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Clinical trials are pivotal for developing new medical treatments but typically carry risks such as patient mortality and enrollment failure that waste immense efforts spanning over a decade. Applying artificial intelligence (AI) to predict…

Clinical trial outcome prediction seeks to estimate the likelihood that a clinical trial will successfully reach its intended endpoint. This process predominantly involves the development of machine learning models that utilize a variety of…

生物大分子 · 定量生物学 2024-05-14 Chufan Gao , Tianfan Fu , Jimeng Sun

Clinical trials constitute a critical yet exceptionally challenging and costly stage of drug development (\$2.6B per drug), where protocols are encoded as complex natural language documents, motivating the use of AI systems beyond manual…

人工智能 · 计算机科学 2026-04-06 Sixue Xing , Kerui Wu , Xuanye Xia , Meng Jiang , Jintai Chen , Tianfan Fu

Although recent multi-task learning methods have shown to be effective in improving the generalization of deep neural networks, they should be used with caution for safety-critical applications, such as clinical risk prediction. This is…

机器学习 · 计算机科学 2021-02-19 A. Tuan Nguyen , Hyewon Jeong , Eunho Yang , Sung Ju Hwang

The impact of machine learning models on healthcare will depend on the degree of trust that healthcare professionals place in the predictions made by these models. In this paper, we present a method to provide people with clinical expertise…

机器学习 · 计算机科学 2021-03-05 Aniruddh Raghu , John Guttag , Katherine Young , Eugene Pomerantsev , Adrian V. Dalca , Collin M. Stultz

This research presents preliminary work to address the challenge of identifying at-risk students using supervised machine learning and three unique data categories: engagement, demographics, and performance data collected from Fall 2023…

机器学习 · 计算机科学 2025-07-16 Azucena L. Jimenez Martinez , Kanika Sood , Rakeshkumar Mahto

Predicting the performance of LLMs on individual task instances is essential to ensure their reliability in high-stakes applications. To do so, a possibility is to evaluate the considered LLM on a set of task instances and train an assessor…

计算与语言 · 计算机科学 2024-09-06 Lorenzo Pacchiardi , Lucy G. Cheke , José Hernández-Orallo

Clinical trials need to recruit a sufficient number of volunteer patients to demonstrate the statistical power of the treatment (e.g., a new drug) in curing a certain disease. Clinical trial recruitment has a significant impact on trial…

机器学习 · 计算机科学 2024-07-19 Ling Yue , Sixue Xing , Jintai Chen , Tianfan Fu

Machine learning (ML) underpins foundation models in finance, healthcare, and critical infrastructure, making them targets for data poisoning, model extraction, prompt injection, automated jailbreaking, and preference-guided black-box…

密码学与安全 · 计算机科学 2025-12-30 Armstrong Foundjem , Lionel Nganyewou Tidjon , Leuson Da Silva , Foutse Khomh

LLM based agents have recently demonstrated strong potential in automating complex tasks, yet accurately predicting startup success remains an open challenge with few benchmarks and tailored frameworks. To address these limitations, we…

人工智能 · 计算机科学 2025-04-22 Xisen Wang , Yigit Ihlamur , Fuat Alican

A major impediment to successful drug development is the complexity, cost, and scale of clinical trials. The detailed internal structure of clinical trial data can make conventional optimization difficult to achieve. Recent advances in…

Although general-purpose AI systems offer transformational opportunities in science and industry, they simultaneously raise critical concerns about safety, misuse, and potential loss of control. Despite these risks, methods for assessing…

Performance regression testing is essential in large-scale continuous-integration (CI) systems, yet executing full performance suites for every commit is prohibitively expensive. Prior work on performance regression prediction and batch…

软件工程 · 计算机科学 2026-04-02 Ali Sayedsalehi , Peter C. Rigby , Gregory Mierzwinski

We offer a pragmatic model to operationalize responsible, secure, and sustainable healthcare AI, aligning world-class technical excellence with organizational readiness. The framework includes five key pillars - Leadership & Strategy, MLOps…

计算机与社会 · 计算机科学 2025-10-21 Jimmy Joseph

Large Language Models (LLMs) are increasingly integrated into critical decision-making pipelines, a trend that raises the demand for robust and automated data analysis. Current approaches to dataset risk analysis are limited to manual…

人工智能 · 计算机科学 2026-05-28 Panteleimon Rodis

The development of artificial intelligence can be viewed as an evolution of data-driven learning paradigms, with successive shifts in data organization and utilization continuously driving advances in model capability. Current LLM research…

This work presents the development and evaluation of an NLP-enabled probabilistic classifier designed to estimate the probability of technical and regulatory success (pTRS) for clinical trials in the field of neuroscience. While…

机器学习 · 计算机科学 2025-12-02 Michael R. Doane

Early-stage startup investment is a high-risk endeavor characterized by scarce data and uncertain outcomes. Traditional machine learning approaches often require large, labeled datasets and extensive fine-tuning, yet remain opaque and…

人工智能 · 计算机科学 2025-06-05 Xianling Mu , Joseph Ternasky , Fuat Alican , Yigit Ihlamur

Deep learning models are widely used across computer vision and other domains. When working on the model induction, selecting the right architecture for a given dataset often relies on repetitive trial-and-error procedures. This procedure…

机器学习 · 计算机科学 2026-01-06 Yen-Chia Chen , Hsing-Kuo Pao , Hanjuan Huang

Anti-money laundering (AML) actions and measurements are among the priorities of financial institutions, for which machine learning (ML) has shown to have a high potential. In this paper, we propose a comprehensive and systematic approach…

人工智能 · 计算机科学 2025-09-12 Khashayar Namdar , Pin-Chien Wang , Tushar Raju , Steven Zheng , Fiona Li , Safwat Tahmin Khan
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