相关论文: MTCurv: Deep learning for direct microtubule curva…

Microtubules are cytoskeletal filaments that play essential roles in many cellular processes and are key therapeutic targets in several diseases. Accurate segmentation of microtubule networks is critical for studying their organization and…

Fluorescence microscopy has become a widely used tool for studying various biological structures of in vivo tissue or cells. However, quantitative analysis of these biological structures remains a challenge due to their complexity which is…

Cancer survival prediction using multi-modal medical imaging presents a critical challenge in oncology, mainly due to the vulnerability of deep learning models to noise and protocol variations across imaging centers. Current approaches…

Fluorescence microscopy is essential to study biological structures and dynamics. However, existing systems suffer from a tradeoff between field-of-view (FOV), resolution, and complexity, and thus cannot fulfill the emerging need of…

Diffusion magnetic resonance imaging (dMRI) is a crucial non-invasive technique for exploring the microstructure of the living human brain. Traditional hand-crafted and model-based tissue microstructure reconstruction methods often require…

Segmentation of medical images is a fundamental task with numerous applications. While MRI, CT, and PET modalities have significantly benefited from deep learning segmentation techniques, more recent modalities, like functional ultrasound…

Despite advances in deep learning, robustness under domain shift remains a major bottleneck in medical imaging settings. Findings on natural images suggest that deep neural models can show a strong textural bias when carrying out image…

We propose a deep learning strategy to estimate the mean curvature of two-dimensional implicit interfaces in the level-set method. Our approach is based on fitting feed-forward neural networks to synthetic data sets constructed from…

Quantification of microscopy time-series of in vitro reconstituted motor driven microtubule (MT) transport in 'gliding assays' is typically performed using computational object tracking tools. However, these are limited to non-intersecting…

Segmenting cytoskeletal filaments in microscopy images is essential for studying their roles in cellular processes. However, this task is highly challenging due to the fine, densely packed, and intertwined nature of these structures.…

We propose a new method of instance-level microtubule (MT) tracking in time-lapse image series using recurrent attention. Our novel deep learning algorithm segments individual MTs at each frame. Segmentation results from successive frames…

Super-resolution fluorescence microscopy, with a resolution beyond the diffraction limit of light, has become an indispensable tool to directly visualize biological structures in living cells at a nanometer-scale resolution. Despite…

Robustness of deep neural networks to input noise remains a critical challenge, as naive noise injection often degrades accuracy on clean (uncorrupted) data. We propose a novel training framework that addresses this trade-off through two…

To have a superior generalization, a deep learning neural network often involves a large size of training sample. With increase of hidden layers in order to increase learning ability, neural network has potential degradation in accuracy.…

Ultrasound Localization Microscopy can resolve the microvascular bed down to a few micrometers. To achieve such performance microbubble contrast agents must perfuse the entire microvascular network. Microbubbles are then located…

Accurate segmentation of tubular structures in medical images, such as vessels and airway trees, is crucial for computer-aided diagnosis, radiotherapy, and surgical planning. However, significant challenges exist in algorithm design when…

Understanding body part geometry is crucial for precise medical diagnostics. Curves effectively describe anatomical structures and are widely used in medical imaging applications related to cardiovascular, respiratory, and skeletal…

The highly non-linear nature of deep neural networks causes them to be susceptible to adversarial examples and have unstable gradients which hinders interpretability. However, existing methods to solve these issues, such as adversarial…

Volumetric imaging by fluorescence microscopy is often limited by anisotropic spatial resolution from inferior axial resolution compared to the lateral resolution. To address this problem, here we present a deep-learning-enabled…

Traditional neuroimage analysis pipelines involve computationally intensive, time-consuming optimization steps, and thus, do not scale well to large cohort studies with thousands or tens of thousands of individuals. In this work we propose…