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Clinical Reasoning on Electronic Health Records (EHRs) is a fundamental yet challenging task in modern healthcare. While in-context learning (ICL) offers a promising inference-time adaptation paradigm for large language models (LLMs) in EHR…

Clinical decision-making requires synthesizing heterogeneous evidence, including patient histories, clinical guidelines, and trajectories of comparable cases. While large language models (LLMs) offer strong reasoning capabilities, they…

人工智能 · 计算机科学 2026-03-03 Shuheng Chen , Namratha Patil , Haonan Pan , Angel Hsing-Chi Hwang , Yao Du , Ruishan Liu , Jieyu Zhao

Despite the growing use of Electronic Health Records (EHR) for AI-assisted diagnosis prediction, most data-driven models struggle to incorporate clinically meaningful medical knowledge. They often rely on limited ontologies, lacking…

机器学习 · 计算机科学 2025-04-17 Pengfei Hu , Chang Lu , Fei Wang , Yue Ning

The vast amount of biomedical information available today presents a significant challenge for investigators seeking to digest, process, and understand these findings effectively. Large Language Models (LLMs) have emerged as powerful tools…

计算与语言 · 计算机科学 2024-07-19 Alexander R. Pelletier , Joseph Ramirez , Irsyad Adam , Simha Sankar , Yu Yan , Ding Wang , Dylan Steinecke , Wei Wang , Peipei Ping

Approximately over 50 million people worldwide suffer from epilepsy. Traditional diagnosis of epilepsy relies on tedious visual screening by highly trained clinicians from lengthy EEG recording that contains the presence of seizure (ictal)…

人工智能 · 计算机科学 2009-04-27 Forrest Sheng Bao , Jue-Ming Gao , Jing Hu , Donald Y. -C. Lie , Yuanlin Zhang , K. J. Oommen

Question answering is a natural language understanding task that involves reasoning over both explicit context, and unstated relevant domain knowledge. Despite the high cost of training, large language models (LLMs) -- the backbone of most…

计算与语言 · 计算机科学 2025-04-24 Laura Cabello , Carmen Martin-Turrero , Uchenna Akujuobi , Anders Søgaard , Carlos Bobed

Epilepsy is a highly prevalent brain condition with many serious complications arising from it. The majority of patients which present to a clinic and undergo electroencephalogram (EEG) monitoring would be unlikely to experience seizures…

信号处理 · 电气工程与系统科学 2023-12-14 Matthew McDougall , Hezam Albaqami , Ghulam Mubashar Hassan , Amitava Datta

Due to the remarkable reasoning ability, Large language models (LLMs) have demonstrated impressive performance in knowledge graph question answering (KGQA) tasks, which find answers to natural language questions over knowledge graphs (KGs).…

计算与语言 · 计算机科学 2025-02-25 Xiao Long , Liansheng Zhuang , Aodi Li , Minghong Yao , Shafei Wang

Increasingly large electronic health records (EHRs) provide an opportunity to algorithmically learn medical knowledge. In one prominent example, a causal health knowledge graph could learn relationships between diseases and symptoms and…

应用统计 · 统计学 2019-10-04 Irene Y. Chen , Monica Agrawal , Steven Horng , David Sontag

Diagnosing epilepsy is a problem of crucial importance. So analysing EEG data is of much importance to help this diagnosis. Assembling the Feigenbaum graphs for EEG signals. And calculating their average clustering, average degree, and…

神经元与认知 · 定量生物学 2019-02-08 Gabriel Guarneros B. , Cristian Pérez A. , Andrea Montiel P. , J. F. Rojas

To improve the reliability of Large Language Models (LLMs) in clinical applications, retrieval-augmented generation (RAG) is extensively applied to provide factual medical knowledge. However, beyond general medical knowledge from open-ended…

计算与语言 · 计算机科学 2025-05-29 Justice Ou , Tinglin Huang , Yilun Zhao , Ziyang Yu , Peiqing Lu , Rex Ying

Electroencephalography (EEG) is a complex signal and can require several years of training to be correctly interpreted. Recently, deep learning (DL) has shown great promise in helping make sense of EEG signals due to its capacity to learn…

Neurological disorders pose major global health challenges, driving advances in brain signal analysis. Scalp electroencephalography (EEG) and intracranial EEG (iEEG) are widely used for diagnosis and monitoring. However, dataset…

神经元与认知 · 定量生物学 2025-10-24 Jiahe Li , Xin Chen , Fanqi Shen , Junru Chen , Yuxin Liu , Daoze Zhang , Zhizhang Yuan , Fang Zhao , Meng Li , Yang Yang

Evaluations of large language models (LLMs) primarily emphasize convergent logical reasoning, where success is defined by producing a single correct proof. However, many real-world reasoning problems admit multiple valid derivations,…

人工智能 · 计算机科学 2026-02-25 Yanrui Wu , Lingling Zhang , Xinyu Zhang , Jiayu Chang , Pengyu Li , Xu Jiang , Jingtao Hu , Jun Liu

Large language models (LLMs) are rapidly transforming various domains, including biomedicine and healthcare, and demonstrate remarkable potential from scientific research to new drug discovery. Graph-based retrieval-augmented generation…

定量方法 · 定量生物学 2025-11-14 Guofeng Meng , Li Shen , Qiuyan Zhong , Wei Wang , Haizhou Zhang , Xiaozhen Wang

Recent advancements in Large Language Models (LLMs) have demonstrated significant promise in clinical diagnosis. However, current models struggle to emulate the iterative, diagnostic hypothesis-driven reasoning of real clinical scenarios.…

计算与语言 · 计算机科学 2026-01-06 Qipeng Wang , Rui Sheng , Yafei Li , Huamin Qu , Yushi Sun , Min Zhu

In recent years, accurately and quickly deploying medical large language models (LLMs) has become a trend. Among these, retrieval-augmented generation (RAG) has garnered attention due to rapid deployment and privacy protection. However, the…

计算与语言 · 计算机科学 2025-08-06 Penglei Sun , Yixiang Chen , Xiang Li , Xiaowen Chu

Biomedical knowledge resources often either preserve evidence as unstructured text or compress it into flat triples that omit study design, provenance, and quantitative support. Here we present EvidenceNet, a disease-specific dataset of…

计算工程、金融与科学 · 计算机科学 2026-04-15 Chang Zong , Sicheng Lv , Si-tu Xue , Huilin Zheng , Jian Wan , Lei Zhang

Large Language Models (LLMs) have shown strong potential in complex medical reasoning yet face diminishing gains under inference scaling laws. While existing studies augment LLMs with various knowledge types, it remains unclear how…

人工智能 · 计算机科学 2026-02-10 Yu Zhao , Hao Guan , Yongcheng Jing , Ying Zhang , Dacheng Tao

Large language models (LLMs) have demonstrated remarkable success across a wide range of tasks; however, they still encounter challenges in reasoning tasks that require understanding and inferring relationships between distinct pieces of…

计算与语言 · 计算机科学 2025-01-15 Haoyu Han , Yaochen Xie , Hui Liu , Xianfeng Tang , Sreyashi Nag , William Headden , Hui Liu , Yang Li , Chen Luo , Shuiwang Ji , Qi He , Jiliang Tang