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Alzheimer's disease is characterised by the spreading of misfolded proteins and progressive structural changes in the brain. Despite significant clinical research, understanding how microscopic protein dynamics translate into macroscopic…

计算工程、金融与科学 · 计算机科学 2026-03-23 A. Vazquez-Palomo , C. Betegón , J. Weickenmeier , E. Martínez-Pañeda

The development of biophysical models for clinical applications is rapidly advancing in the research community, thanks to their predictive nature and their ability to assist the interpretation of clinical data. However, high-resolution and…

This paper proposes a novel optimization framework for discrete phase shifts of a reconfigurable intelligent surface (RIS) using a coherent Ising machine (CIM). Unlike conventional methods based on iterative convex approximation or…

Accurate extraction and segmentation of the cerebral arteries from digital subtraction angiography (DSA) sequences is essential for developing reliable clinical management models of complex cerebrovascular diseases. Conventional loss…

计算机视觉与模式识别 · 计算机科学 2025-11-26 Muhammad Irfan , Nasir Rahim , Khalid Mahmood Malik

Alzheimer's disease (AD) is a complex neurodegenerative disorder characterized by the progressive accumulation of misfolded proteins, leading to cognitive decline. This study presents a novel stochastic modelling approach to simulate the…

神经元与认知 · 定量生物学 2024-11-06 Alec MacIver , Hina Shaheen

Stroke is the second leading cause of mortality worldwide. Immediate attention and diagnosis play a crucial role regarding patient prognosis. The key to diagnosis consists in localizing and delineating brain lesions. Standard stroke…

图像与视频处理 · 电气工程与系统科学 2024-09-05 Santiago Gómez , Daniel Mantilla , Gustavo Garzón , Edgar Rangel , Andrés Ortiz , Franklin Sierra-Jerez , Fabio Martínez

Alzheimer's disease (AD) is a complex neurodegenerative disorder characterized by the accumulation of amyloid-beta (A$\beta$) and phosphorylated tau (p-tau) proteins, leading to cognitive decline measured by the Alzheimer's Disease…

神经元与认知 · 定量生物学 2025-04-21 Swadesh Pal , Roderick Melnik

This letter introduces a novel partitioning scheme for reconfigurable intelligent surfaces (RISs) that simultaneously consider RIS identification and beamforming. The proposed scheme dynamicly and efficiently allocates RIS elements between…

信号处理 · 电气工程与系统科学 2025-11-17 Yarkın Gevez , Aymen Khaleel , Ertugrul Basar

Positron emission tomography (PET) is a well-established functional imaging technique for diagnosing brain disorders. However, PET's high costs and radiation exposure limit its widespread use. In contrast, magnetic resonance imaging (MRI)…

图像与视频处理 · 电气工程与系统科学 2024-10-24 Yitong Li , Igor Yakushev , Dennis M. Hedderich , Christian Wachinger

Deep learning methods have significantly advanced medical image segmentation, yet their success hinges on large volumes of manually annotated data, which require specialized expertise for accurate labeling. Additionally, these methods often…

图像与视频处理 · 电气工程与系统科学 2024-09-04 Wangang Cheng , Guanghua He , Keli Hu , Mingyu Fang , Liang Dong , Zhong Li , Hancan Zhu

Virtual staining has emerged as a powerful alternative to traditional histopathological staining techniques, enabling rapid, reagent-free image transformations. However, existing evaluation methods predominantly rely on full-reference image…

图像与视频处理 · 电气工程与系统科学 2025-07-18 Qiankai Wang , James E. D. Tweel , Parsin Haji Reza , Anita Layton

Physics-Informed Neural Network (PINN) is a novel multi-task learning framework useful for solving physical problems modeled using differential equations (DEs) by integrating the knowledge of physics and known constraints into the…

机器学习 · 计算机科学 2024-09-18 Shivprasad Kathane , Shyamprasad Karagadde

This work introduces Physics-informed State-space neural network Models (PSMs), a novel solution to achieving real-time optimization, flexibility, and fault tolerance in autonomous systems, particularly in transport-dominated systems such…

机器学习 · 计算机科学 2024-08-21 Akshay J. Dave , Richard B. Vilim

A physics informed neural network (PINN) incorporates the physics of a system by satisfying its boundary value problem through a neural network's loss function. The PINN approach has shown great success in approximating the map between the…

数值分析 · 数学 2022-03-17 Revanth Mattey , Susanta Ghosh

Auto-regressive partial differential equation (PDE) foundation models have shown great potential in handling time-dependent data. However, these models suffer from the shortcut problem deeply rooted in auto-regressive prediction, causing…

机器学习 · 计算机科学 2025-06-03 Congcong Zhu , Xiaoyan Xu , Jiayue Han , Jingrun Chen

Enzymes and proteins are live driven biochemicals, which has a dramatic impact over the environment, in which it is active. So, therefore, it is highly looked-for to build such a robust and highly accurate automatic and computational model…

生物大分子 · 定量生物学 2021-01-11 Zaheer Ullah Khan , Dechang Pi , Izhar Ahmed Khan , Asif Nawaz , Jamil Ahmad , Mushtaq Hussain

Many of the concepts which are at the basis of the development associated with a quantitative treatment of the variety of phenomena associated with the spontaneous breaking of gauge symmetry in nuclei have been instrumental in connection…

核理论 · 物理学 2017-08-23 R. A. Broglia

Accurate time-series forecasting for complex physical systems is the backbone of modern industrial monitoring and control, yet deep learning models often lack the physical consistency required in regulated environments.To bridge this gap,…

机器学习 · 计算机科学 2026-05-18 Ramona Rubini , Siavash Khodakarami , Aniruddha Bora , George Em Karniadakis , Michele Dassisti

Accurate forecasting of contagious diseases is critical for public health policymaking and pandemic preparedness. We propose a new infectious disease forecasting model based on physics-informed neural networks (PINNs), an emerging…

Despite the recognized importance of the multi-scale spatio-temporal organization of proteins, most computational tools can only access a limited spectrum of time and spatial scales, thereby ignoring the effects on protein behavior of the…

生物大分子 · 定量生物学 2011-09-21 Antoine Delmotte , Edward W Tate , Sophia N Yaliraki , Mauricio Barahona
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