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Scientific research demands sophisticated reasoning over multimodal data, a challenge especially prevalent in biology. Despite recent advances in multimodal large language models (MLLMs) for AI-assisted research, existing multimodal…

Recent advancements in Multimodal Large Language Models (MLLMs) have demonstrated significant potential in recommendation systems. However, the effective application of MLLMs to multimodal sequential recommendation remains unexplored: A)…

信息检索 · 计算机科学 2025-12-25 Haoyu Wang , Yitong Wang , Jining Wang

Multimodal large language models (MLLMs) hold considerable promise for applications in healthcare. However, their deployment in safety-critical settings is hindered by two key limitations: (i) sensitivity to prompt design, and (ii) a…

计算机视觉与模式识别 · 计算机科学 2025-10-14 Anita Kriz , Elizabeth Laura Janes , Xing Shen , Tal Arbel

Recent advances in Protein Language Models (PLMs) have transformed protein engineering, yet unlike their counterparts in Natural Language Processing (NLP), current PLMs exhibit a fundamental limitation: they excel in either Protein Language…

计算工程、金融与科学 · 计算机科学 2025-09-16 Liuzhenghao Lv , Zongying Lin , Hao Li , Yuyang Liu , Jiaxi Cui , Calvin Yu-Chian Chen , Li Yuan , Yonghong Tian

Reinforcement Learning (RL) has shown remarkable success in enhancing the reasoning capabilities of Large Language Models (LLMs). Process-Supervised RL (PSRL) has emerged as a more effective paradigm compared to outcome-based RL. However,…

In contrast to their remarkable performance on general knowledge QA, the true abilities of Large Language Models (LLMs) in tasks demanding deep, specialized reasoning, such as in protein biology, have yet to be thoroughly investigated.…

定量方法 · 定量生物学 2025-12-30 Dingyi Rong , Zijian Chen , Qi Jia , Kaiwei Zhang , Haotian Lu , Guangtao Zhai , Ning Liu

Protein language models (PLMs) have demonstrated remarkable capabilities in learning relationships between protein sequences and functions. However, finetuning these large models requires substantial computational resources, often with…

机器学习 · 计算机科学 2025-12-09 Shuo Zhang , Jian K. Liu

The global demand for sustainable protein sources has accelerated the need for intelligent tools that can rapidly process and synthesise domain-specific scientific knowledge. In this study, we present a proof-of-concept multi-agent…

人工智能 · 计算机科学 2025-06-26 Alexander D. Kalian , Jaewook Lee , Stefan P. Johannesson , Lennart Otte , Christer Hogstrand , Miao Guo

Multimodal Large Language Models (MLLMs) in real-world applications require access to external knowledge sources and must remain responsive to the dynamic and ever-changing real-world information in order to address information-seeking and…

计算机视觉与模式识别 · 计算机科学 2025-10-15 Kartik Narayan , Yang Xu , Tian Cao , Kavya Nerella , Vishal M. Patel , Navid Shiee , Peter Grasch , Chao Jia , Yinfei Yang , Zhe Gan

Pre-trained LLMs have demonstrated substantial capabilities across a range of conventional natural language processing (NLP) tasks, such as summarization and entity recognition. In this paper, we explore the application of LLMs in the…

定量方法 · 定量生物学 2024-08-14 Kamyar Zeinalipour , Neda Jamshidi , Monica Bianchini , Marco Maggini , Marco Gori

Large Language Models (LLMs) excel at reasoning and generation but are inherently limited by static pretraining data, resulting in factual inaccuracies and weak adaptability to new information. Retrieval-Augmented Generation (RAG) addresses…

计算与语言 · 计算机科学 2025-11-03 Qi Luo , Xiaonan Li , Yuxin Wang , Tingshuo Fan , Yuan Li , Xinchi Chen , Xipeng Qiu

Recent advances in multimodal large language models (MLLMs) have substantially expanded the capabilities of multimodal retrieval, enabling systems to align and retrieve information across visual and textual modalities. Yet, existing…

计算机视觉与模式识别 · 计算机科学 2026-03-03 Xuan Lu , Kangle Li , Haohang Huang , Rui Meng , Wenjun Zeng , Xiaoyu Shen

Recent advances in Reinforcement Learning with Verifiable Rewards (RLVR) for multimodal large language models (MLLMs) have mainly focused on improving final answer correctness and strengthening visual grounding. However, a critical…

计算机视觉与模式识别 · 计算机科学 2026-03-30 Jinda Lu , Junkang Wu , Jinghan Li , Kexin Huang , Shuo Yang , Mingzhu Chen , Jiancan Wu , Kuien Liu , Xiang Wang

Long chain-of-thought (CoT) significantly enhances the reasoning capabilities of large language models (LLMs). However, extensive reasoning traces lead to inefficiencies and increased time-to-first-token (TTFT). We propose a training…

计算与语言 · 计算机科学 2026-01-08 Roy Xie , David Qiu , Deepak Gopinath , Dong Lin , Yanchao Sun , Chong Wang , Saloni Potdar , Bhuwan Dhingra

Large Language Model (LLM) based listwise ranking has shown superior performance in many passage ranking tasks. With the development of Large Reasoning Models (LRMs), many studies have demonstrated that step-by-step reasoning during…

信息检索 · 计算机科学 2026-04-23 Wenhan Liu , Xinyu Ma , Weiwei Sun , Yutao Zhu , Yuchen Li , Dawei Yin , Zhicheng Dou

Large language models (LLMs), especially Explicit Long Chain-of-Thought (CoT) reasoning models like DeepSeek-R1 and QWQ, have demonstrated powerful reasoning capabilities, achieving impressive performance in commonsense reasoning and…

计算与语言 · 计算机科学 2025-08-13 Jiatong Li , Weida Wang , Qinggang Zhang , Junxian Li , Di Zhang , Changmeng Zheng , Shufei Zhang , Xiaoyong Wei , Qing Li

Recent advances in medical large language models have explored Test-Time Reinforcement Learning (TTRL) to enhance reasoning. However, standard TTRL often relies on majority voting (MV) as a heuristic supervision signal, which can be…

机器学习 · 计算机科学 2026-03-11 Kailong Fan , Anqi Pu , Yichen Wu , Wanhua Li , Yicong Li , Hanspeter Pfister , Huafeng Liu , Xiang Li , Quanzheng Li , Ning Guo

Recent advances in large language models have demonstrated considerable potential in scientific domains such as drug repositioning. However, their effectiveness remains constrained when reasoning extends beyond the knowledge acquired during…

人工智能 · 计算机科学 2025-08-01 Zerui Yang , Yuwei Wan , Siyu Yan , Yudai Matsuda , Tong Xie , Bram Hoex , Linqi Song

Multimodal information retrieval (MMIR) has gained attention for its flexibility in handling text, images, or mixed queries and candidates. Recent breakthroughs in multimodal large language models (MLLMs) boost MMIR performance by…

信息检索 · 计算机科学 2026-02-27 Dawei Su , Dongsheng Wang

Reinforcement learning (RL) enhanced large language models (LLMs), particularly exemplified by DeepSeek-R1, have exhibited outstanding performance. Despite the effectiveness in improving LLM capabilities, its implementation remains highly…

计算与语言 · 计算机科学 2025-02-25 Shuhe Wang , Shengyu Zhang , Jie Zhang , Runyi Hu , Xiaoya Li , Tianwei Zhang , Jiwei Li , Fei Wu , Guoyin Wang , Eduard Hovy