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Recent advances in large language models (LLMs) have shown potential in clinical text summarization, but their ability to handle long patient trajectories with multi-modal data spread across time remains underexplored. This study…

Large language models (LLMs) have recently demonstrated their potential in clinical applications, providing valuable medical knowledge and advice. For example, a large dialog LLM like ChatGPT has successfully passed part of the US medical…

计算机视觉与模式识别 · 计算机科学 2023-02-15 Sheng Wang , Zihao Zhao , Xi Ouyang , Qian Wang , Dinggang Shen

Vision-language foundation models (VLMs) have shown great potential in feature transfer and generalization across a wide spectrum of medical-related downstream tasks. However, fine-tuning these models is resource-intensive due to their…

计算机视觉与模式识别 · 计算机科学 2025-11-18 Ye Du , Nanxi Yu , Shujun Wang

A core challenge for faithful LLM role-playing is sustaining consistent characterization throughout long, open-ended dialogues, as models frequently fail to recall and accurately apply their designated persona knowledge without explicit…

计算与语言 · 计算机科学 2026-03-23 Kai Wang , Haoyang You , Yang Zhang , Zhongjie Wang

Clinical decision-making requires reasoning over incomplete, imprecise, and linguistically expressed patient narratives. While large language models (LLMs) excel at extracting latent information from natural language, they lack the…

人工智能 · 计算机科学 2026-05-26 Xiaoyang Fan , Yufan Cai , Zhe Hou , Jin Song Dong

Analyzing whole-slide images (WSIs) requires an iterative, evidence-driven reasoning process that parallels how pathologists dynamically zoom, refocus, and self-correct while collecting the evidence. However, existing computational…

计算机视觉与模式识别 · 计算机科学 2025-11-24 Jingyun Chen , Linghan Cai , Zhikang Wang , Yi Huang , Songhan Jiang , Shenjin Huang , Hongpeng Wang , Yongbing Zhang

Sustaining long-term interactions remains a bottleneck for Large Language Models (LLMs), as their limited context windows struggle to manage dialogue histories that extend over time. Existing memory systems often treat interactions as…

计算与语言 · 计算机科学 2026-02-11 Yiming Shu , Pei Liu , Tiange Zhang , Ruiyang Gao , Jun Ma , Chen Sun

Large language models (LLMs) have emerged as effective action policies for sequential decision-making (SDM) tasks due to their extensive prior knowledge. However, this broad yet general knowledge is often insufficient for specific…

机器学习 · 计算机科学 2025-10-01 Xue Yan , Zijing Ou , Mengyue Yang , Yan Song , Haifeng Zhang , Yingzhen Li , Jun Wang

Large language model (LLM) agents face fundamental limitations in long-horizon reasoning due to finite context windows, making effective memory management critical. Existing methods typically handle long-term memory (LTM) and short-term…

计算与语言 · 计算机科学 2026-05-01 Yi Yu , Liuyi Yao , Yuexiang Xie , Qingquan Tan , Jiaqi Feng , Yaliang Li , Libing Wu

Large Language Models (LLMs) are increasingly being integrated into various medical fields, including mental health support systems. However, there is a gap in research regarding the effectiveness of LLMs in non-English mental health…

计算与语言 · 计算机科学 2026-02-10 Konstantinos Skianis , John Pavlopoulos , A. Seza Doğruöz

Protein language models (pLMs) pre-trained on vast protein sequence databases excel at various downstream tasks but often lack the structural knowledge essential for some biological applications. To address this, we introduce a method to…

We introduce PRISM (Predictive Reasoning in Sequential Medicine), a transformer-based architecture designed to model the sequential progression of clinical decision-making processes. Unlike traditional approaches that rely on isolated…

计算与语言 · 计算机科学 2025-06-16 Lionel Levine , John Santerre , Alex S. Young , T. Barry Levine , Francis Campion , Majid Sarrafzadeh

Large Language Models (LLMs) are increasingly adopted for applications in healthcare, reaching the performance of domain experts on tasks such as question answering and document summarisation. Despite their success on these tasks, it is…

计算与语言 · 计算机科学 2025-05-20 Aishik Nagar , Viktor Schlegel , Thanh-Tung Nguyen , Hao Li , Yuping Wu , Kuluhan Binici , Stefan Winkler

Brain CT report generation is significant to aid physicians in diagnosing cranial diseases. Recent studies concentrate on handling the consistency between visual and textual pathological features to improve the coherence of report. However,…

计算机视觉与模式识别 · 计算机科学 2024-10-02 Chengxin Zheng , Junzhong Ji , Yanzhao Shi , Xiaodan Zhang , Liangqiong Qu

Pathology reports are rich in clinical and pathological details but are often presented in free-text format. The unstructured nature of these reports presents a significant challenge limiting the accessibility of their content. In this…

计算与语言 · 计算机科学 2024-11-28 Ethar Alzaid , Gabriele Pergola , Harriet Evans , David Snead , Fayyaz Minhas

The applications of large language models (LLMs) in various biological domains have been explored recently, but their reasoning ability in complex biological systems, such as pathways, remains underexplored, which is crucial for predicting…

机器学习 · 计算机科学 2025-07-23 Haiteng Zhao , Chang Ma , Fangzhi Xu , Lingpeng Kong , Zhi-Hong Deng

Vision-Language Models (VLM) can support clinicians by analyzing medical images and engaging in natural language interactions to assist in diagnostic and treatment tasks. However, VLMs often exhibit "hallucinogenic" behavior, generating…

Memory is critical for enabling large language model (LLM) based agents to maintain coherent behavior over long-horizon interactions. However, existing agent memory systems suffer from two key gaps: they rely on a one-size-fits-all memory…

人工智能 · 计算机科学 2026-02-17 Mingfei Lu , Mengjia Wu , Feng Liu , Jiawei Xu , Weikai Li , Haoyang Wang , Zhengdong Hu , Ying Ding , Yizhou Sun , Jie Lu , Yi Zhang

Large language models (LLMs) have achieved strong performance on medical exam-style tasks, motivating growing interest in their deployment in real-world clinical settings. However, clinical decision-making is inherently safety-critical,…

计算与语言 · 计算机科学 2026-04-13 Xiaohan Ren , Chenxiao Fan , Wenyin Ma , Hongliang He , Chongming Gao , Xiaoyan Zhao , Fuli Feng

While current large language models (LLMs) perform well on many knowledge-related tasks, they are limited by relying on their parameters as an implicit storage mechanism. As a result, they struggle with memorizing rare events and with…

计算与语言 · 计算机科学 2025-04-18 Ali Modarressi , Abdullatif Köksal , Ayyoob Imani , Mohsen Fayyaz , Hinrich Schütze