Yang , Kai Wang , Chunhua Weng , Cong Liu

Travel behavior prediction is a core problem in transportation demand management and is traditionally addressed using numerical models calibrated on observed data. With recent advances in large language models (LLMs), new opportunities have…

机器学习 · 计算机科学 2026-03-12 Baichuan Mo , Hanyong Xu , Ruoyun Ma , Jung-Hoon Cho , Dingyi Zhuang , Xiaotong Guo , Jinhua Zhao

Accurate survival prediction in radiotherapy (RT) is critical for optimizing treatment decisions. This study developed and validated the RT-Surv framework, which integrates general-domain, open-source large language models (LLMs) to…

Influenza A viruses (IAVs) evolve antigenically at a pace that requires frequent vaccine updates, yet the haemagglutination inhibition (HI) assays used to quantify antigenicity are labor-intensive and unscalable. As a result, genomic data…

机器学习 · 计算机科学 2025-12-08 Yanhua Xu

This paper introduces an approach that combines the language reasoning capabilities of large language models (LLMs) with the benefits of local training to tackle complex, domain-specific tasks. Specifically, the authors demonstrate their…

计算与语言 · 计算机科学 2023-08-04 V. K. Cody Bumgardner , Aaron Mullen , Sam Armstrong , Caylin Hickey , Jeff Talbert

Recent studies explored integrating state-space search algorithms with Language Models (LM) to perform look-ahead on the token generation process, the ''Tree-of-Thoughts'' (ToT), generated by LMs, thereby improving performance on…

机器学习 · 计算机科学 2026-01-08 Sumedh Pendurkar , Guni Sharon

Accurate forecasts of the number of newly infected people during an epidemic are critical for making effective timely decisions. This paper addresses this challenge using the SIMLR model, which incorporates machine learning (ML) into the…

机器学习 · 计算机科学 2021-06-04 Roberto Vega , Leonardo Flores , Russell Greiner

Large Language Models (LLMs) have achieved significant advances in reasoning tasks. A key approach is tree-based search with verifiers, which expand candidate reasoning paths and use reward models to guide pruning and selection. Although…

Large Language Models (LLMs) are increasingly integrated into critical decision-making pipelines, a trend that raises the demand for robust and automated data analysis. Current approaches to dataset risk analysis are limited to manual…

人工智能 · 计算机科学 2026-05-28 Panteleimon Rodis

Network device and system health management is the foundation of modern network operations and maintenance. Traditional health management methods, relying on expert identification or simple rule-based algorithms, struggle to cope with the…

网络与互联网体系结构 · 计算机科学 2026-03-24 Fengxiao Tang , Xiaonan Wang , Xun Yuan , Linfeng Luo , Ming Zhao , Tianchi Huang , Nei Kato

Large language models (LLMs) have achieved strong performance on medical exam-style tasks, motivating growing interest in their deployment in real-world clinical settings. However, clinical decision-making is inherently safety-critical,…

计算与语言 · 计算机科学 2026-04-13 Xiaohan Ren , Chenxiao Fan , Wenyin Ma , Hongliang He , Chongming Gao , Xiaoyan Zhao , Fuli Feng

This paper presents an innovative exploration of the application potential of large language models (LLM) in addressing the challenging task of automatically generating behavior trees (BTs) for complex tasks. The conventional manual BT…

计算与语言 · 计算机科学 2024-01-17 Fu Li , Xueying Wang , Bin Li , Yunlong Wu , Yanzhen Wang , Xiaodong Yi

Large Language Models (LLMs) have demonstrated potential in predicting mental health outcomes from online text, yet traditional classification methods often lack interpretability and robustness. This study evaluates structured reasoning…

计算与语言 · 计算机科学 2026-01-09 Avinash Patil , Amardeep Kour Gedhu

As the COVID-19 spread over the globe and new variants of COVID-19 keep occurring, reliable real-time forecasts of COVID-19 hospitalizations are critical for public health decision on medical resources allocations such as ICU beds,…

机器学习 · 计算机科学 2022-02-09 Tao Wang , Simin Ma , Soobin Baek , Shihao Yang

Although traditional statistical techniques and machine learning methods have contributed significantly to genetics and, in particular, inherited disease diagnosis, they often struggle with complex, high-dimensional data, a challenge now…

机器学习 · 计算机科学 2025-08-29 Anton Changalidis , Yury Barbitoff , Yulia Nasykhova , Andrey Glotov

The rapid integration of machine learning methodologies in healthcare has ignited innovative strategies for disease prediction, particularly with the vast repositories of Electronic Health Records (EHR) data. This article delves into the…

机器学习 · 计算机科学 2024-08-07 D. Dhinakaran , S. Edwin Raja , M. Thiyagarajan , J. Jeno Jasmine , P. Raghavan

Objective: This study investigates the potential of Large Language Models (LLMs) as an alternative to human expert elicitation for extracting structured causal knowledge and facilitating causal modeling in biometric and healthcare…

人工智能 · 计算机科学 2025-04-15 Olha Shaposhnyk , Daria Zahorska , Svetlana Yanushkevich

Large language Model (LLM)-assisted algorithm discovery is an iterative, black-box optimization process over programs to approximatively solve a target task, where an LLM proposes candidate programs and an external evaluator provides task…

机器学习 · 计算机科学 2026-02-04 Timothee Leleu , Sudeera Gunathilaka , Federico Ghimenti , Surya Ganguli

Recently, the number of off-the-shelf Large Language Models (LLMs) has exploded with many open-source options. This creates a diverse landscape regarding both serving options (e.g., inference on local hardware vs remote LLM APIs) and model…

机器学习 · 计算机科学 2024-12-18 Dimitrios Sikeridis , Dennis Ramdass , Pranay Pareek

The main feature of large-scale multi-objective optimization problems (LSMOP) is to optimize multiple conflicting objectives while considering thousands of decision variables at the same time. An efficient LSMOP algorithm should have the…

神经与进化计算 · 计算机科学 2021-08-10 Haokai Hong , Kai Ye , Min Jiang , Donglin Cao , Kay Chen Tan