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An accurate binding affinity prediction between T-cell receptors and epitopes contributes decisively to develop successful immunotherapy strategies. Some state-of-the-art computational methods implement deep learning techniques by…

机器学习 · 计算机科学 2024-01-18 Etienne Goffinet , Raghvendra Mall , Ankita Singh , Rahul Kaushik , Filippo Castiglione

This paper addresses a key limitation in existing counterfactual inference methods for Markov Decision Processes (MDPs). Current approaches assume a specific causal model to make counterfactuals identifiable. However, there are usually many…

人工智能 · 计算机科学 2026-05-25 Jessica Lally , Milad Kazemi , Nicola Paoletti

Estimating treatment effects over time holds significance in various domains, including precision medicine, epidemiology, economy, and marketing. This paper introduces a unique approach to counterfactual regression over time, emphasizing…

机器学习 · 计算机科学 2024-10-30 Mouad El Bouchattaoui , Myriam Tami , Benoit Lepetit , Paul-Henry Cournède

Machine learning models achieve state-of-the-art performance on many supervised learning tasks. However, prior evidence suggests that these models may learn to rely on shortcut biases or spurious correlations (intuitively, correlations that…

机器学习 · 计算机科学 2021-08-31 Sindhu C. M. Gowda , Shalmali Joshi , Haoran Zhang , Marzyeh Ghassemi

Modern artificial intelligence systems require calibrated uncertainty estimates that remain reliable in sequential and non-stationary environments. Online conformal prediction (OCP) addresses this challenge through adaptively updated…

机器学习 · 计算机科学 2026-05-21 Bowen Wang , Matteo Zecchin , Osvaldo Simeone

Conformal prediction (CP) has become a cornerstone of distribution-free uncertainty quantification, conventionally evaluated by its coverage and interval length. This work critically examines the sufficiency of these standard metrics. We…

机器学习 · 统计学 2026-01-30 Yizhou Min , Yizhou Lu , Lanqi Li , Zhen Zhang , Jiaye Teng

Knowledge editing is pivotal for efficiently updating the parametric memory of Large Language Models (LLMs), enabling them to function as evolving agents in dynamic environments. However, mainstream in-parameter knowledge editing approaches…

计算与语言 · 计算机科学 2026-05-21 Xiyu Liu , Zhengxiao Liu , Naibin Gu , Zheng Lin , Weiping Wang

Conformal prediction (CP) is a wrapper around traditional machine learning models, giving coverage guarantees under the sole assumption of exchangeability; in classification problems, for a chosen significance level $\varepsilon$, CP…

机器学习 · 计算机科学 2023-02-23 Javier Abad , Umang Bhatt , Adrian Weller , Giovanni Cherubin

Conformal Prediction (CP) has proven to be an effective post-hoc method for improving the trustworthiness of neural networks by providing prediction sets with finite-sample guarantees. However, under adversarial attacks, classical conformal…

We propose \textbf{Temporal Conformal Prediction (TCP)}, a distribution-free framework for constructing well-calibrated prediction intervals in nonstationary time series. TCP couples a modern quantile forecaster with a rolling…

机器学习 · 统计学 2026-01-26 Agnideep Aich , Ashit Baran Aich , Dipak C. Jain

In text classification tasks, models often rely on spurious correlations for predictions, incorrectly associating irrelevant features with the target labels. This issue limits the robustness and generalization of models, especially when…

机器学习 · 计算机科学 2025-02-04 Yuqing Zhou , Ziwei Zhu

Contrastive Vision-Language Pre-training(CLIP) demonstrates impressive zero-shot capability. The key to improve the adaptation of CLIP to downstream task with few exemplars lies in how to effectively model and transfer the useful knowledge…

计算机视觉与模式识别 · 计算机科学 2024-07-01 Cilin Yan , Haochen Wang , Xiaolong Jiang , Yao Hu , Xu Tang , Guoliang Kang , Efstratios Gavves

The deployment of safe and trustworthy machine learning systems, and particularly complex black box neural networks, in real-world applications requires reliable and certified guarantees on their performance. The conformal prediction…

计算机视觉与模式识别 · 计算机科学 2024-06-14 Paul Melki , Lionel Bombrun , Boubacar Diallo , Jérôme Dias , Jean-Pierre da Costa

Predictive coding (PC) is an influential theory in computational neuroscience, which argues that the cortex forms unsupervised world models by implementing a hierarchical process of prediction error minimization. PC networks (PCNs) are…

神经与进化计算 · 计算机科学 2022-08-05 Beren Millidge , Yuhang Song , Tommaso Salvatori , Thomas Lukasiewicz , Rafal Bogacz

Continual learning (CL) enables deep networks to acquire new knowledge while avoiding catastrophic forgetting. The powerful generalization ability of pre-trained models (PTMs), such as the Contrastive Language-Image Pre-training (CLIP)…

计算机视觉与模式识别 · 计算机科学 2025-12-22 Haodong Lu , Xinyu Zhang , Kristen Moore , Jason Xue , Lina Yao , Anton van den Hengel , Dong Gong

Linear residualization is a common practice for confounding adjustment in machine learning (ML) applications. Recently, causality-aware predictive modeling has been proposed as an alternative causality-inspired approach for adjusting for…

机器学习 · 统计学 2020-11-10 Elias Chaibub Neto

This paper studies the problem of class-incremental learning (CIL), a core setting within continual learning where a model learns a sequence of tasks, each containing a distinct set of classes. Traditional CIL methods, which do not leverage…

机器学习 · 计算机科学 2025-11-19 Saleh Momeni , Changnan Xiao , Bing Liu

Despite attractive theoretical guarantees and practical successes, Predictive Interval (PI) given by Conformal Prediction (CP) may not reflect the uncertainty of a given model. This limitation arises from CP methods using a constant…

机器学习 · 统计学 2023-06-01 Salim I. Amoukou , Nicolas J. B Brunel

Conformal prediction is a valuable tool for quantifying predictive uncertainty of machine learning models. However, its applicability relies on the assumption of data exchangeability, a condition which is often not met in real-world…

机器学习 · 统计学 2024-12-30 Aleksandr Podkopaev , Darren Xu , Kuang-Chih Lee

Conformal prediction (CP) provides finite-sample, distribution-free marginal coverage, but standard conformal regression intervals can be inefficient under heteroscedasticity and skewness. In particular, popular constructions such as…

机器学习 · 统计学 2026-03-03 Xiaoyi Su , Zhixin Zhou , Rui Luo