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Large language models (LLMs) are deployed on increasingly complex tasks that require multi-step decision-making. Understanding their algorithmic reasoning abilities is therefore crucial. However, we lack a diagnostic benchmark for…

机器学习 · 计算机科学 2026-02-12 Yu He , Yingxi Li , Colin White , Ellen Vitercik

Connectomics - the mapping of neural connections in an organism's brain - currently requires extraordinary human effort to proofread the data collected from imaging and machine-learning assisted segmentation. With the growing excitement…

神经元与认知 · 定量生物学 2025-11-11 Jeff Brown , Andrew Kirjner , Annika Vivekananthan , Ed Boyden

High-content perturbation experiments allow scientists to probe biomolecular systems at unprecedented resolution, but experimental and analysis costs pose significant barriers to widespread adoption. Machine learning has the potential to…

Recently, there has been a growing interest among large language model (LLM) developers in LLM-based document reading systems, which enable users to upload their own documents and pose questions related to the document contents, going…

计算与语言 · 计算机科学 2024-07-16 Anni Zou , Wenhao Yu , Hongming Zhang , Kaixin Ma , Deng Cai , Zhuosheng Zhang , Hai Zhao , Dong Yu

While large language models (LLMs) excel at many domain-specific tasks, their ability to deeply comprehend and reason about full-length academic papers remains underexplored. Existing benchmarks often fall short of capturing such depth,…

人工智能 · 计算机科学 2026-01-08 Xinbang Dai , Huikang Hu , Yongrui Chen , Jiaqi Li , Rihui Jin , Yuyang Zhang , Xiaoguang Li , Lifeng Shang , Guilin Qi

Large language models (LLMs) have demonstrated their remarkable performance across various language understanding tasks. While emerging benchmarks have been proposed to evaluate LLMs in various domains such as mathematics and computer…

人工智能 · 计算机科学 2024-10-28 Junnan Dong , Zijin Hong , Yuanchen Bei , Feiran Huang , Xinrun Wang , Xiao Huang

Existing Protein Language Models (PLMs) often suffer from limited adaptability to multiple tasks and exhibit poor generalization across diverse biological contexts. In contrast, general-purpose Large Language Models (LLMs) lack the…

机器学习 · 计算机科学 2026-02-23 Yujia Wang , Jihong Guan , Wengen Li , Shuigeng Zhou , Xuhong Wang

Large language models (LLMs) demonstrate remarkable breadth of knowledge, yet their ability to reason about computational processes remains poorly understood. Closing this gap matters for practitioners who rely on LLMs to guide algorithm…

计算与语言 · 计算机科学 2026-04-07 Sohan Venkatesh , Ashish Mahendran Kurapath , Tejas Melkote

Recent advances in large language models (LLMs) have shown impressive ability in biomedical question-answering, but have not been adequately investigated for more specific biomedical applications. This study investigates the performance of…

计算与语言 · 计算机科学 2024-03-29 Shan Chen , Yingya Li , Sheng Lu , Hoang Van , Hugo JWL Aerts , Guergana K. Savova , Danielle S. Bitterman

Large Language models (LLMs) have emerged as powerful tools for addressing challenges across diverse domains. Notably, recent studies have demonstrated that large language models significantly enhance the efficiency of biomolecular analysis…

计算与语言 · 计算机科学 2025-03-07 Jiyue Jiang , Zikang Wang , Yuheng Shan , Heyan Chai , Jiayi Li , Zixian Ma , Xinrui Zhang , Yu Li

The ability to distinguish whether an image is generated by artificial intelligence (AI) is a crucial ingredient in human intelligence, usually accompanied by a complex and dialectical forensic and reasoning process. However, current fake…

计算机视觉与模式识别 · 计算机科学 2024-09-10 Yixuan Li , Xuelin Liu , Xiaoyang Wang , Bu Sung Lee , Shiqi Wang , Anderson Rocha , Weisi Lin

Large language models (LLMs) are increasingly deployed in everyday applications, demanding robust general reasoning capabilities and diverse reasoning skillset. However, current LLM reasoning benchmarks predominantly focus on mathematical…

Task automation has been greatly empowered by the recent advances in Large Language Models (LLMs) via Python code, where the tasks ranging from software engineering development to general-purpose reasoning. While current benchmarks have…

We present MaterialFigBench, a benchmark dataset designed to evaluate the ability of multimodal large language models (LLMs) to solve university-level materials science problems that require accurate interpretation of figures. Unlike…

计算与语言 · 计算机科学 2026-03-13 Michiko Yoshitake , Yuta Suzuki , Ryo Igarashi , Yoshitaka Ushiku , Keisuke Nagato

Recent advancements in deep learning, particularly large language models (LLMs), made a significant impact on how researchers study microbiome and metagenomics data. Microbial protein and genomic sequences, like natural languages, form a…

定量方法 · 定量生物学 2024-09-18 Binghao Yan , Yunbi Nam , Lingyao Li , Rebecca A. Deek , Hongzhe Li , Siyuan Ma

The BioModels database is one of the premier databases for computational models in systems biology. The database contains over 1000 curated models and an even larger number of non-curated models. All the models are stored in the…

分子网络 · 定量生物学 2026-02-02 Bhavyahshree Navaneetha Krishnan , Adel Heydarabadipour , Herbert Sauro

Genomic language models (gLMs) hold promise for generating novel, functional DNA sequences for synthetic biology. However, realizing this potential requires models to go beyond evolutionary plausibility and understand how DNA sequence…

定量方法 · 定量生物学 2025-08-27 Shiyu Jiang , Xuyin Liu , Zitong Jerry Wang

Currently, process reward models (PRMs) have exhibited remarkable potential for test-time scaling. Since large language models (LLMs) regularly generate flawed intermediate reasoning steps when tackling a broad spectrum of reasoning and…

人工智能 · 计算机科学 2026-05-08 Zhouhao Sun , Xuan Zhang , Xiao Ding , Bibo Cai , Li Du , Kai Xiong , Xinran Dai , Fei Zhang , weidi tang , Zhiyuan Kan , Yang Zhao , Bing Qin , Ting Liu

We introduce seqBench, a parametrized benchmark for probing sequential reasoning limits in Large Language Models (LLMs) through precise, multi-dimensional control over several key complexity dimensions. seqBench allows systematic variation…

人工智能 · 计算机科学 2025-09-23 Mohammad Ramezanali , Mo Vazifeh , Paolo Santi

Recently, Large Language Models (LLM) have demonstrated impressive capability to solve a wide range of tasks. However, despite their success across various tasks, no prior work has investigated their capability in the biomedical domain yet.…

计算与语言 · 计算机科学 2024-02-21 Israt Jahan , Md Tahmid Rahman Laskar , Chun Peng , Jimmy Huang