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Background: The concept of combinatorial biomarkers was conceived around 2010: it was noticed that simple biomarkers are often inadequate for recognizing and characterizing complex diseases. Methods: Here we present an algorithmic search…

神经元与认知 · 定量生物学 2013-12-09 Balazs Szalkai , Vince K. Grolmusz , Vince I. Grolmusz , Coalition Against Major Diseases

Alzheimer's disease (AD) leads to progressive cognitive decline, making early detection crucial for effective intervention. While deep learning models have shown high accuracy in AD diagnosis, their lack of interpretability limits clinical…

计算机视觉与模式识别 · 计算机科学 2025-06-17 Yasmine Mustafa , Mohamed Elmahallawy , Tie Luo

X-ray scattering measurements of in situ human brain tissue encode structural signatures of pathological cross-$\beta$ inclusions, yet systematic exploitation of these data for automated detection remains challenging due to substrate…

图像与视频处理 · 电气工程与系统科学 2025-11-18 Abdullah Al Bashit , Prakash Nepal , Lee Makowski

Melanoma is one of the most aggressive and deadliest skin cancers, leading to mortality if not detected and treated in the early stages. Artificial intelligence techniques have recently been developed to help dermatologists in the early…

机器学习 · 计算机科学 2026-02-19 Wadduwage Shanika Perera , ABM Islam , Van Vung Pham , Min Kyung An

Dementia is a complex syndrome impacting cognitive and emotional functions, with Alzheimer's disease being the most common form. This study focuses on enhancing dementia prediction using machine learning (ML) techniques on patient health…

人工智能 · 计算机科学 2026-01-13 Shafiul Ajam Opee , Nafiz Fahad , Anik Sen , Rasel Ahmed , Fariha Jahan , Md. Kishor Morol , Md Rashedul Islam

With the advances in computationally efficient artificial Intelligence (AI) techniques and their numerous applications in our everyday life, there is a pressing need to understand the computational details hidden in black box AI techniques…

机器学习 · 计算机科学 2023-11-13 Mrutyunjaya Panda , Soumya Ranjan Mahanta

The detection of Alzheimers disease (AD) is considered crucial, as timely intervention can improve patient outcomes. Electroencephalogram (EEG)-based diagnosis has been recognized as a non-invasive, accessible, and cost-effective approach…

Diabetes is a serious worldwide health issue, and successful intervention depends on early detection. However, overlapping risk factors and data asymmetry make prediction difficult. To use extensive health survey data to create a machine…

According to the American Diabetes Association(ADA), 30.3 million people in the United States have diabetes, but only 7.2 million may be undiagnosed and unaware of their condition. Type 2 diabetes is usually diagnosed for most patients…

机器学习 · 计算机科学 2019-10-22 Ramya Akula , Ni Nguyen , Ivan Garibay

Multi-modal biological, imaging, and neuropsychological markers have demonstrated promising performance for distinguishing Alzheimer's disease (AD) patients from cognitively normal elders. However, it remains difficult to early predict when…

计算机视觉与模式识别 · 计算机科学 2019-01-08 Hongming Li , Yong Fan

Alzheimer's disease is a progressive, neurodegenerative disorder that causes memory loss and cognitive decline. While there has been extensive research in applying deep learning models to Alzheimer's prediction tasks, these models remain…

计算机视觉与模式识别 · 计算机科学 2025-09-15 Emily Kaczmarek , Justin Szeto , Brennan Nichyporuk , Tal Arbel

Alzheimer's disease (AD) presents a complex, multifaceted challenge to patients, caregivers, and the healthcare system, necessitating integrated and dynamic support solutions. While artificial intelligence (AI) offers promising avenues for…

多智能体系统 · 计算机科学 2025-10-13 Adib Bazgir , Amir Habibdoust , Xing Song , Yuwen Zhang

In visual object classification, humans often justify their choices by comparing objects to prototypical examples within that class. We may therefore increase the interpretability of deep learning models by imbuing them with a similar style…

计算机视觉与模式识别 · 计算机科学 2023-10-26 Ayodeji Ijishakin , Ahmed Abdulaal , Adamos Hadjivasiliou , Sophie Martin , James Cole

Alzheimer's disease (AD) is the most prevalent neurodegenerative disease; yet its currently available treatments are limited to stopping disease progression. Moreover, effectiveness of these treatments is not guaranteed due to the…

机器学习 · 计算机科学 2024-02-02 Diego Machado Reyes , Hanqing Chao , Juergen Hahn , Li Shen , Pingkun Yan

Cognitive impairment detection through spontaneous speech is a promising avenue for early diagnosis of Alzheimer's disease (AD) and mild cognitive impairment (MCI), where timely intervention can significantly improve patient outcomes. The…

声音 · 计算机科学 2025-02-19 Yifan Gao , Long Guo , Hong Liu

The automatic early diagnosis of prodromal stages of Alzheimer's disease is of great relevance for patient treatment to improve quality of life. We address this problem as a multi-modal classification task. Multi-modal data provides richer…

Early and accurate diagnosis of Alzheimer's disease (AD) and its prodromal period mild cognitive impairment (MCI) is essential for the delayed disease progression and the improved quality of patients'life. The emerging computer-aided…

图像与视频处理 · 电气工程与系统科学 2021-07-29 Fan Zhang , Bo Pan , Pengfei Shao , Peng Liu , Shuwei Shen , Peng Yao , Ronald X. Xu

Mental disorders are among the leading causes of disability worldwide. The first step in treating these conditions is to obtain an accurate diagnosis, but the absence of established clinical tests makes this task challenging. Machine…

信号处理 · 电气工程与系统科学 2021-10-13 Caroline L. Alves , Aruane M. Pineda , Kirstin Roster , Christiane Thielemann , Francisco A. Rodrigues

The event-based model (EBM) for data-driven disease progression modeling estimates the sequence in which biomarkers for a disease become abnormal. This helps in understanding the dynamics of disease progression and facilitates early…

计算机视觉与模式识别 · 计算机科学 2017-02-22 Vikram Venkatraghavan , Esther Bron , Wiro Niessen , Stefan Klein

Collecting and accessing a large amount of medical data is very time-consuming and laborious, not only because it is difficult to find specific patients but also because it is required to resolve the confidentiality of a patient's medical…

声音 · 计算机科学 2021-03-04 Junghyun Koo , Jie Hwan Lee , Jaewoo Pyo , Yujin Jo , Kyogu Lee
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