相关论文: In Search of Lost DNA Sequence Pretraining

Self-supervised learning (SSL) is a machine learning approach where the data itself provides supervision, eliminating the need for external labels. The model is forced to learn about the data structure or context by solving a pretext task.…

There are already many DNA large language models, but most of them still follow traditional uses, such as extracting sequence features for classification tasks. More innovative applications of large language models, such as prompt…

Machine learning methods are increasingly employed to address challenges faced by biologists. One area that will greatly benefit from this cross-pollination is the problem of biological sequence design, which has massive potential for…

The pretrain-finetune paradigm has shown outstanding performance on many applications of deep learning, where a model is pre-trained on a upstream large dataset (e.g. ImageNet), and is then fine-tuned to different downstream tasks. Though…

Foundation models have recently gained attention within the field of machine learning thanks to its efficiency in broad data processing. While researchers had attempted to extend this success to time series models, the main challenge is…

Proteins are sequences of amino acids that serve as the basic building blocks of living organisms. Despite rapidly growing databases documenting structural and functional information for various protein sequences, our understanding of…

In this work, we dive deep into the impact of additive noise in pre-training deep networks. While various methods have attempted to use additive noise inspired by the success of latent denoising diffusion models, when used in combination…

Deep Neural Networks (DNNs) are everywhere, frequently performing a fairly complex task that used to be unimaginable for machines to carry out. In doing so, they do a lot of decision making which, depending on the application, may be…

Rapid development of large-scale pre-training has resulted in foundation models that can act as effective feature extractors on a variety of downstream tasks and domains. Motivated by this, we study the efficacy of pre-trained vision models…

Neural network models and deep models are one of the leading and state of the art models in machine learning. Most successful deep neural models are the ones with many layers which highly increases their number of parameters. Training such…

Protein representation learning aims to learn informative protein embeddings capable of addressing crucial biological questions, such as protein function prediction. Although sequence-based transformer models have shown promising results by…

Assisted by the availability of data and high performance computing, deep learning techniques have achieved breakthroughs and surpassed human performance empirically in difficult tasks, including object recognition, speech recognition, and…

DNA has immense potential as an emerging data storage medium. The principle of DNA storage is the conversion and flow of digital information between binary code stream, quaternary base, and actual DNA fragments. This process will inevitably…

Large-scale brain imaging datasets provide unprecedented opportunities for developing domain foundation models through pretraining. However, unlike natural image datasets in computer vision, these neuroimaging data often exhibit high…

Foundation models have made significant strides in understanding the genomic language of DNA sequences. However, previous models typically adopt the tokenization methods designed for natural language, which are unsuitable for DNA sequences…

Recent developments in Natural Language Processing (NLP) demonstrate that large-scale, self-supervised pre-training can be extremely beneficial for downstream tasks. These ideas have been adapted to other domains, including the analysis of…

Deep neural networks (DNNs) are powerful learning machines that have enabled breakthroughs in several domains. In this work, we introduce a new retrospective loss to improve the training of deep neural network models by utilizing the prior…

Weakly-supervised anomaly detection aims at learning an anomaly detector from a limited amount of labeled data and abundant unlabeled data. Recent works build deep neural networks for anomaly detection by discriminatively mapping the normal…

DNA sequencing is revolutionising the field of medicine. DNA sequencers, the machines which perform DNA sequencing, have evolved from the size of a fridge to that of a mobile phone over the last two decades. The cost of sequencing a human…

The self-supervised objective of masking-and-predicting has led to promising performance gains on a variety of downstream tasks. However, while most approaches randomly mask tokens, there is strong intuition that deciding what to mask can…