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Next generation online and real-time adaptive radiotherapy workflows require precise particle transport simulations in sub-second times, which is unfeasible with current analytical pencil beam algorithms (PBA) or stochastic Monte Carlo (MC)…

医学物理 · 物理学 2022-02-08 Oscar Pastor-Serrano , Zoltán Perkó

Accurate dose calculation on cone beam computed tomography (CBCT) images is essential for modern proton treatment planning workflows, particularly when accounting for inter-fractional anatomical changes in adaptive treatment scenarios.…

Purpose: Proton therapy provides superior dose conformity compared to photon therapy, but its treatment planning is challenged by sensitivity to anatomical changes, setup/range uncertainties, and computational complexity. This review…

Accurate dose calculation is vitally important for proton therapy. Pencil beam (PB) model-based dose calculation is fast but inaccurate due to the approximation when dealing with inhomogeneities. Monte Carlo (MC) dose calculation is the…

Microbeam radiation therapy (MRT) utilizes coplanar synchrotron radiation beamlets and is a proposed treatment approach for several tumour diagnoses that currently have poor clinical treatment outcomes, such as gliosarcomas. Prescription…

Radiation therapy (RT) requires precise dose delivery over multiple fractions, with CT fundamental for treatment planning due to its electron density information. Repeated CT acquisitions impose radiation exposure and logistical burdens,…

Monte Carlo (MC) simulations provide gold-standard accuracy for carbon ion therapy dose calculations but are computationally intensive. Analytical pencil beam algorithms offer speed but reduced accuracy in heterogeneous tissues. We…

The next great leap toward improving treatment of cancer with radiation will require the combined use of online adaptive and magnetic resonance guided radiation therapy techniques with automatic X-ray beam orientation selection.…

医学物理 · 物理学 2019-08-14 Ryan Neph , Yangsibo Huang , Youming Yang , Ke Sheng

Particle physics simulations are the cornerstone of nuclear engineering applications. Among them radiotherapy (RT) is crucial for society, with 50% of cancer patients receiving radiation treatments. For the most precise targeting of tumors,…

机器学习 · 计算机科学 2021-09-10 Oscar Pastor-Serrano , Zoltán Perkó

Fast dose calculation is critical for online and real time adaptive therapy workflows. While modern physics-based dose algorithms must compromise accuracy to achieve low computation times, deep learning models can potentially perform dose…

医学物理 · 物理学 2023-07-19 Oscar Pastor-Serrano , Peng Dong , Charles Huang , Lei Xing , Zoltán Perkó

In radiotherapy, a trade-off exists between computational workload/speed and dose calculation accuracy. Calculation methods like pencil-beam convolution can be much faster than Monte-Carlo methods, but less accurate. The dose difference,…

医学物理 · 物理学 2020-05-18 Yixun Xing , Ph. D. , You Zhang , Ph. D. , Dan Nguyen , Ph. D. , Mu-Han Lin , Ph. D. , Weiguo Lu , Ph. D. , Steve Jiang , Ph. D

Medical imaging is essential in modern radiotherapy, supporting diagnosis, treatment planning, and monitoring. Synthetic imaging, particularly synthetic computed tomography (sCT), is gaining traction in radiotherapy. The SynthRAD2025…

Purpose: Various dose calculation algorithms are available for radiation therapy for cancer patients. However, these algorithms are faced with the tradeoff between efficiency and accuracy. The fast algorithms are generally less accurate,…

医学物理 · 物理学 2020-07-01 Yixun Xing , Dan Nguyen , Weiguo Lu , Ming Yang , Steve Jiang

Cone beam CT (CBCT) has been widely used for patient setup in image guided radiation therapy (IGRT). Radiation dose from CBCT scans has become a clinical concern. The purposes of this study are 1) to commission a GPU-based Monte Carlo (MC)…

This article examines the critical role of fast Monte Carlo dose calculations in advancing proton therapy techniques, particularly in the context of increasing treatment customization and precision. As adaptive radiotherapy and other…

医学物理 · 物理学 2024-04-24 Jason Holmes , Hongying Feng , Lian Zhang , Michael Fix , Steve B. Jiang , Wei Liu

Cancer is a primary cause of morbidity and mortality worldwide. The radiotherapy plays a more and more important role in cancer treatment. In the radiotherapy, the dose distribution maps in patient need to be calculated and evaluated for…

医学物理 · 物理学 2019-10-18 Zhao Peng , Hongming Shan , Tianyu Liu , Xi Pei , Jieping Zhou , Ge Wang , X. George Xu

We highlight emerging uses of artificial intelligence (AI) in the field of theranostics, focusing on its significant potential to enable routine and reliable personalization of radiopharmaceutical therapies (RPTs). Personalized RPTs require…

Radiotherapy treatment for prostate cancer relies on computed tomography (CT) and/or magnetic resonance imaging (MRI) for segmentation of target volumes and organs at risk (OARs). Manual segmentation of these volumes is regarded as the gold…

Purpose: The presence of respiratory motion during radiation treatment leads to degradation of the expected dose distribution, both for target coverage and healthy-tissue sparing, particularly for techniques like pencil-beam scanning proton…

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