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Automated methods for Alzheimer's disease (AD) classification have the potential for great clinical benefits and may provide insight for combating the disease. Machine learning, and more specifically deep neural networks, have been shown to…

Alzheimer's disease (AD) is an incurable neurodegenerative condition leading to cognitive and functional deterioration. Given the lack of a cure, prompt and precise AD diagnosis is vital, a complex process dependent on multiple factors and…

计算机视觉与模式识别 · 计算机科学 2024-03-26 Guangqian Yang , Kangrui Du , Zhihan Yang , Ye Du , Yongping Zheng , Shujun Wang

Deep learning (DL) has been used in the automatic diagnosis of Mild Cognitive Impairment (MCI) and Alzheimer's Disease (AD) with brain imaging data. However, previous methods have not fully exploited the relation between brain image and…

计算机视觉与模式识别 · 计算机科学 2023-10-24 Luoyao Kang , Haifan Gong , Xiang Wan , Haofeng Li

Brain transcriptomics provides insights into the molecular mechanisms by which the brain coordinates its functions and processes. However, existing multimodal methods for predicting Alzheimer's disease (AD) primarily rely on imaging and…

人工智能 · 计算机科学 2025-04-03 Shan Cong , Zhoujie Fan , Hongwei Liu , Yinghan Zhang , Xin Wang , Haoran Luo , Xiaohui Yao

Mueller matrix imaging provides rich, physically meaningful contrast for biomedical tissue analysis, but supervised learning is hindered by scarce dense annotations and strong domain shifts across specimens and acquisition settings. We…

计算机视觉与模式识别 · 计算机科学 2026-05-25 Adam Tlemsani , Yingdian Li , Maxime Giot , Naim Slim , Christopher J. Peters , Abhijeet Ghosh , Daniel S. Elson

There is a need for automatic diagnosis of certain diseases from medical images that could help medical practitioners for further assessment towards treating the illness. Alzheimers disease is a good example of a disease that is often…

图像与视频处理 · 电气工程与系统科学 2019-01-30 GuruRaj Awate

Although Alzheimer's disease detection via MRIs has advanced significantly thanks to contemporary deep learning models, challenges such as class imbalance, protocol variations, and limited dataset diversity often hinder their generalization…

计算机视觉与模式识别 · 计算机科学 2025-06-02 Zobia Batool , Huseyin Ozkan , Erchan Aptoula

Early and accurate diagnosis of Alzheimer Disease is critical for effective clinical intervention, particularly in distinguishing it from Mild Cognitive Impairment, a prodromal stage marked by subtle structural changes. In this study, we…

图像与视频处理 · 电气工程与系统科学 2025-10-08 Fahad Mostafa , Kannon Hossain , Hafiz Khan

\textbf{Objective:} Alzheimer's disease (AD) is the most prevalent form of dementia worldwide, encompassing a prodromal stage known as Mild Cognitive Impairment (MCI), where patients may either progress to AD or remain stable. The objective…

Accurate and early diagnosis of Alzheimer's disease (AD) is critical for effective intervention and requires integrating complementary information from multimodal neuroimaging data. However, conventional fusion approaches often rely on…

Alzheimer Disease poses a significant challenge, necessitating early detection for effective intervention. MRI is a key neuroimaging tool due to its ease of use and cost effectiveness. This study analyzes machine learning methods for MRI…

神经元与认知 · 定量生物学 2024-08-12 Alwani Liyana Ahmad , Jose Sanchez-Bornot , Roberto C. Sotero , Damien Coyle , Zamzuri Idris , Ibrahima Faye

Positron emission tomography (PET) scans expose patients to radiation, which can be mitigated by reducing the dose, albeit at the cost of diminished quality. This makes low-dose (LD) PET recovery an active research area. Previous studies…

图像与视频处理 · 电气工程与系统科学 2026-03-11 Ghulam Nabi Ahmad Hassan Yar , Himashi Peiris , Victoria Mar , Cameron Dennis Pain , Zhaolin Chen

Accurate brain tumor segmentation is essential for preoperative evaluation and personalized treatment. Multi-modal MRI is widely used due to its ability to capture complementary tumor features across different sequences. However, in…

计算机视觉与模式识别 · 计算机科学 2025-09-19 Shenghao Zhu , Yifei Chen , Weihong Chen , Shuo Jiang , Guanyu Zhou , Yuanhan Wang , Feiwei Qin , Changmiao Wang , Qiyuan Tian

Alzheimer's Disease (AD) is a neurodegenerative disorder that lacks effective treatment options. Anti-amyloid beta (ABeta) antibodies are the leading drug candidates to treat AD, but the results of clinical trials have been disappointing.…

生物大分子 · 定量生物学 2018-04-24 D'Artagnan Greene , Theodora Po , Jennifer Pan , Tanya Tabibian , Ray Luo

Alzheimer's disease is a degenerative brain disease. Being the primary cause of Dementia in adults and progressively destroys brain memory. Though Alzheimer's disease does not have a cure currently, diagnosing it at an earlier stage will…

机器学习 · 计算机科学 2023-02-17 Shrish Pellakur , Nelly Elsayed , Zag ElSayed , Murat Ozer

This paper explores deterioration in Alzheimers Disease using Machine Learning. Subjects were split into two datasets based on baseline diagnosis (Cognitively Normal, Mild Cognitive Impairment), with outcome of deterioration at final visit…

机器学习 · 计算机科学 2023-06-21 Henry Musto , Daniel Stamate , Ida Pu , Daniel Stahl

Currently, the diagnosis of Alzheimer's disease is a complex and error-prone process. Improving this diagnosis could allow earlier detection of the disease and improve the quality of life of patients and their families. For this work, we…

图像与视频处理 · 电气工程与系统科学 2022-10-18 Ángel de la Vega Jiménez

In multi-modal learning, some modalities are more influential than others, and their absence can have a significant impact on classification/segmentation accuracy. Addressing this challenge, we propose a novel approach called Meta-learned…

Differential diagnosis of dementia is challenging due to overlapping symptoms, with structural magnetic resonance imaging (MRI) being the primary method for diagnosis. Despite the clinical value of computer-aided differential diagnosis,…

计算机视觉与模式识别 · 计算机科学 2024-04-10 Yitong Li , Tom Nuno Wolf , Sebastian Pölsterl , Igor Yakushev , Dennis M. Hedderich , Christian Wachinger

Accurate and robust segmentation of lung cancers from CT, even those located close to mediastinum, is needed to more accurately plan and deliver radiotherapy and to measure treatment response. Therefore, we developed a new cross-modality…

图像与视频处理 · 电气工程与系统科学 2021-12-08 Jue Jiang , Andreas Rimner , Joseph O. Deasy , Harini Veeraraghavan