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Recent advances in large language models (LLMs) have shown potential in clinical text summarization, but their ability to handle long patient trajectories with multi-modal data spread across time remains underexplored. This study…

Alzheimer's disease (AD) has become a prevalent neurodegenerative disease worldwide. Traditional diagnosis still relies heavily on medical imaging and clinical assessment by physicians, which is often time-consuming and resource-intensive…

Large language models (LLMs) are increasingly being applied to clinical care, a domain where both accuracy and transparent reasoning are critical for safe and trustworthy deployment. Chain-of-thought (CoT) prompting, which elicits…

Chain-of-thought (CoT) reasoning boosts large language models' (LLMs) performance on complex tasks but faces two key limitations: a lack of reliability when solely relying on LLM-generated reasoning chains and lower reasoning performance…

Chain-of-thought (CoT) prompting enables large language models (LLMs) to solve complex reasoning tasks by generating an explanation before the final prediction. Despite it's promising ability, a critical downside of CoT prompting is that…

While Large Language Models (LLMs) have demonstrated potential in healthcare, they often struggle with the complex, non-linear reasoning required for accurate clinical diagnosis. Existing methods typically rely on static, linear mappings…

Large language models (LLMs) offer a generalizable approach for modeling patient trajectories, but suffer from the long and noisy nature of electronic health records (EHR) data in temporal reasoning. To address these challenges, we…

We introduce ColaCare, a framework that enhances Electronic Health Record (EHR) modeling through multi-agent collaboration driven by Large Language Models (LLMs). Our approach seamlessly integrates domain-specific expert models with LLMs to…

Recent advancements in reasoning with large language models (RLLMs), such as OpenAI-O1 and DeepSeek-R1, have demonstrated their impressive capabilities in complex domains like mathematics and coding. A central factor in their success lies…

Recent test-time reasoning methods improve performance by generating more candidate chains or searching over larger reasoning trees, but they typically lack explicit control over when to expand, what to prune, how to repair, and when to…

Large language models (LLMs) have demonstrated exceptional capabilities in planning and tool utilization as autonomous agents, but few have been developed for medical problem-solving. We propose EHRAgent, an LLM agent empowered with a code…

Despite the impressive capabilities of Large Language Models (LLMs), existing Conversational Health Agents (CHAs) remain static and brittle, incapable of adaptive multi-turn reasoning, symptom clarification, or transparent decision-making.…

Drug toxicity remains a major challenge in pharmaceutical development. Recent machine learning models have improved in silico toxicity prediction, but their reliance on annotated data and lack of interpretability limit their applicability.…

Multimodal reasoning is a critical component in the pursuit of artificial intelligence systems that exhibit human-like intelligence, especially when tackling complex tasks. While the chain-of-thought (CoT) technique has gained considerable…

Recent advancements in Chain-of-Thought (CoT) reasoning utilize complex modules but are hampered by high token consumption, limited applicability, and challenges in reproducibility. This paper conducts a critical evaluation of CoT…

Large language models (LLMs) have shown strong performance across natural language reasoning tasks, yet their reasoning processes remain brittle and difficult to interpret. Prompting techniques like Chain-of-Thought (CoT) enhance…

Empathy is critical for effective mental health support, especially when addressing Long Counseling Texts (LCTs). However, existing Large Language Models (LLMs) often generate replies that are semantically fluent but lack the structured…

We explore the extension of chain-of-thought (CoT) prompting to medical reasoning for the task of automatic diagnosis. Motivated by doctors' underlying reasoning process, we present Diagnostic-Reasoning CoT (DR-CoT). Empirical results…

Chain-of-Thought (CoT) and its variants have markedly advanced the reasoning abilities of Large Language Models (LLMs), yet their monolithic and auto-regressive architecture inherently conflates high-level strategic planning with low-level…

Chain-of-Thought (CoT) reasoning has proven effective in enhancing large language models by encouraging step-by-step intermediate reasoning, and recent advances have extended this paradigm to Multimodal Large Language Models (MLLMs). In the…