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Multiple Instance learning (MIL) models have been extensively used in pathology to predict biomarkers and risk-stratify patients from gigapixel-sized images. Machine learning problems in medical imaging often deal with rare diseases, making…

计算机视觉与模式识别 · 计算机科学 2023-09-12 Dinkar Juyal , Siddhant Shingi , Syed Ashar Javed , Harshith Padigela , Chintan Shah , Anand Sampat , Archit Khosla , John Abel , Amaro Taylor-Weiner

Whole slide image (WSI) analysis in digital pathology presents unique challenges due to the gigapixel resolution of WSIs and the scarcity of dense supervision signals. While Multiple Instance Learning (MIL) is a natural fit for slide-level…

计算机视觉与模式识别 · 计算机科学 2025-08-21 Sofiène Boutaj , Marin Scalbert , Pierre Marza , Florent Couzinie-Devy , Maria Vakalopoulou , Stergios Christodoulidis

Whole slide image (WSI) assessment is a challenging and crucial step in cancer diagnosis and treatment planning. WSIs require high magnifications to facilitate sub-cellular analysis. Precise annotations for patch- or even pixel-level…

计算机视觉与模式识别 · 计算机科学 2023-11-20 Simon Holdenried-Krafft , Peter Somers , Ivonne A. Montes-Majarro , Diana Silimon , Cristina Tarín , Falko Fend , Hendrik P. A. Lensch

Whole Slide Image (WSI) classification remains a challenge due to their extremely high resolution and the absence of fine-grained labels. Presently, WSI classification is usually regarded as a Multiple Instance Learning (MIL) problem when…

计算机视觉与模式识别 · 计算机科学 2023-08-24 Hongyi Wang , Luyang Luo , Fang Wang , Ruofeng Tong , Yen-Wei Chen , Hongjie Hu , Lanfen Lin , Hao Chen

Multiple Instance Learning (MIL) has garnered widespread attention in the field of Whole Slide Image (WSI) classification as it replaces pixel-level manual annotation with diagnostic reports as labels, significantly reducing labor costs.…

图像与视频处理 · 电气工程与系统科学 2025-07-08 Tianhang Nan , Hao Quan , Yong Ding , Xingyu Li , Kai Yang , Xiaoyu Cui

Whole slide images (WSIs) classification represents a fundamental challenge in computational pathology, where multiple instance learning (MIL) has emerged as the dominant paradigm. Current state-of-the-art (SOTA) MIL methods rely on…

计算机视觉与模式识别 · 计算机科学 2025-10-07 Chengying She , Chengwei Chen , Dongjie Fan , Lizhuang Liu , Chengwei Shao , Yun Bian , Ben Wang , Xinran Zhang

Digital pathology and the integration of artificial intelligence (AI) models have revolutionized histopathology, opening new opportunities. With the increasing availability of Whole Slide Images (WSIs), there's a growing demand for…

图像与视频处理 · 电气工程与系统科学 2024-04-30 Areej Alsaafin , Peyman Nejat , Abubakr Shafique , Jibran Khan , Saghir Alfasly , Ghazal Alabtah , H. R. Tizhoosh

Existing WSI analysis methods lie on the consensus that histopathological characteristics of tumors are significant guidance for cancer diagnostics. Particularly, as the evolution of cancers is a continuous process, the correlations and…

计算机视觉与模式识别 · 计算机科学 2024-07-22 Tong Shu , Jun Shi , Dongdong Sun , Zhiguo Jiang , Yushan Zheng

This paper introduces MAD-MIL, a Multi-head Attention-based Deep Multiple Instance Learning model, designed for weakly supervised Whole Slide Images (WSIs) classification in digital pathology. Inspired by the multi-head attention mechanism…

计算机视觉与模式识别 · 计算机科学 2024-04-09 Hassan Keshvarikhojasteh , Josien Pluim , Mitko Veta

Multiple instance learning (MIL) is the preferred approach for whole slide image classification. However, most MIL approaches do not exploit the interdependencies of tiles extracted from a whole slide image, which could provide valuable…

计算机视觉与模式识别 · 计算机科学 2021-08-26 Marvin Lerousseau , Maria Vakalopoulou , Eric Deutsch , Nikos Paragios

