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Despite the progress in deep learning networks, efficient learning at the edge (enabling adaptable, low-complexity machine learning solutions) remains a critical need for defense and commercial applications. We envision a pipeline to…

We demonstrate the first-ever nontrivial, biologically realistic connectome simulated on neuromorphic computing hardware. Specifically, we implement the whole-brain connectome of the adult Drosophila melanogaster (fruit fly) from the…

分布式、并行与集群计算 · 计算机科学 2025-08-26 Felix Wang , Bradley H. Theilman , Fred Rothganger , William Severa , Craig M. Vineyard , James B. Aimone

The brain's functional connectivity fluctuates over time instead of remaining steady in a stationary mode even during the resting state. This fluctuation establishes the dynamical functional connectivity that transitions in a non-random…

神经元与认知 · 定量生物学 2022-03-28 Shikuang Deng , Jingwei Li , B. T. Thomas Yeo , Shi Gu

Connectome-constrained neural networks are often evaluated against sparse random controls and then interpreted as evidence that biological graph topology improves learning efficiency. We revisit that claim in a controlled flyvis-based study…

神经元与认知 · 定量生物学 2026-04-07 Nalin Dhiman

Graph Transformers have recently been successful in various graph representation learning tasks, providing a number of advantages over message-passing Graph Neural Networks. Utilizing Graph Transformers for learning the representation of…

神经元与认知 · 定量生物学 2023-12-27 Byung-Hoon Kim , Jungwon Choi , EungGu Yun , Kyungsang Kim , Xiang Li , Juho Lee

What can we learn from a connectome? We constructed a simplified model of the first two stages of the fly visual system, the lamina and medulla. The resulting hexagonal lattice convolutional network was trained using backpropagation through…

神经元与认知 · 定量生物学 2018-06-26 Fabian David Tschopp , Michael B. Reiser , Srinivas C. Turaga

We propose a data-driven approach to represent neuronal network dynamics as a Probabilistic Graphical Model (PGM). Our approach learns the PGM structure by employing dimension reduction to network response dynamics evoked by stimuli applied…

神经元与认知 · 定量生物学 2017-11-02 Hexuan Liu , Jimin Kim , Eli Shlizerman

The brain's intricate connectome, a blueprint for its function, presents immense complexity, yet it arises from a compact genetic code, hinting at underlying low-dimensional organizational principles. This work bridges connectomics and…

人工智能 · 计算机科学 2025-05-28 Yubin Li , Xingyu Liu , Guozhang Chen

The complete connectome of the Drosophila larva brain offers a unique opportunity to investigate whether biologically evolved circuits can support artificial intelligence. We convert this wiring diagram into a Biological Processing Unit…

神经与进化计算 · 计算机科学 2025-07-16 Siyu Yu , Zihan Qin , Tingshan Liu , Beiya Xu , R. Jacob Vogelstein , Jason Brown , Joshua T. Vogelstein

The study of dynamic functional connectomes has provided valuable insights into how patterns of brain activity change over time. Neural networks process information through artificial neurons, conceptually inspired by patterns of activation…

神经元与认知 · 定量生物学 2025-08-12 Yutong Wu , Peilin He , Tananun Songdechakraiwut

Functional connectivity (FC) between regions of the brain can be assessed by the degree of temporal correlation measured with functional neuroimaging modalities. Based on the fact that these connectivities build a network, graph-based…

计算机视觉与模式识别 · 计算机科学 2021-10-22 Byung-Hoon Kim , Jong Chul Ye , Jae-Jin Kim

Graph deep learning models, a class of AI-driven approaches employing a message aggregation mechanism, have gained popularity for analyzing the functional brain connectome in neuroimaging. However, their actual effectiveness remains…

神经与进化计算 · 计算机科学 2026-02-10 Keqi Han , Yao Su , Lifang He , Liang Zhan , Sergey Plis , Vince Calhoun , Carl Yang

Brain networks characterize complex connectivities among brain regions as graph structures, which provide a powerful means to study brain connectomes. In recent years, graph neural networks have emerged as a prevalent paradigm of learning…

机器学习 · 计算机科学 2022-06-10 Yi Yang , Yanqiao Zhu , Hejie Cui , Xuan Kan , Lifang He , Ying Guo , Carl Yang

The connectome, a map of the structural and/or functional connections in the brain, provides a complex representation of the neurobiological phenotypes on which it supervenes. This information-rich data modality has the potential to…

Recent advances in neuroimaging along with algorithmic innovations in statistical learning from network data offer a unique pathway to integrate brain structure and function, and thus facilitate revealing some of the brain's organizing…

信号处理 · 电气工程与系统科学 2021-12-21 Yang Li , Gonzalo Mateos , Zhengwu Zhang

Accurately predicting individual neurons' responses and spatial functional properties in complex visual tasks remains a key challenge in understanding neural computation. Existing whole-brain connectome models of Drosophila often rely on…

神经元与认知 · 定量生物学 2025-12-09 Jiangping Xie , Ruohan Ren , Xiao Zhou , Ao Zheng , Jiasong Zhu , Wenyu Jiang , Ziran Zhao

Decrypting intelligence from the human brain construct is vital in the detection of particular neurological disorders. Recently, functional brain connectomes have been used successfully to predict behavioral scores. However,…

神经元与认知 · 定量生物学 2022-09-28 Imen Jegham , Islem Rekik

Volumetric brain reconstructions provide an unprecedented opportunity to gain insights into the complex connectivity patterns of neurons in an increasing number of organisms. Here, we model and quantify the complexity of the resulting…

神经元与认知 · 定量生物学 2024-05-13 Anastasiya Salova , István A. Kovács

The human brain is highly adaptive: its functional connectivity reconfigures on multiple timescales during cognition and learning, enabling flexible information processing. By contrast, artificial neural networks typically rely on…

神经与进化计算 · 计算机科学 2025-10-29 Peilin He , Tananun Songdechakraiwut

We aimed to explore the capability of deep learning to approximate the function instantiated by biological neural circuits-the functional connectome. Using deep neural networks, we performed supervised learning with firing rate observations…

神经元与认知 · 定量生物学 2022-11-24 Sihao Liu , Augustine N Mavor-Parker , Caswell Barry
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