相关论文: CMGL: Confidence-guided Multi-omics Graph Learning…

Here, we describe one of the first Web-scale hybrid Knowledge Graph (KG)-Large Language Model (LLM), populated with the latest peer-reviewed medical knowledge on colorectal Cancer. It is currently being evaluated to assist with both medical…

Non-small cell lung cancer (NSCLC) is a serious disease and has a high recurrence rate after the surgery. Recently, many machine learning methods have been proposed for recurrence prediction. The methods using gene data have high prediction…

In deepfake detection, the varying degrees of compression employed by social media platforms pose significant challenges for model generalization and reliability. Although existing methods have progressed from single-modal to multimodal…

Large Language Models (LLMs) often suffer from hallucinations, which Retrieval-Augmented Generation (RAG) and GraphRAG mitigate by incorporating external knowledge and knowledge graphs (KGs). However, GraphRAG remains text-centric due to…

Cancer remains one of the most challenging diseases to treat in the medical field. Machine learning has enabled in-depth analysis of rich multi-omics profiles and medical imaging for cancer diagnosis and prognosis. Despite these…

In-context learning (ICL) effectively conditions large language models (LLMs) for molecular tasks, such as property prediction and molecule captioning, by embedding carefully selected demonstration examples into the input prompt. This…

Neuroblastoma (NB), a leading cause of childhood cancer mortality, exhibits significant histopathological variability, necessitating precise subtyping for accurate prognosis and treatment. Traditional diagnostic methods rely on subjective…

With large-scale well-labeled datasets, deep learning has shown significant success in medical image segmentation. However, it is challenging to acquire abundant annotations in clinical practice due to extensive expertise requirements and…

Leveraging multimodal information from Magnetic Resonance Imaging (MRI) plays a vital role in lesion segmentation, especially for brain tumors. However, in clinical practice, multimodal MRI data are often incomplete, making it challenging…

Cancer research is increasingly driven by the integration of diverse data modalities, spanning from genomics and proteomics to imaging and clinical factors. However, extracting actionable insights from these vast and heterogeneous datasets…

The National Comprehensive Cancer Network (NCCN) provides evidence-based guidelines for cancer treatment. Translating complex patient presentations into guideline-compliant treatment recommendations is time-intensive, requires specialized…

High-resolution mapping of cells and tissue structures provides a foundation for developing interpretable machine-learning models for computational pathology. Deep learning algorithms can provide accurate mappings given large numbers of…

Accurately predicting molecular properties is a challenging but essential task in drug discovery. Recently, many mono-modal deep learning methods have been successfully applied to molecular property prediction. However, the inherent…

Kernel methods have been extensively utilized in machine learning for classification and prediction tasks due to their ability to capture complex non-linear data patterns. However, single kernel approaches are inherently limited, as they…

Cancer prognosis is often based on a set of omics covariates and a set of established clinical covariates such as age and tumor stage. Combining these two sets poses challenges. First, dimension difference: clinical covariates should be…

Annotation cost is a bottleneck for collecting massive data in mammography, especially for training deep neural networks. In this paper, we study the use of heterogeneous levels of annotation granularity to improve predictive performances.…

Cancer clinics capture disease data at various scales, from genetic to organ level. Current bioinformatic methods struggle to handle the heterogeneous nature of this data, especially with missing modalities. We propose PARADIGM, a Graph…

Integration and analysis of multi-omics data provide valuable insights for improving cancer subtype classification. However, such data are inherently heterogeneous, high-dimensional, and exhibit complex intra- and inter-modality…

Background: More than 80% of U.S. cancer care is delivered in community settings, where survival remains worse than at academic centers. Clinicians must integrate genomics, staging, radiology, pathology, and changing guidelines, creating…

The early detection of glottic carcinoma is critical for improving patient outcomes, as it enables timely intervention, preserves vocal function, and significantly reduces the risk of tumor progression and metastasis. However, the…