Machine learning models have become integral to many fields, but their reliability, defined as producing dependable, trustworthy, and domain-consistent predictions, remains a critical concern. Multiple Instance Learning (MIL) models…

计算机视觉与模式识别 · 计算机科学 2025-12-10 Hassan Keshvarikhojasteh , Marc Aubreville , Christof A. Bertram , Josien P. W. Pluim , Mitko Veta

Whole Slide Imaging (WSI) has become a gold standard in cancer diagnosis, inspecting multi-scale information from cellular to tissue levels. Processing an entire WSI directly is infeasible due to GPU memory constraints; thus, Multiple…

图像与视频处理 · 电气工程与系统科学 2026-05-08 Tianyi Zhang , Sicheng Chen , Borui Kang , Dankai Liao , Qiaochu Xue , Bochong Zhang , Fei Xia , Zeyu Liu , Yueming Jin

The burgeoning discipline of computational pathology shows promise in harnessing whole slide images (WSIs) to quantify morphological heterogeneity and develop objective prognostic modes for human cancers. However, progress is impeded by the…

计算机视觉与模式识别 · 计算机科学 2025-10-20 Chao Tu , Kun Huang , Jie Zhang , Qianjin Feng , Yu Zhang , Zhenyuan Ning

Traditional image-based survival prediction models rely on discriminative patch labeling which make those methods not scalable to extend to large datasets. Recent studies have shown Multiple Instance Learning (MIL) framework is useful for…

图像与视频处理 · 电气工程与系统科学 2020-09-24 Jiawen Yao , Xinliang Zhu , Jitendra Jonnagaddala , Nicholas Hawkins , Junzhou Huang

Annotating cancerous regions in whole-slide images (WSIs) of pathology samples plays a critical role in clinical diagnosis, biomedical research, and machine learning algorithms development. However, generating exhaustive and accurate…

计算机视觉与模式识别 · 计算机科学 2022-06-09 Zhenzhen Wang , Carla Saoud , Sintawat Wangsiricharoen , Aaron W. James , Aleksander S. Popel , Jeremias Sulam

Current approaches for classification of whole slide images (WSI) in digital pathology predominantly utilize a two-stage learning pipeline. The first stage identifies areas of interest (e.g. tumor tissue), while the second stage processes…

计算机视觉与模式识别 · 计算机科学 2022-07-20 Marvin Teichmann , Andre Aichert , Hanibal Bohnenberger , Philipp Ströbel , Tobias Heimann

Accurate classification of Whole Slide Images (WSIs) and Regions of Interest (ROIs) is a fundamental challenge in computational pathology. While mainstream approaches often adopt Multiple Instance Learning (MIL), they struggle to capture…

计算机视觉与模式识别 · 计算机科学 2025-08-08 Mingxi Fu , Xitong Ling , Yuxuan Chen , Jiawen Li , fanglei fu , Huaitian Yuan , Tian Guan , Yonghong He , Lianghui Zhu

Malignant lymphoma subtype classification directly impacts treatment strategies and patient outcomes, necessitating classification models that achieve both high accuracy and sufficient explainability. This study proposes a novel explainable…

计算机视觉与模式识别 · 计算机科学 2025-03-04 Daiki Nishiyama , Hiroaki Miyoshi , Noriaki Hashimoto , Koichi Ohshima , Hidekata Hontani , Ichiro Takeuchi , Jun Sakuma

Histopathology image analysis is the golden standard of clinical diagnosis for Cancers. In doctors daily routine and computer-aided diagnosis, the Whole Slide Image (WSI) of histopathology tissue is used for analysis. Because of the…

计算机视觉与模式识别 · 计算机科学 2023-11-23 Honglin Li , Yunlong Zhang , Chenglu Zhu , Jiatong Cai , Sunyi Zheng , Lin Yang

Whole slide images (WSIs) pose fundamental computational challenges due to their gigapixel resolution and the sparse distribution of informative regions. Existing approaches often treat image patches independently or reshape them in ways…

计算机视觉与模式识别 · 计算机科学 2026-05-19 Weiyi Wu , Xingjian Diao , Chunhui Zhang , Chongyang Gao , Xinwen Xu , Siting Li , Jiang Gui