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In positron emission tomography (PET), time-of-flight (TOF) information localizes source positions along lines of response. Cherenkov-radiator-integrated microchannel-plate photomultiplier tubes have achieved 30 ps TOF resolution,…

Aiming to measure the difference in arrival times of two coincident gamma-photons with an accuracy in the order of 200 ps, time-of-flight positron emission tomography systems commonly employ silicon photomultipliers (SiPMs) and…

医学物理 · 物理学 2021-02-11 Vanessa Nadig , David Schug , Bjoern Weissler , Volkmar Schulz

Intraoperative Gamma Probe (IPG) remains the current gold standard modality for sentinel lymph node identification and tumor removal in cancer patients. However, even alongside the optical dyes they do not meet with <5% false negative rates…

医学物理 · 物理学 2022-01-26 S. Sajedi , L. Blackberg , S. Majewski , H. Sabet

The growing interest in human-grade total body positron emission tomography (PET) systems has also application in small animal research. Due to the existing limitations in human-based studies involving drug development and novel treatment…

We describe the design, manufacture, commissioning, and performance of PMAS, the Potsdam Multi-Aperture Spectrophotometer. PMAS is a dedicated integral field spectrophotometer, optimized to cover the optical wavelength regime of 0.35--1um.…

The Imager on Board Integral Satellite (IBIS) is the imaging instrument of the INTEGRAL satellite, the hard-X/soft-gamma ray ESA mission to be launched in 2001. It provides diagnostic capabilities of fine imaging (12' FWHM), source…

天体物理学 · 物理学 2009-10-30 P. Goldoni , A. Goldwurm , P. Laurent , F. Lebrun

The Isochronous Mass Spectrometry (IMS) is a powerful tool for mass measurements of exotic nuclei with half-lives as short as several tens of micro-seconds in storage rings. In order to improve the mass resolving power while preserving the…

Current clinical PET systems utilize detectors where the scintillator typically contains single elements of 3 - 6 mm width and about 20 mm height. While providing good TOF performance, this design limits the spatial resolution and causes…

仪器与探测器 · 物理学 2022-11-17 Florian Mueller , Stephan Naunheim , Yannick Kuhl , David Schug , Torsten Solf , Volkmar Schulz

The purpose of this study was to show how advanced concepts of compact, lossless and "Time Of Flight" (TOF) capable electronics similar to those foreseen for the LHC and ILC experiments could be fairly and easily transferred to the medical…

仪器与探测器 · 物理学 2009-08-03 P. -E. Vert , J. Lecoq , G. Montarou , N. Pauna , B. Joly , M. Boutemeur , H. Mathez , R. Gaglione , P. Le Dû

The TT-PET collaboration is developing a small animal TOF-PET scanner based on silicon detectors featuring 30 ps RMS time resolution and intended to be inserted in an existing MRI scanner. The TT-PET scanner makes use of a stack of layers…

We present simulations of whole-body low-dose time-of-flight positron emission tomography (TOF-PET) based on the direct surface production [1] by 511 keV gamma rays of energetic electrons via the Photo-electric and Compton Effects,…

The TT-PET collaboration is developing a small animal TOF-PET scanner based on monolithic silicon pixel sensors in SiGe BiCMOS technology. The demonstrator chip, a small-scale version of the final detector ASIC, consists of a 3 x 10 pixel…

Positron Emission Tomography (PET) enables functional imaging of deep brain structures, but the bulk and weight of current systems preclude their use during many natural human activities, such as locomotion. The proposed long-term solution…

机器人学 · 计算机科学 2023-12-07 Junxiang Wang , Ti Wu , Iulian I. Iordachita , Peter Kazanzides

Recently, we reported an ion trap experiment with an integrated time-of-flight mass spectrometer (TOFMS) [Phys. Rev. Appl. 2, 034013 (2014)] focussing on the improvement of mass resolution and detection limit due to sample preparation at…

原子物理 · 物理学 2016-01-20 Christian Schneider , Steven J. Schowalter , Peter Yu , Eric R. Hudson

A high momentum resolution is required for the precision measurement of Higgs boson at the International Linear Collider (ILC) using the recoil mass technique. The International Large Detector (ILD) is designed to meet this requirement by…

仪器与探测器 · 物理学 2020-02-28 Yumi Aoki

Objective: This paper introduces a novel PET imaging methodology called 3-dimensional positron imaging (3D{\pi}), which integrates total-body (TB) coverage, time-of-flight (TOF) technology, ultra-low dose imaging capabilities, and…

In this paper we prove that the choice of a suitable treatment of the scintillator surfaces, along with suitable photodetectors electronics and specific algorithms for raw data analysis, allow to achieve an optimal tradeoff between energy,…

医学物理 · 物理学 2012-03-02 Luigi Cosentino , Paolo Finocchiaro , Alfio Pappalardo , Franco Garibaldi

Positron Emission Tomography (PET) is an important molecular imaging tool widely used in medicine. Traditional PET systems rely on complete detector rings for full angular coverage and reliable data collection. However, incomplete-ring PET…

计算机视觉与模式识别 · 计算机科学 2026-05-26 Yeqi Fang , Rong Zhou

Prostate cancer is the most common disease in men and the second leading cause of death from cancer. Generic large imaging instruments used in cancer diagnosis have sensitivity, spatial resolution, and contrast inadequate for the task of…

Positron emission tomography (PET) is a medical imaging method based on the measurement of concentrations of positron-emitting radionuclides in a living body. In the PET imaging system, glucose is labeled with a positron-emitting…

信号处理 · 电气工程与系统科学 2022-09-27 Mehmet Akif Ozdemir , Ali Tangel
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