相关论文: Counterfactual Peptide Editing for Causal TCR--pMH…

Predicting T-cell receptor (TCR)--peptide-MHC (pMHC) binding is central to vaccine design and T-cell therapy, yet deployed models frequently encounter epitopes unseen during training, causing silent overconfidence and unreliable…

Personalized decision making requires the knowledge of potential outcomes under different treatments, and confidence intervals about the potential outcomes further enrich this decision-making process and improve its reliability in…

Notions of counterfactual invariance (CI) have proven essential for predictors that are fair, robust, and generalizable in the real world. We propose graphical criteria that yield a sufficient condition for a predictor to be…

Contrastive Language-Image Pretraining (CLIP) has achieved remarkable success, but its performance can degrade when fine-tuned in out-of-distribution (OOD) scenarios. We model the prediction process using a Structural Causal Model (SCM) and…

Deep neural network based question answering (QA) models are neither robust nor explainable in many cases. For example, a multiple-choice QA model, tested without any input of question, is surprisingly "capable" to predict the most of…

The complex nature of tripartite peptide-MHC-TCR interactions is a critical yet underexplored area in immunogenicity prediction. Traditional studies on TCR-antigen binding have not fully addressed the complex dependencies in triad binding.…

Counterfactual explanations (CFXs) provide human-understandable justifications for model predictions, enabling actionable recourse and enhancing interpretability. To be reliable, CFXs must avoid regions of high predictive uncertainty, where…

Conformal prediction (CP) provides powerful, distribution-free prediction sets, but its guarantees rely on the exchangeability of training and test data, which is often violated in practice due to covariate shifts. While weighted conformal…

Contrasting marginal counterfactual survival curves across treatment arms is an effective and popular approach for inferring the causal effect of an intervention on a right-censored time-to-event outcome. A key challenge to drawing such…

Deep learning models can predict protein properties with unprecedented accuracy but rarely offer mechanistic insight or actionable guidance for engineering improved variants. When a model flags an antibody as unstable, the protein engineer…

Despite large-scale pre-trained language models have achieved striking results for text classificaion, recent work has raised concerns about the challenge of shortcut learning. In general, a keyword is regarded as a shortcut if it creates a…

In counterfactual learning to rank (CLTR) user interactions are used as a source of supervision. Since user interactions come with bias, an important focus of research in this field lies in developing methods to correct for the bias of…

A central challenge in any study of the effects of beliefs on outcomes, such as decisions and behavior, is the risk of omitted variables bias. Omitted variables, frequently unmeasured or even unknown, can induce correlations between beliefs…

Syntactically controlled paraphrase generation requires language models to generate paraphrases for sentences according to specific syntactic structures. Existing fine-tuning methods for this task are costly as all the parameters of the…

Counterfactual explanations for black-box models aim to pr ovide insight into an algorithmic decision to its recipient. For a binary classification problem an individual counterfactual details which features might be changed for the model…

While Conformal Prediction (CP) has proven to be a powerful framework for uncertainty quantification, guaranteeing conditional coverage remains a central challenge. Although finite-sample, distribution-free conditional validity is known to…

We propose a counterfactual approach to train ``causality-aware" predictive models that are able to leverage causal information in static anticausal machine learning tasks (i.e., prediction tasks where the outcome influences the features).…

Predictive coding (PC) is a general theory of cortical function. The local, gradient-based learning rules found in one kind of PC model have recently been shown to closely approximate backpropagation. This finding suggests that this…

Through the use of carefully tailored convolutional neural network architectures, a deep image prior (DIP) can be used to obtain pre-images from latent representation encodings. Though DIP inversion has been known to be superior to…

CLIP-style contrastive pretraining typically curates web-scale image-text pairs using sample-level filtering signals, often based on pair-level alignment. We show that this signal saturates: once coarse mismatches are removed, stricter…