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The brain-age gap is one of the most investigated risk markers for brain changes across disorders. While the field is progressing towards large-scale models, recently incorporating uncertainty estimates, no model to date provides the…

Bayesian Image-on-Scalar Regression (ISR) provides flexible, uncertainty-aware neuroimaging analysis. However, applying ISR to large-scale datasets such as the UK Biobank is challenging due to intensive computational demands and the need to…

应用统计 · 统计学 2026-02-09 Yuliang Xu , Timothy D. Johnson , Thomas E. Nichols , Jian Kang

Brain MRI underpins a wide range of neuroscientific and clinical applications, yet most learning-based methods remain task-specific and require substantial labeled data. Here we show that a single self-supervised representation can…

Multi-dimensional functional data arises in numerous modern scientific experimental and observational studies. In this paper we focus on longitudinal functional data, a structured form of multidimensional functional data. Operating within a…

统计方法学 · 统计学 2019-09-20 John Shamshoian , Damla Senturk , Shafali Jeste , Donatello Telesca

Longitudinal analysis in medical imaging is crucial to investigate the progressive changes in anatomical structures or disease progression over time. In recent years, a novel class of algorithms has emerged with the goal of learning disease…

We present a probabilistic programmed deep kernel learning approach to personalized, predictive modeling of neurodegenerative diseases. Our analysis considers a spectrum of neural and symbolic machine learning approaches, which we assess…

机器学习 · 计算机科学 2021-01-13 Alexander Lavin

interpretable, and well understood models that are routinely employed even though, as is revealed through prior and posterior predictive checks, these can poorly characterise the spatial heterogeneity in the underlying process of interest.…

Due to its causal semantics, Bayesian networks (BN) have been widely employed to discover the underlying data relationship in exploratory studies, such as brain research. Despite its success in modeling the probability distribution of…

计算机视觉与模式识别 · 计算机科学 2015-06-24 Luping Zhou , Lei Wang , Lingqiao Liu , Philip Ogunbona , Dinggang Shen

Accurate longitudinal analysis of brain MRI is often hindered by evolving lesions, which bias automated neuroimaging pipelines. While deep generative models have shown promise in inpainting these lesions, most existing methods operate…

图像与视频处理 · 电气工程与系统科学 2026-03-09 Zahra Karimaghaloo , Dumitru Fetco , Haz-Edine Assemlal , Hassan Rivaz , Douglas L. Arnold

Bayesian networks are a powerful framework for studying the dependency structure of variables in a complex system. The problem of learning Bayesian networks is tightly associated with the given data type. Ordinal data, such as stages of…

统计方法学 · 统计学 2021-11-15 Xiang Ge Luo , Giusi Moffa , Jack Kuipers

Data privacy and decentralised data collection has become more and more popular in recent years. In order to solve issues with privacy, communication bandwidth and learning from spatio-temporal data, we will propose two efficient models…

机器学习 · 计算机科学 2023-01-19 Timon Sachweh , Daniel Boiar , Thomas Liebig

This paper is concerned with variational and Bayesian approaches to neuro-electromagnetic inverse problems (EEG and MEG). The strong indeterminacy of these problems is tackled by introducing sparsity inducing regularization/priors in a…

信号处理 · 电气工程与系统科学 2023-06-28 Samy Mokhtari , Jean-Michel Badier , Christian G. Bénar , Bruno Torrésani

Background: Brain maturation and aging involve significant microstructural changes, resulting in functional and cognitive alterations. Quantitative MRI (qMRI) can measure this evolution, distinguishing the physiological effects of normal…

In recent years, neuroimaging has undergone a paradigm shift, moving away from the traditional brain mapping approach toward developing integrated, multivariate brain models that can predict categories of mental events. However, large…

应用统计 · 统计学 2022-09-19 Guoqing Wang , Abhirup Datta , Martin A. Lindquist

The number of samples in structural brain MRI studies is often too small to properly train deep learning models. Generative models show promise in addressing this issue by effectively learning the data distribution and generating…

计算机视觉与模式识别 · 计算机科学 2026-03-20 Wei Peng , Tian Xia , Fabio De Sousa Ribeiro , Tomas Bosschieter , Ehsan Adeli , Qingyu Zhao , Ben Glocker , Kilian M. Pohl

Anomaly detection and localization in medical imaging remain critical challenges in healthcare. This paper introduces Spatial-MSMA (Multiscale Score Matching Analysis), a novel unsupervised method for anomaly localization in volumetric…

计算机视觉与模式识别 · 计算机科学 2024-07-19 Ahsan Mahmood , Junier Oliva , Martin Styner

Functional Magnetic Resonance Images acquired during resting-state provide information about the functional organization of the brain through measuring correlations between brain areas. Independent components analysis is the reference…

神经元与认知 · 定量生物学 2014-12-15 Alexandre Abraham , Elvis Dohmatob , Bertrand Thirion , Dimitris Samaras , Gael Varoquaux

Ordinary differential equations (ODEs) can provide mechanistic models of temporally local changes of processes, where parameters are often informed by external knowledge. While ODEs are popular in systems modeling, they are less established…

统计方法学 · 统计学 2025-07-10 Maren Hackenberg , Astrid Pechmann , Clemens Kreutz , Janbernd Kirschner , Harald Binder

Single-subject mapping of resting-state brain functional activity to non-imaging phenotypes is a major goal of neuroimaging. The large majority of learning approaches applied today rely either on static representations or on short-term…

机器学习 · 计算机科学 2022-08-09 Ahmed El-Gazzar , Rajat Mani Thomas , Guido Van Wingen

The spatial composition and cellular heterogeneity of the tumor microenvironment plays a critical role in cancer development and progression. High-definition pathology imaging of tumor biopsies provide a high-resolution view of the spatial…

应用统计 · 统计学 2024-06-25 Nathaniel Osher , Jian Kang , Arvind Rao , Veerabhadran Baladandayuthapani